Journals / Türk Osteoporoz Dergisi / 2021 / Cilt: 27 - Sayı: 1

Brown Tumor and Hyperparathyroidism in Orthopaedic Surgery

Ortopedide Brown Tümörü ve Hiperparatiroidizme Yaklaşım

Pages
24–29
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In order to make a definitive diagnosis for the cystic and lytic lesions, suspecting the patient’s clinical status and keeping any possible diagnosis in mind is necessary.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: This study aimed a better diagnosis for patients with primary hyperparathyroidism (PHPT), who could be referred to misdiagnosis and treatment and be able to demonstrate a well analysis of patient before orthopaedic surgery.Materials and Methods: A total of 12 patients admitted to our orthopaedics outpatient clinic between 2003 and 2017, examined and treated due to the bone lesion or fracture and diagnosed with PHPT, were included in this study.
📊
Key Findings & Data:Direct radiograph was used to follow cysts recession after adenectomy.Results: Patients have the mean age of 36.6±13.4 years, wherein seven were female and five were male.
💡
Conclusion & Impact:In order to make a definitive diagnosis for the cystic and lytic lesions, suspecting the patient’s clinical status and keeping any possible diagnosis in mind is necessary.
🔬Design:Research Article
📍Scope:2003 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: This study aimed a better diagnosis for patients with primary hyperparathyroidism (PHPT), who could be referred to misdiagnosis and treatment and be able to demonstrate a well analysis of patient before orthopaedic surgery.Materials and Methods: A total of 12 patients admitted to our orthopaedics outpatient clinic between 2003 and 2017, examined and treated due to the bone lesion or fracture and diagnosed with PHPT, were included in this study. Patients were referred to the general surgery clinic for adenectomy. Direct radiograph was used to follow cysts recession after adenectomy.Results: Patients have the mean age of 36.6±13.4 years, wherein seven were female and five were male. Individual bone involvement was observed in three patients, whereas nine patients had multiple bone involvement. Eight patients had pathological fractures. Biopsy was conducted on all patients, revealing an increased osteoclastic activity and multinuclear giant cells, and a report was issued for these findings.Conclusion: Brown tumor is very rare reactive lesions developed in bone tissues during hyperparathyroidism. In order to make a definitive diagnosis for the cystic and lytic lesions, suspecting the patient’s clinical status and keeping any possible diagnosis in mind is necessary.

Özet

Amaç: Primer hiperparatiroidizmi (PHPT) olup yanlış tanı ve tedaviye yönlendirilebilecek hastalar için, ortopedik cerrahi öncesinde daha iyi analiz edilmesine yol gösterecek bir çalışma planladık. Gereç ve Yöntem: 2003-2017 yılları arasında ortopedi polikliniğimize başvuran, kemik lezyonu veya kırığı nedeniyle muayene edilip tedavi edilen ve PHPT tanısı alan 12 hasta çalışmaya alındı. Hastalar adenektomi için genel cerrahi kliniğine sevk edildi. Adenektomi sonrası kistlerin durgunluğunu takip etmek için direkt radyografi kullanıldı. Bulgular: Hastaların ortalama yaşı 36,6±13,4 yıl idi. Çalışmaya dahil edilen hastaların 7’si kadın, 5’i erkekti. Üç hastada bireysel kemik tutulumu gözlenirken, 9 hastada çoklu kemik tutulumu gözlendi. Sekiz hastada patolojik kırık vardı. Artmış osteoklastik aktivite ve çok çekirdekli dev hücreler gösteren tüm hastalara biyopsi yapıldı ve bu bulgular için bir rapor yayınlandı. Sonuç: Brown tümör, hiperparatiroidizm sırasında kemik dokularında gelişen çok nadir reaktif lezyonlardır. Kistik ve litik lezyonlar için kesin bir tanı koymak için, hastanın klinik durumundan şüphelenmek ve olası herhangi bir tanıyı akılda tutmak gerekir.

🔖

Cite This Article

ÖZDEMİR, H. M., Gültekin, O., ÖÇ, Y., KILINÇ, B. E., YAZAR, E. A., VAROL, A. (2022). Brown Tumor and Hyperparathyroidism in Orthopaedic Surgery. Türk Osteoporoz Dergisi, Cilt: 27 - Sayı: 1, 24–29. https://ajindex.com/articles/639605

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Bilezikian JP, Brandi ML, Rubin M, Silverberg SJ. Primary hyperparathyroidism: new concepts in clinical, densitometric and biochemical features. J Intern Med 2005;257:6-17
  2. Parisien M, Silverberg SJ, Shane E, Dempster DW, Bilezikian JP. Bone disease in primary hyperparathyroidism. Endocrinol Metab Clin North Am 1990;19:19-34
  3. Ishikawa S, Ozaki T, Kawai A, Inoue H, Doihara H. Hyperparathyroid crisis in a patient with a giant brown tumor of the iliac bone: a case report. Hiroshima J Med Sci 1998;47:27-30
  4. Favus MJ. Primer on Metabolic Bone Diseases and Disorders of Mineral Metabolism. 2th ed. Lippincott - Raven; 1993
  5. Mirra JM, Campanacci M, Picci P. Brown tumor of hyperparathyroidism. In: Mirra JM, editor. Bone Tumors. Lea & Febiger; 1989. p. 1785-801
  6. Peimer CA, Moy OJ, Dick HM. Tumors of bone and soft tissue. In: Green DP, editor. Operative hand surgery. New York: Churchill Livingstone; 1992. p. 2225-50
  7. Morano S, Cipriani R, Gabriele A, Medici F, Pantellini F. Recurrent brown tumors as initial manifestation of primary hyperparathyroidism. An unusual presentation. Minerva Med 2000;91:117-22
  8. Aoune S, Khochtali H, Dahdouh C, Turki A, Mokni M, Bakir A. Giant cell lesions of the maxilla disclosing primary hyperparathyroidism. Rev Stomatol Chir Maxillofac 2000;101:86-9
  9. Cicconetti A, Matteini C, Piro FR. Differential diagnosis in a case of brown tumor caused by primary hyperparathyroidism. Minerva Stomatol 1999;48:553-8
  10. Pezzillo F, Di Matteo R, Liuzza F, Visci F, Callà C, Rosa MA, et al. Isolated bone lesion secondary to hyperparathyroidism: diagnostic considerations. Clin Ter 2008;159:265-8
  11. Jouan A, Zabraniecki L, Vincent V, Poix E, Fournié B. An unusual presentation of primary hyperparathyroidism: severe hypercalcemia and multiple brown tumors. Joint Bone Spine 2008;75:209-11
  12. Panagopoulos A, Tatani I, Kourea HP, Kokkalis ZT, Panagopoulos K, Megas P. Osteolytic lesions (brown tumors) of primary hyperparathyroidism misdiagnosed as multifocal giant cell tumor of the distal ulna and radius: a case report. J Med Case Rep 2018;12:176
  13. Vera L, Dolcino M, Mora M, Oddo S, Gualco M, Minuto F, et al. Primary hyperparathyroidism diagnosed after surgical ablation of a costal mass mistaken for giant-cell bone tumor: a case report. J Med Case Rep 2011;5:596
  14. Rossi B, Ferraresi V, Appetecchia ML, Novello M, Zoccali C. Giant cell tumor of bone in a patient with diagnosis of primary hyperparathyroidism: a challenge in differe