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Journals / Türk Osteoporoz Dergisi / 2020 / Cilt: 26 - Sayı: 2

Serum Melatonin Levels in Patients with Family Mediterranean Fever

Ailevi Akdeniz Ateşi Olan Hastalarda Serum Melatonin Düzeyleri

Nurinnisa ÖZTÜRK
Ayhan KUL
Köksal SARIHAN
Fatih Baygutalp
Pages
92–97
Publication Date
2022-11-06
DOI
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In addition, the relationship between serum MLT level and disease severity was evaluated.Results: A significant difference was observed between the groups in terms of serum MLT levels (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Melatonin (MLT) has been reported to play a role in the immunopathogenesis and aetiology of many chronic inflammatory diseases.
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Key Findings & Data:Therefore, we aimed to investigate the possible relationship between disease severity and serum MLT levels in patients with Familial Mediterranean fever (FMF).Materials and Methods: A total of 30 patients diagnosed with FMF who had experienced no episodes for at least 1 month (mean age, 36.4±12.2 years; range, 19-68 years), including 14 men and 16 women, and 30 healthy controls (mean age, 38.4±12.5 years; range, 19-65 years), 12 men and 18 women, matched for age and gender, were included in this study.
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Conclusion & Impact:In addition, the relationship between serum MLT level and disease severity was evaluated.Results: A significant difference was observed between the groups in terms of serum MLT levels (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Melatonin (MLT) has been reported to play a role in the immunopathogenesis and aetiology of many chronic inflammatory diseases. Therefore, we aimed to investigate the possible relationship between disease severity and serum MLT levels in patients with Familial Mediterranean fever (FMF).Materials and Methods: A total of 30 patients diagnosed with FMF who had experienced no episodes for at least 1 month (mean age, 36.4±12.2 years; range, 19-68 years), including 14 men and 16 women, and 30 healthy controls (mean age, 38.4±12.5 years; range, 19-65 years), 12 men and 18 women, matched for age and gender, were included in this study. Demographic data, laboratory data and clinical characteristics of the participants were recorded and serum MLT levels were determined. In addition, the relationship between serum MLT level and disease severity was evaluated.Results: A significant difference was observed between the groups in terms of serum MLT levels (p

Özet

Amaç: Melatoninin (MLT) birçok kronik enflamatuvar hastalığın immünopatogenezinde ve etiyolojisinde rol oynayabileceği bildirildiğinden dolayı, çalışmamızda ailevi akdeniz ateşi (AAA) olan hastaların serum MLT seviyelerinin belirlenerek hastalık şiddeti ile arasında olası bir ilişki olup olmadığını incelemeyi amaçladık. Gereç ve Yöntem: Çalışmaya AAA hastalığı tanısı konulan ve en az 1 aydır (ortalama yaş, 36,4±12,2 yıl; aralık, 19-68 yıl) atak geçirmeyen 14 erkek ve 16 kadın olmak üzere toplam 30 hasta (ortalama yaş, 38,4±12,5 yıl; aralık, 19-65 yıl) ile yaş ve cinsiyetleri benzer olan 12 erkek ve 18 kadın toplam 30 sağlıklı kontrol (ortalama yaş 38,4±12,5 yıl; yaş aralığı; 19-65 yıl) bulunmaktaydı. Katılımcıların demografik verileri, laboratuvar ve klinik özellikleri kaydedilerek, serum MLT seviyeleri belirlendi. Ayrıca serum MLT seviyesi ile hastalık şiddeti arasındaki ilişki değerlendirildi. Bulgular: Gruplar arasında serum MLT seviyeleri açısından anlamlı fark olduğu belirlendi (p

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Cite This Article

ÖZTÜRK, N., KUL, A., SARIHAN, K., Baygutalp, F. (2022). Serum Melatonin Levels in Patients with Family Mediterranean Fever. Türk Osteoporoz Dergisi, Cilt: 26 - Sayı: 2, 92–97. https://ajindex.com/articles/639627

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References (15)

  1. Sarı İ, Birlik M, Kasifoğlu T. Familial Mediterranean fever: An updated review. Eur J Rheumatol 2014;1:21-33
  2. Stehlik C, Reed JC. The PYRIN connection: novel players in innate immunity and inflammation. J Exp Med 2004;200:551-8
  3. Simon A, van der Meer JWM. Pathogenesis of familial periodic fever syndromes or hereditary autoinflammatory syndromes. Am J Physiol Regul Integr Comp Physiol 2007;292:R86-98
  4. Gang N, Drenth JP, Langevitz P, Zemer D, Brezniak N, Pras M, et al. Activation of the cytokine network in familial Mediterranean fever. J Rheumatol 1999;26:890-7
  5. Sahin A, Erten S, Altunoglu A, Isikoglu S, Neselioglu S, Ergin M, et al. Comparison of serum oxidant and antioxidant parameters in familial Mediterranean fever patients (FMF) with attack free period. Acta Reumatol Port 2014;39:316-21
  6. Vgontzas AN, Chrousos GP. Sleep, the hypothalamic-pituitary-adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders. Endocrinol Metab Clin North Am 2002;31:15-36
  7. Mormont MC, Levi F. Circadian-system alterations during cancer processes: a review. Int J cancer 1997;70:241-7
  8. Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H. Control mechanism of the circadian clock for timing of cell division in vivo. Science 2003;302:255-9
  9. Korkmaz A. Melatonin as an adjuvant therapy in patients with rheumatoid arthritis. Br J Clin Pharmacol 2008;66:316-7
  10. Forrest CM, Mackay GM, Stoy N, Stone TW, Darlington LG. Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin. Br J Clin Pharmacol 2007;64:517-26
  11. Ha E, Choe B-K, Jung KH, Yoon SH, Park HJ, Park HK, et al. Positive relationship between melatonin receptor type 1B polymorphism and rheumatoid factor in rheumatoid arthritis patients in the Korean population. J Pineal Res 2005;39:201-5
  12. Reiter RJ. Melatonin: clinical relevance. Best Pract Res Clin Endocrinol Metab 2003;17:273-85
  13. Musabak U, Kilciler G, Uygun A, Kantarcıoglu M, Polat Z, Sagkan RI, et al. Melatonin and Its Day and Night Rhythm of Alterations in Familial Mediterranean Fever: A Brief Research Letter. Open Rheumatol J 2011;5:13-7
  14. Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 1997;40:1879-85
  15. Pras E, Livneh A, Balow JEJ, Pras E, Kastner DL, Pras M, et al. Clinical differences between North African and Iraqi Jews with familial Mediterranean fever. Am J Med