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Journals / Türk Osteoporoz Dergisi / 2015 / Cilt: 21 - Sayı: 3

Diffuse Idiopathic Skeletal Hyperosteosis: A Review

Yaygın İdiyopatik İskelet Hiperostozu: Derleme

Sevgi İkbali AFŞAR
Pages
132–136
Publication Date
2022-11-04
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The aim of this study was to summarize new pathogenetic, clinical and therapeutic insights of this disease, based on published literature

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Diffuse idiopathic skeletal hyperosteosis (DISH) is also known as Forestier disease and is a systemic non-inflammatory disorder seen more commonly in males and elderly.
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Key Findings & Data:It is characterized by calcification of the anterior longitudinal ligament of the vertebral column and various extraspinal ligaments.
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Conclusion & Impact:The aim of this study was to summarize new pathogenetic, clinical and therapeutic insights of this disease, based on published literature
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Diffuse idiopathic skeletal hyperosteosis (DISH) is also known as Forestier disease and is a systemic non-inflammatory disorder seen more commonly in males and elderly. It is characterized by calcification of the anterior longitudinal ligament of the vertebral column and various extraspinal ligaments. It is usually asymptomatic while the most common symptoms are spinal pain, limited range of spinal motion and dysphagia due to esophagus compression. The etiopathogenesis is not clear. It is commonly seen together with diabetes mellitus, obesity, hyperinsulinemia, hypertension and lipid and purine metabolism disorders, indicating an association with metabolic disorders. Recent studies have emphasized that the pathological calcification of the anterior longitudinal ligament plays a role in the pathophysiology. The aim of this study was to summarize new pathogenetic, clinical and therapeutic insights of this disease, based on published literature

Özet

Forestier hastalığı olarak da bilinen yaygın idiyopatik iskelet hiperostozu (YİİH) erkeklerde ve yaşlı popülasyonda daha sık görülen, enflamatuvar olmayan, sistemik bir hastalıktır. Vertebral kolonun anterior longitudinal ligamenti ve çeşitli ekstraspinal ligamentlerin ossifikasyonu ile karakterizedir. Çoğunlukla asemptomatik seyretmekle birlikte, en sık görülen belirtiler omurgada ağrı, hareket kısıtlılığı ve özefagus kompresyonuna bağlı disfajidir. Hastalığın etyopatogenezi tam olarak netlik kazanmamıştır. Genellikle diyabetes mellitus, obezite, hiperinsülinemi, hipertansiyon, lipid ve pürin metabolizması bozuklukları ile birlikte olması, metabolik durumlarla ilişkili olduğunu düşündürmüştür. Son yıllarda yapılan çalışmalarda, hastalığın patofizyolojisinde anterior longitudinal ligamentte oluşan patolojik kalsifikasyonun rol oynadığı üzerinde durulmuştur. Bu makalede, literatürün derlemesi yapılarak, YİİH ile ilgili yeni patogenetik, klinik ve terapötik yaklaşımların özetlenmesi amaçlanmıştır

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Cite This Article

AFŞAR, S. İ. (2022). Diffuse Idiopathic Skeletal Hyperosteosis: A Review. Türk Osteoporoz Dergisi, Cilt: 21 - Sayı: 3, 132–136. https://ajindex.com/articles/639789

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