Journals / Türk Nöroşirürji Dergsi / 2020 / Cilt: 30 - Sayı: 2

Brain Immunology and Neuroinflammation in Head Trauma

Beyin İmmünolojisi ve Kafa Travmalarında Nöroinflamasyon

Pages
209–216
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Information on neuroimmunology and its behavior in trauma will be discussed together with the current literature in this article.

📌 3 Key Takeaways

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Objective & Hypothesis:While the central nervous system has been thought to be a structure with limited communication with the immune system for many years, a number of studies in the last 10 years have proven that this is not entirely correct.
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Key Findings & Data:Defining two different and communicating lymphatic systems, which we did not even know existed in the brain, has been a revolutionary development in changing our knowledge.
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Conclusion & Impact:Information on neuroimmunology and its behavior in trauma will be discussed together with the current literature in this article.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

While the central nervous system has been thought to be a structure with limited communication with the immune system for many years, a number of studies in the last 10 years have proven that this is not entirely correct. Defining two different and communicating lymphatic systems, which we did not even know existed in the brain, has been a revolutionary development in changing our knowledge. The gaps in how a number of molecules are transported and how they relate to the immune system are now being filled. Important information has been shared on the explanation of immunological mechanisms in traumatic brain injury (TBI), whose course and outcomes are very variable, with neuroimmunology studies conducted on TBI models in the literature. Information on neuroimmunology and its behavior in trauma will be discussed together with the current literature in this article.

Özet

Merkezi sinir sisteminin, uzun yıllar immün sistem ile iletişimi kısıtlı bir yapı olduğu düşünülürken son 10 yılda bir takım çalışmalarbunun tam olarak doğru olmadığını kanıtlamıştır. Beyinde varlığından bile haberdar olmadığımız, iki farklı ve birbiri ile iletişim halindekilenfatik sistemin tanımlanması bilgilerimizin değişmesinde devrim nitelikli bir gelişme olmuştur. Bir takım moleküllerin nasıl taşındığıve immün sistem ile olan bağlantılarının nasıl olduğu konularındaki boşluklar böylece doldurulmaya başlanmıştır. Literatürdetravmatik beyin yaralanması (TBY) modelleri ile yapılan nöroimmünoloji çalışmaları ile, seyri ve sonuçları çok değişken olan TBY’ndaimmünolojik mekanizmaların açıklanması konusunda önemli bilgiler paylaşılmıştır. Makalede, nöroimmünoloji ve travmadaki seyri ileilgili bilgiler güncel literatür eşliğinde anlatılacaktır.

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Cite This Article

KABATAŞ, S., DIREN, F., CIVELEK, E. (2022). Brain Immunology and Neuroinflammation in Head Trauma. Türk Nöroşirürji Dergsi, Cilt: 30 - Sayı: 2, 209–216. https://ajindex.com/articles/637239

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References (1)

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