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Journals / Türk Osteoporoz Dergisi / 2018 / Cilt: 24 - Sayı: 2

Pathological Femoral Fracture due to Osteoporosis and Hypophosphatemic Osteomalacia Following Adefovir Therapy in a Patient with Chronic Hepatitis B

Kronik Hepatit B’li Hastada Adefovir Tedavisi Sonrası Gelişen Osteoporoz ve Hipofosfatemik Osteomalaziye Bağlı Patolojik Femur Kırığı

Duygu GELER KÜLCÜ
Zerrin ŞAHİN
Nilgün MESCİ
Sevilay BATIBAY
Borçak ÇAĞLAR RUHİ
Hasan GÜNDOĞDU
Pages
59–62
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We aimed to report a 55-year-old male patient with proximal femur fracture who developed hypophosphatemic osteomalacia while using low dose of adefovir (10 mg/day) for chronic hepatitis B treatment for 10 years.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Adefovir dipivoxil (ADV) is a nucleotide analogue used in the chronic hepatitis B treatment.
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Key Findings & Data:Proximal renal tubular dysfunction is one of the adverse effects of this agent and characterized with hypophosphatemia and osteomalacia.
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Conclusion & Impact:We aimed to report a 55-year-old male patient with proximal femur fracture who developed hypophosphatemic osteomalacia while using low dose of adefovir (10 mg/day) for chronic hepatitis B treatment for 10 years.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Adefovir dipivoxil (ADV) is a nucleotide analogue used in the chronic hepatitis B treatment. Proximal renal tubular dysfunction is one of the adverse effects of this agent and characterized with hypophosphatemia and osteomalacia. However, reduced bone mineral density with fracture due to ADV therapy has not been reported before. We aimed to report a 55-year-old male patient with proximal femur fracture who developed hypophosphatemic osteomalacia while using low dose of adefovir (10 mg/day) for chronic hepatitis B treatment for 10 years.

Özet

Adefovir dipivoksil (ADV), kronik hepatit tedavisinde kullanılan bir nükleotid analoğudur. Proksimal renal tübüler fonksiyon bozukluğu, bu ajanın yan etkilerinden biridir ve hipofosfatemi ve osteomalazi ile karakterizedir. Bununla birlikte, ADV tedavisine bağlı kırık ile kemik mineral dansitesinde azalma daha önce bildirilmemiştir. Burada 10 yıldır kronik hepatit B tedavisi için düşük dozda adefovir kullanan (10 mg/gün) 55 yaşındaki erkek hastada hipofosfatemik osteomalazi sonucu gelişen proksimal femur kırığı olan bir hastayı bildirmeyi amaçladık.

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Cite This Article

KÜLCÜ, D. G., ŞAHİN, Z., MESCİ, N., BATIBAY, S., RUHİ, B. Ç., GÜNDOĞDU, H. (2022). Pathological Femoral Fracture due to Osteoporosis and Hypophosphatemic Osteomalacia Following Adefovir Therapy in a Patient with Chronic Hepatitis B. Türk Osteoporoz Dergisi, Cilt: 24 - Sayı: 2, 59–62. https://ajindex.com/articles/639693

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References (13)

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