AI Summary & Key Takeaways
AI InsightIn this report, we aimed to point out that MFS is a cause of seconder osteoporosis and the reason for developing osteoporosis in general by examining the case where a 29 year old male MFS patient who visited our outpatient clinics with complaints of low back, and right leg pain exhibited decrease in BMD. (Turkish Journal of Osteoporosis 2012;18: 68-71)
📌 3 Key Takeaways
Abstract
Marfan syndrome (MFS) is an autosomal dominant disorder developing as a result of mutation of fibrillin-1 gene located on chromosome 15. This collagen vascular disease causes multisystem abnormalities involving musculoskeletal, cardiovascular, ocular, and neurologic systems. MFS also causes secondary osteoporosis, and leads to a decrease in bone mineral density (BMD), and an increase in fracture risk. In this report, we aimed to point out that MFS is a cause of seconder osteoporosis and the reason for developing osteoporosis in general by examining the case where a 29 year old male MFS patient who visited our outpatient clinics with complaints of low back, and right leg pain exhibited decrease in BMD. (Turkish Journal of Osteoporosis 2012;18: 68-71)
Özet
Marfan sendromu (MFS) 15. krozomdaki fibrillin-1 gen mutasyonu sonucu gelişen otozomal dominat bir hastalık olup, kas-iskelet sistemi, kardiyovasküler, oküler ve nörolojik sistem problemlerine sebep olan multisistemik bir bağ dokusu hastalığıdır. MFS ayrıca sekonder osteoporoz nedeni olup, kemik mineral yoğunluğunda (KMY) azalma ve kırık riskinde artışa yol açar. Bu yazıda bel ve sağ bacakta ağrı yakınması ile polikliniğimize başvuran 29 yaşındaki erkek hastanın yapılan KMY ölçümünde azalma tespit edilmesi nedeniyle MFS’nin sekonder osteoporoz nedenlerinden biri olduğuna ve osteoporoz gelişiminin sebeplerine dikkati çekmek amaçlanmıştır. (Türk Osteoporoz Dergisi 2012;18: 68-71)