SavedAdd your journal

Journals / Türk Onkoloji Dergisi / 2020 / Cilt: 35 - Sayı: 1

Is there any Relation between the Type of Surgery and Radiation Induced Non-rectal Bowel Toxicity in Patients with Gynecologic Cancer Receiving Adjuvant Radiotherapy?

Meltem DAĞDELEN
İsmet ŞAHİNLER
Şefika Arzu ERGEN
Ceren BARLAS
Pages
78–86
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, due to the small number ofpatients, prospective studies with large sample sizes are needed for the correct interpretation.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:OBJECTIVEDosimetric and clinical comparison of the effects of surgical type on the risk of developing radiationinduced non-rectal bowel toxicity in patients with gynecologic cancer who have received adjuvant radiotherapy.METHODS36 patients who meet study criteria were retrospectively evaluated and classified as laparoscopy (group1) and open surgery (group 2).
📊
Key Findings & Data:Intestinal volumes that received a 10% range of total radiotherapy doseat 10% (V10%) to 100% (V100%) and dosimetric data (V40-45 Gy, Dmax.) were obtained from the dosevolume histogram.
💡
Conclusion & Impact:However, due to the small number ofpatients, prospective studies with large sample sizes are needed for the correct interpretation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVEDosimetric and clinical comparison of the effects of surgical type on the risk of developing radiationinduced non-rectal bowel toxicity in patients with gynecologic cancer who have received adjuvant radiotherapy.METHODS36 patients who meet study criteria were retrospectively evaluated and classified as laparoscopy (group1) and open surgery (group 2). Intestinal volumes that received a 10% range of total radiotherapy doseat 10% (V10%) to 100% (V100%) and dosimetric data (V40-45 Gy, Dmax.) were obtained from the dosevolume histogram. The toxicities were graded acute and late according to Radiation Therapy OncologyGroup (RTOG) scoring.RESULTSThe median follow-up was 55 months in group 1 and 37 months in group 2. Grade 2 acute bowel toxicitywas observed in seven patients (38.9%) in group 1 and three patients (16.7%) in group 2. One patient ingroup 1 was diagnosed with ileus as late toxicity requiring surgery.There was no significant differencebetween the groups concerning surgical type and toxicity development.CONCLUSIONA similar risk of developing radiation-induced non-rectal bowel toxicity in patients who underwentlaparoscopic or open surgery has been demonstrated in this study. However, due to the small number ofpatients, prospective studies with large sample sizes are needed for the correct interpretation.

🔖

Cite This Article

DAĞDELEN, M., ŞAHİNLER, İ., ERGEN, Ş. A., BARLAS, C. (2022). Is there any Relation between the Type of Surgery and Radiation Induced Non-rectal Bowel Toxicity in Patients with Gynecologic Cancer Receiving Adjuvant Radiotherapy?. Türk Onkoloji Dergisi, Cilt: 35 - Sayı: 1, 78–86. https://ajindex.com/articles/639144

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (9)

  1. Kuku SY. Radiation-Induced Bowel Injury (RIBI): Exploring potential predictive and prognostic factors and strategies to improve the management of women treated with Pelvic Radiation for Cervical and Endometrial Cancers: Cancer Survivorship: Improving Quality of Life after Treatment for Gynaecological Cancers: University College London (UCL); 2015
  2. National Cancer Institute. Radiation enteritis. Available at: http:// www.cancer.gov/about-cancer/treatment/side-effects/constipation/GI-complications-hppdq#section/_193. Accessed May 24, 2018
  3. Chen SW, Liang JA, Yang SN, Hung YC, Yeh LS, Shiau AC, et al. Radiation injury to intestine following hysterectomy and adjuvant radiotherapy for cervical cancer. Gynecol Oncol 2004;95(1):208–14
  4. Huang EY, Wang CJ, Hsu HC, Hao Lin, Chen HC, Sun LM. Dosimetric factors predicting severe radiation-induced bowel complications in patients with cervical cancer: combined effect of external parametrial dose and cumulative rectal dose. Gynecol Oncol 2004;95(1):101–8
  5. Kasibhatla M, Clough RW, Montana GS, Oleson JR, Light K, Steffey BA, et al. Predictors of severe gastrointestinal toxicity after external beam radiotherapy and interstitial brachytherapy for advanced or recurrent gynecologic malignancies. Int J Radiat Oncol Biol Phys 2006;65(2):398–403
  6. Potish RA, Jones TK Jr, Levitt SH. Factors predisposing to radiation-related small-bowel damage. Radiology 1979;132(2):479–82
  7. Gouy S, Morice P, Narducci F, Uzan C, Martinez A, Rey A, et al. Prospective multicenter study evaluating the survival of patients with locally advanced cervical cancer undergoing laparoscopic para-aortic lymphadenectomy before chemoradiotherapy in the era of positron emission tomography imaging. J Clin Oncol 2013;31(24):3026–33
  8. Marnitz S, Schram J, Budach V, Sackerer I, Vercellino GF, Sehouli J, et al. Extended field chemoradiation for cervical cancer patients with histologically proven para-aortic lymph node metastases after laparaoscopic lymphadenectomy. Strahlenther Onkol 2015;191(5):421–8
  9. Ghezzi F, Cromi A, Serati M, Uccella S, Formenti G, Bogani G, et al. Radiation-induced bowel complications: laparoscopic versus open staging of gynecologic malignancy. Ann Surg Oncol 2011;18(3):782–91. 10.Eifel PJ, Klopp AH. Gynecologic Radiation Oncology: A Practical Guide: Lippincott Williams&Wilkins; 2016. 11.Nezhat C, Siegler A, Farr Nezhat F, Ceana Nezhat C, Daniel Seidman S, Luciano A. Operative gynecologic laparoscopy: principles and techn