Molecular Biology of Pituitary Adenomas

Objective & Hypothesis:The tumorigenesis of pituitary adenomas is a complex multistep process in which many genetic and epigenetic changes, internal and external factors are involved.

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Key Findings & Data:Oncogenes, tumor suppressor genes, cell cycle elements, genetic mutations, epigenetic modifications, microRNAs play role in this process.

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Conclusion & Impact:In this review, we will focus on the oncogenes, tumor suppressor genes, cell cycle elements and microRNAs which have role in tumorigenesis process.

🔬Design:Review & Systematic Survey

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

The tumorigenesis of pituitary adenomas is a complex multistep process in which many genetic and epigenetic changes, internal and external factors are involved. Oncogenes, tumor suppressor genes, cell cycle elements, genetic mutations, epigenetic modifications, microRNAs play role in this process. In this review, we will focus on the oncogenes, tumor suppressor genes, cell cycle elements and microRNAs which have role in tumorigenesis process.

Özet

Hipofiz adenomlarında tümörogenez çok basamaklı olup genetik ve epigenetik değişiklikler ile birçok iç ve dış faktörün yer aldığı karmaşık bir süreçtir. Bu süreçte onkogenler, tümör baskılayıcı genler, hücre döngüsü elemanları, genetik mutasyonlar, epigenetik modifikasyonlar, mikroRNA'lar rol oynamaktadır. Bu derlemede, tümörogenez sürecinde rolü olan onkogenler, tümör baskılayıcı genler, hücre döngüsü elemanlarına değinilerek mikroRNA'lar üzerinde durulacaktır.

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Cite This Article

CEYLAN, S., ANIK, İ., ÇABUK, B., AKKOYUNLU, D. S. (2022). Molecular Biology of Pituitary Adenomas. Türk Nöroşirürji Dergsi, Cilt: 27 - Sayı: 2, 185–190. https://ajindex.com/articles/637434

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