Journals / Türk Otolarengoloji Arşivi / 2014 / Cilt: 52 - Sayı: 4

Vertebrobaziler yetmezlik tespit edilen hastalarda işitme eşikleri ve serum apelin düzeyleri

Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency

Pages
126–130
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Tis result wasthought to be due to the absence of severe hemodynamicabnormalities and atherosclerosis in the study groups.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Vertebrobasilar insufciency (VBI) is a clini- cal entity that results from the decrease in fow volumesdue to hemodynamic changes in the vertebral artery andits branches.
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Key Findings & Data:Pure toneaudiometer tests between 2500-8000 Hertz (Hz) wereapplied, and plasma levels of apelin, routine biochem- istry parameters, and levels of C-reactive protein werestudied in these patients.
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Conclusion & Impact:Tis result wasthought to be due to the absence of severe hemodynamicabnormalities and atherosclerosis in the study groups.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Vertebrobasilar insufciency (VBI) is a clini- cal entity that results from the decrease in fow volumesdue to hemodynamic changes in the vertebral artery andits branches. Herein, we aimed to investigate the hearingthresholds and serum apelin levels in VBI patients whowere admitted to our clinics with vertigo. Methods: Patients who were admitted to our clinicswith vertigo were included in our study. Tey underwentbilateral carotid and vertebral artery color Doppler ul- trason investigation to determine VBI. Ten, they weregrouped into two groups: having VBI or not. Pure toneaudiometer tests between 2500-8000 Hertz (Hz) wereapplied, and plasma levels of apelin, routine biochem- istry parameters, and levels of C-reactive protein werestudied in these patients. Results: Tirty-eight (47% women, mean age 57.6±9.3)patients with VBI and 24 controls (50% women, mean age 57.0±10.1) were included. In patients with VBI,hearing thresholds were higher in the left ear exceptat the 500 Hz frequency. Serum apelin levels were notstatistically diferent between the 2 groups.Conclusion: In this study, several abnormalities inhearing tests were determined in VBI patients. Tehypothesis was that basilar artery dysfunction causedby asymmetry of vertebral artery fow volumes in VBImight increase apelin levels, which have functions in an-giogenesis, hemostasis, and cardiovascular hemodynam-ics. However, we could not fnd a signifcant diferencein apelin levels between the 2 groups. Tis result wasthought to be due to the absence of severe hemodynamicabnormalities and atherosclerosis in the study groups.

Özet

Amaç: Vertebrobaziler yetmezlik (VBY) vertebral arterve dallarında oluşan hemodinamik değişiklikler sonu- cunda akım hacminin azalması ile oluşan klinik tablo- dur. Bu çalışmanın amacı baş dönmesi şikayeti ile baş- vuran ve VBY saptanan hastaların işitme eşiklerinin veserum apelin değerlerinin belirlenmesidir. Yöntemler: Çalışmaya baş dönmesi şikayeti ile başvuranhastalar dahil edildi. Bilateral karotis ve vertebral arter- lerin renkli Doppler ultrason incelemeleri yapıldı. Has- talar VBY tanısı alan ve almayan olarak 2 gruba ayrıldı.Çalışmaya alınan kişilere 250-8000 Hertz (Hz) frekans- lar arasında saf ses odyometrisi, apelin, rutin biyokimyaparametreleri, tam kan sayımı ve C-reaktif protein öl- çümleri yapıldı. Bulgular: Çalışmaya VBY tespit edilen 38 (%47 kadın;yaş ortalaması: 57.6±9.3) hasta ve VBY tespit edilme- yen 24 (%50 kadın; yaş ortalaması: 57.0±10.1) hastaalındı. VBY olan grupta işitme eşiklerinin sadece solkulakta 500 Hz frekansı hariç diğer tüm frekanslarda yükseldiği görüldü. Ancak iki grup arasında apelin dü-zeyleri bakımından istatiksel olarak anlamlı farklılıktespit edilmedi.Sonuç: Bu çalışmada VBY olan hastalarda işitme tes-tinde saptanan anormallikler belirlenmiştir. Angiogene-zis, sıvı hemostazı ve kardiyovasküler hemodinamininsağlanmasında görev aldığı gösterilen apelin değerinin;VBYde vertebral arterlerdeki akım volümlerindeki asi-metrinin bu baziller arter disfonksiyonu yaratabileceğihipotezinden yola çıkılarak VBYde yükselebileceği dü-şünülmüştü. Bununla birlikte her iki grup apelin seviye-leri arasında anlamlı bir fark bulunamamıştır. Bu durumise çalışmaya dahil edilen hastalarda ciddi düzeyde he-modinami bozukluğu ve ateroskleroz olmaması ile iliş-kilendirilmiştir.

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Cite This Article

ATAÇ, G. K., ÇANDAR, T., DEMİRTAŞ, S., ÖZDEMİR, S., EZERARSLAN, H., KOCATÜRK, S. (2022). Vertebrobaziler yetmezlik tespit edilen hastalarda işitme eşikleri ve serum apelin düzeyleri. Türk Otolarengoloji Arşivi, Cilt: 52 - Sayı: 4, 126–130. https://ajindex.com/articles/639924

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References (14)

  1. Nakagawa T, Yamane H, Nakai Y, Shigeta T, Takashima T. Evalua- tion of the vertebrobasilar arterial system by magnetic resonance an- giography in the diagnosis of the vertebrobasilar insuficiency. Acta Otolaryngol 1998
  2. [CrossRef] 2. Liu Y, Song CY, Wu SS, Liang QH, Yuan LQ, Liao EY. Novel adipokines and bone metabolism. Int J Endocrinol 2013
  3. 895045. [CrossRef] 3. Wozniak S, Gee L, Wachtel M, Frezza E. Adipose Tissue: Te New Endocrin Organ A Review Article. Digestive Diseases and Sciences 2009
  4. [CrossRef] 4. Kleinz MJ, Davenport AP. Emerging roles of apelin in biology and medicine Pharmacology & Terapeutics 2005
  5. [CrossRef] 5. Lee DK, George, S.R., O’Dowd, B.F. Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity. Trends Pharmacol Sci 2006
  6. [CrossRef] 6. Bendick PJ, Glover JL. Hemodynamic evaluation of vertebral arteries by duplex ultrasound. Surg Clin North Am 1990
  7. Wardlaw JM, Chappell FM, Best JJ, Wartolowska K, Berry E
  8. NHS Research and Development Health Technology Assessment Caro- tid Stenosis Imaging Group. Noninvasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis. Lancet 2006
  9. [CrossRef] 8. Hong JM, Chung CS, Bang OY, Yong SW, Joo IS, Huh K. Verteb- ral artery dominance contributes to basilar artery curvature and pe- ri-vertebrobasilar junctional infarcts. J Neurol Neurosurg Psychiatry 2009
  10. [CrossRef] 9. Bartels E, Knauth M, Liebetanz D, Paulus W. Traumatic dissection of the vertebral artery: value of sonographic diagnostics. Cerebro- vasc Dis 2006
  11. [CrossRef] 10. Society of Atherosclerosis Imaging and Prevention Developed in collaboration with the International Atherosclerosis Society. App- ropriate use criteria for carotid intima media thickness testing. At- herosclerosis 2011
  12. [CrossRef] 11. Pirodda A, Ferri GG, Modugno GC, Borghi C. Systemic Hypoten- sion and the Development of Acute Sensorineural Hearing Loss in Young Healthy Subjects. Arch Otolaryngol Head Neck Surg 2001
  13. [CrossRef] 12. Suckfull M, Zacharias S, Mees K. Exploratory analysis of risk factors of acute inner ear dysfunction. Laryngorhinootologie 1999
  14. Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Win- born KY, et al. Pharmacological and immunohistochemical chara- cterization of the APJ receptor an