Journals / Türk Osteoporoz Dergisi / 2020 / Cilt: 26 - Sayı: 2

Paget’s Disease Diagnosed on Cranial and Sacroiliac Involvement in Contrast to Normal Alkaline Phosphatase Levels

Kraniyal ve Sakroiliak Tutulum ile Tanı Konulan Alkalen Fosfatazın Normal Olduğu Paget Hastalığı

Pages
136–138
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Here, I present the case of an 80-year-old mansuffering from chronic low back pain, and diagnosed as Paget’s disease, with normal serum alkaline phosphatase and bone-specific alkalinephosphatase levels.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Paget’s disease of bone is characterized by a chronic focal bone remodelling disorder, which is usually detected incidentally during routineimagining examinations.
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Key Findings & Data:Although the measurement of total serum alkaline phosphatase usually provides a general indication of boneturnover in Paget’s disease, about 10-15% of patients present with alkaline phosphatase levels within the normal range.
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Conclusion & Impact:Here, I present the case of an 80-year-old mansuffering from chronic low back pain, and diagnosed as Paget’s disease, with normal serum alkaline phosphatase and bone-specific alkalinephosphatase levels.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Paget’s disease of bone is characterized by a chronic focal bone remodelling disorder, which is usually detected incidentally during routineimagining examinations. Although the measurement of total serum alkaline phosphatase usually provides a general indication of boneturnover in Paget’s disease, about 10-15% of patients present with alkaline phosphatase levels within the normal range. The treatment ofsymptomatic forms relies on bisphosphonates that are efficient in reducing the bone turnover. Here, I present the case of an 80-year-old mansuffering from chronic low back pain, and diagnosed as Paget’s disease, with normal serum alkaline phosphatase and bone-specific alkalinephosphatase levels.

Özet

Kemiğin Paget hastalığı, genellikle radyolojik incelemelerde tesadüfen tespit edilen kronik fokal kemik yapılanma bozukluğu ile karakterizedir. Her ne kadar serum total alkalen fosfataz Paget hastalığında genel bir kemik döngüsü belirteci olsa da, hastaların yaklaşık %10-15’inde referans aralığında bulunur. Semptomatik formların tedavisi, kemik döngüsündeki yükselmeleri azaltmakta etkili olan bifosfonatlar ile sağlanır. Burada kronik bel ağrısı olan ve normal serum alkalen fosfataz ve kemik spesifik alkalen fosfataz düzeyleri ile Paget hastalığı tanısı alan 80 yaşında bir olgu sunulmaktadır.

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Cite This Article

SAĞLAM, G. (2022). Paget’s Disease Diagnosed on Cranial and Sacroiliac Involvement in Contrast to Normal Alkaline Phosphatase Levels. Türk Osteoporoz Dergisi, Cilt: 26 - Sayı: 2, 136–138. https://ajindex.com/articles/639658

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