Journals / Türk Nöroşirürji Dergsi / 2017 / Cilt: 27 - Sayı: 1

Treatment Options for Posterior Fossa Astrocytomas

Posterior Fossa Astrositomlarında Tedavi Seçenekleri

Pages
24–30
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In recent years, survival rates are increased due to surgical techniques and technological improvements.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Astrocytomas are glial tumors originating from astrocytic cells and residing in cerebral hemispheres, brainstem, spinal cord or cerebellum.
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Key Findings & Data:According to World Health Organization (WHO), astrocytomas are classified as stage 1-4.
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Conclusion & Impact:In recent years, survival rates are increased due to surgical techniques and technological improvements.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Astrocytomas are glial tumors originating from astrocytic cells and residing in cerebral hemispheres, brainstem, spinal cord or cerebellum. Mostly being benign, they are the most prevalent intracranial tumors in the pediatric age group. According to World Health Organization (WHO), astrocytomas are classified as stage 1-4. In current research, posterior fossa astrocytomas are demonstrated to be monoclonal origin. In surgical treatment; one of the positions from sitting posture, prone and lateral decubitus (park bench) may be preferred. After midline incision, dura is after craniotomy or craniectomy and the lesion is tried to be excised totally. In selected cases, chemotherapy and radiotherapy may be added. The most important factor in prognosis is amount of the excised tumor. After total resection, recurrence is rare. In recent years, survival rates are increased due to surgical techniques and technological improvements.

Özet

Astrositomlar, astrositik hücrelerden köken alan ve serebral hemisferler, beyin sapı, spinal kord veya serebellumda yerleşen glial tümörlerdir. Sıklıkla benign olup, pediatrik yaş grubunda en sık karşılaşılan intrakranial tümörlerdir. Dünya Sağlık Örgütüne (WHO) göre astrositomalar evre 1-4 arasında sınıflandırılmıştır. Güncel çalışmalarda posterior fossa astrositomlarının monoklonal orijinli oldukları gösterilmiştir. Cerrahi tedavide oturur, pron ve lateral dekübit (park-bench) pozisyonlarından biri tercih edilebilir. Orta hat insizyonu sonrası kraniotomi veya kraniektomi yapılarak dura açılır ve lezyon total olarak çıkartılmaya çalışılır. Seçilmiş olgulara kemoterapi ve radyoterapi eklenebilir. Prognozda en önemli faktör tümörün eksizyon miktarıdır. Total rezeksiyon sonrası rekürrens son derece nadirdir. Son yıllarda cerrahi tekniklerin ve teknolojik ilerlemelerin sonucunda sağ kalım oranı daha da artmıştır.

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Cite This Article

KÖKSAL, V., KÜÇÜK, A., GÖRKEM, S. B., ÖKTEM, İ. S. (2022). Treatment Options for Posterior Fossa Astrocytomas. Türk Nöroşirürji Dergsi, Cilt: 27 - Sayı: 1, 24–30. https://ajindex.com/articles/637420

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References (1)

  1. Adams H, Chaichana KL, Avendano J, Liu B, Raza SM, Quinones-Hinojosa A: Adult cerebellar glioblastoma: Understanding survival and prognostic factors using a population-based database from 1973 to 2009. World Neurosurg 80: 237-243, 2013 2. Albright L: Posterior fossa tumors. Neurosurg Clin N Am 3: 881-891, 1992 3. Altınok G, Önol B, Çelik İ, Oruçkaptan H: Analyses of the 45 recurrent cases of supratentorial astrocytomas. Turkish Journal of Pathology 15:5-10, 1998 4. Arslantaş A, Vural M: Serebellar astrositoma. Aksoy K (ed), Temel Nöröşirürji, birinci baskı, Ankara: Türk Nöroşirürji Derneği, 2005:703-709 5. Berkman MZ: Serebellar astrositom. Korfalı E, Zileli M (ed), Temel Nöroşirürji, ikinci baskı, Ankara: Türk Nöroşirürji Derneği, 2010:1057-1110 6. Bernhardtsen T, Laursen H, Bojsen-Moller M, Gjerris F: Sub-classification of low-grade cerebellar astrocytoma: Is it clinically meaningful? Childs Nerv Syst 19:729-735, 2003 7. Chen YH, Gutmann DH: The molecular and cell biology of pediatric low-grade gliomas. Oncogene 33:2019-2026, 2014 8. Di Rocco C: Cerebellar astrocytomas. Choux M, Di Rocco C, Hockley A, Walker M (eds), Pediatric Neurosurgery, birinci baskı, London:Churchill Livingstone, 1999: 427-460 9. Djalilian HR, Hall WA: Malignant gliomas of the cerebellum: An analytic review. J Neurooncol 36:247-257, 1998 10. Due-Tonnessen BJ, Helseth E, Scheie D, Skullerud K, Aamodt G, Lundar T: Long-term outcome after resection of benign cerebellar astrocytomas in children and young adults (0-19 years): Report of 110 consecutive cases. Pediatr Neurosurg 37:71-80, 2002 11. Dunham C: Pediatric brain tumors: A histologic and genetic update on commonly encountered entities. Semin Diagn Pathol 27: 147-159, 2010 12. Erdinçler P, Dalgıç A, Tüzgen S, Çıplak N, Oral Z, Kuday C: Çocukluk çağı posterior fossa tümörleri: 73 olgunun değerlendirilmesi. Türk Nöroşir Derg 12: 31-39, 2002 13. Etuş V: Pediatrik beyin tümörlerinin moleküler biyolojisi. Pediatrik Nöroşirürji. Ankara: Türk Nöroşirürji Derneği, 2014: 389-394 14. Grau E, Balaguer J, Canete A, Martinez F, Orellana C, Oltra S, Hernandez M, Castel V: Subtelomeric analysis of pediatric astrocytoma: Subchromosomal instability is a distinctive feature of pleomorphic xanthoastrocytoma. J Neuro-Oncol 93:175-182, 2009 15. Gronych J, Korshunov A, Bageritz J, Milde T, Jugold M, Hambardzumyan D, Remke M, Hartmann C, Witt H, Jones DT, Witt O, Heiland S, Bendszus M, Holland EC, Pfister S, Lichter P: An activated mutant BRAF kinase