SavedAdd your journal

Journals / Türk Osteoporoz Dergisi / 2017 / Cilt: 23 - Sayı: 2

Osteoporotic Vertebral Fractures, Secondary Developing to Long Term Glucocorticoid and Cyclosyporin-A Use: A Case Report

Uzun Dönem Glukokortikoid ve Siklosporin-A Kullanımına Sekonder Gelişen Osteoporotik Vertebra Fraktürleri: Olgu Sunumu

Rana TERLEMEZ
Banu KURAN
Jülide ÖNCÜ ALPTEKİN
Figen YILMAZ
Cansu MERT
Selda ÇİFTCİ
Zehra DUMAN
Pages
75–78
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

To sum up, this case shows that steroids and combination treatments should be used with appropriate dose and duration in absolute indications and patients should be monitored in order

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Many side effects are encountered during the use of glucocorticoids.
📊
Key Findings & Data:The side effect increase with high dose and long-term use of steroids.
💡
Conclusion & Impact:To sum up, this case shows that steroids and combination treatments should be used with appropriate dose and duration in absolute indications and patients should be monitored in order
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Many side effects are encountered during the use of glucocorticoids. Osteoporosis is a common side effect of bone metabolism. The side effect increase with high dose and long-term use of steroids. In this article, we report a case of uncontrolled glucocorticoid use for 6 years due to ocular involvement due to Behçet’s disease and a young male with osteoporotic fracture of the dorsal and lumbar vertebrae due to cyclosporine use for 3 years. To sum up, this case shows that steroids and combination treatments should be used with appropriate dose and duration in absolute indications and patients should be monitored in order

Özet

Glukokortikoid kullanımı sırasında pek çok yan etkiyle karşılaşılmaktadır. Osteoporoz kemik metabolizması üzeri sık görülen yan etkisidir. Yüksek dozda ve uzun süreli steroid kullanımı sırasında yan etki artar. Bu yazımızda, Behçet hastalığına bağlı göz tutulumu nedeniyle yaklaşık 6 yıldır kontrolsüz glukokortikoid ve 3 yıldır siklosporin kullanımı sonucu dorsal ve lomber vertebralarda osteoporotik fraktür gelişen genç erkek bir olgu sunulmuştur. Sonuç olarak bu olgu, steroidlerin ve kombinasyon tedavilerinin gerekli endikasyonlarda, uygun doz ve süreyle kullanılmasını, hastaların düzenli takip edilmelerinin gerektiğini göstermiştir

🔖

Cite This Article

TERLEMEZ, R., KURAN, B., ALPTEKİN, J. Ö., YILMAZ, F., MERT, C., ÇİFTCİ, S., DUMAN, Z. (2022). Osteoporotic Vertebral Fractures, Secondary Developing to Long Term Glucocorticoid and Cyclosyporin-A Use: A Case Report. Türk Osteoporoz Dergisi, Cilt: 23 - Sayı: 2, 75–78. https://ajindex.com/articles/639710

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (18)

  1. Fardet L, Kassar A, Cabane J, Flahault A. Corticosteroid-induced adverse events in adults:frequency, screening and prevention. Drug Saf 2007;10:861-81
  2. Deogelaer JP. Glucocorticoid-induces osteoporosis: mechanisms and therapeutic approach. Rheum Dis Clin North Am 2006;32:733- 57
  3. Yalçın P. Glukokortikoid osteoporozu. Romatizma 2000;15:145- 50
  4. Legand E, Audran M, Guggenbuhl P, Levasseur R, Chales G, Basle MF, et al. Trabecular bone microarchitecture is related to number of risk factors and etiology in osteoporotic men. Microsc Res Tech 2007;70:952-9
  5. De Vries F, Bracke M, Leufkens HG, Lammers JW, Cooper C, Van Staa TP. Fracture risk with intermittent high-dose oral glucocorticoid therapy. Arthritis Rheum 2007;56:2008-14
  6. Yeo H, Beck LH, McDonald JM, Zayzafoon M. Cyclosporin A elicits dose-dependent biphasic effects on osteoblast differentiation and bone formation. Bone 2007;40:1502-16
  7. Tetikoğlu M, Erdokur O, Mudun A, Tunç Y, Elçioğlu NE. Behçet üveiti tedavisinde Siklosporin A kullanımının etkinliği ve güvenilirliği. Turk J Ophthalmol 2008;38:389-92
  8. Hız Ö, Karaaslan G, Yazmalar L, Tekeoğlu İ. Uzun dönem glukokortikoid kullanımına bağlı gelişen manifest osteoporoz ve sağ femur başı avasküler nekroz birlikteliği:Olgu sunumu. Van Tıp Dergisi 2008;15:90-4
  9. Shipley M, Black CM, Dentom CP, Compston J, O’Gradaigh D. Romatoloji ve kemik hastalıkları. İçinde: Kumar P, Clark M, editors. Clinical Medicine (F. Tabak, Ö. Tabak; Çev.
  10. Baskı. İstanbul Tıp Kitabevi; 2010. p. 584-5
  11. Sakane T, Takeno M, Suzuki N, Inaba G. Behçet’s disease. N Engl J Med 1999;341:1284-91
  12. Özyazgan Y. Ocular Involvement in Behcet’s Disease. Turkderm 2009;43:48-53
  13. Tugal-Tutkun I, Onal S, Altan-Yaycioglu R, Huseyin Altunbas H, Urgancioglu M. Uveitis in Behçet’s disease: an analysis of 880 patients. Am J Ophthalmol 2004;138:373-80
  14. Mochizuki M, Akduman L, Nusenblatt RB. Behçet’s disease. In: Pe pose JS, Holland GN, Wilhelmus KR, editors. Ocular infection and im- munity. St Louis: Mosby; 1996. p. 663-75
  15. Orwoll ES, Klein RF. Osteoporosis in men. Endocr Rev 1995;16:87- 116
  16. Kelepouris N, Harper KD, Gannon F, Kaplan FS, Haddad JG. Severe osteoporosis in men. Ann Intern Med 1995;123:452-60
  17. Seeman E, Mellon LJ 3rd, O’Fallon WM, Riggs BL. Risk factors for spinal osteoporosis in men. Am J Med 1983;75:977-83
  18. Kanis JA, Johnell O, De Laet C, Johansson H, Oden A, Delmas P, et al. A meta-analysis of previous fracture and subsequent fracture r