Journals / Türk Nöroloji Dergisi / 2008 / Cilt: 14 - Sayı: 2

Evaluating the existence of other autoimmune diseases among multiple sclerosis patients and their first degree relatives

Bir grup multipl skleroz hastasında ve birinci derece akrabalarında ek otoimmün hastalık varlığının araştırılması

Pages
104–110
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

MS and rheumatoid arthritis were observed to be the mostly seen autoimmune diseases among relatives.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: Multiple Sclerosis (MS) is an autoimmune disease that could be seen simultaneously with other diseases with autoimmune origin.OBJECTIVE: In this descriptive study, it was aimed to evaluate the relationship between MS and other autoimmune diseases among MS patients and their first degree relatives in two different centers, Ankara and Samsun.
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Key Findings & Data:METHODS: 784 MS were included in the study.
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Conclusion & Impact:MS and rheumatoid arthritis were observed to be the mostly seen autoimmune diseases among relatives.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: Multiple Sclerosis (MS) is an autoimmune disease that could be seen simultaneously with other diseases with autoimmune origin.OBJECTIVE: In this descriptive study, it was aimed to evaluate the relationship between MS and other autoimmune diseases among MS patients and their first degree relatives in two different centers, Ankara and Samsun. METHODS: 784 MS were included in the study. The data was gathered via interviews and patient record reviews. MS patients and their first degree relatives were asked for 13 specific autoimmune diseases which have been supposed to occur more frequently in MS patients. Data was evaluated seperately as patient record reviews and questionare interview. Ankara and Samsun center results were compared with each other.RESULTS: Among the interviewed subjects, 9 (5.3%) had co-occurrent autoimmune disease while the relatives of 26 (15.3%) was found to have autoimmune disease in Ankara. These figures were respectively 8 (17.4%) and 21 (45.7%) in Samsun. Both comorbid autoimmune disease among patients and autoimmune disease among relatives were observed to be higher in Samsun. Psoriasis was the mostly seen disease in Samsun and one of the mostly seen diseases in Ankara (1.2% in Ankara, 8.7% in Samsun). Multiple sclerosis (5.9%) and rheumatoid arthritis (32.6%) were the mostly seen diseases among relatives in Ankara and Samsun, respectively. According to the patient record reviews, the proportion of comorbid autoimmune disease in MS patients was 2.9% in Ankara and 5.2% in Samsun. In the whole group the proportion of the autoimmune diseases among female patients (17.4%) and their relatives was higher than male patients (5.3%) and their relatives. In Ankara, autoimmune thyroid disease (Graves and Hashimoto disease) was mostly seen whereas Behçet's disease was the most prominent in Samsun. CONCLUSION: In the study it was observed that among MS patients the percentage of having a comorbid disease was high. Besides, among the patients’ relatives, percentage of autoimmnue diseases, especially MS was observed to be high. Psoriasis was among the mostly seen diseases in both groups. MS and rheumatoid arthritis were observed to be the mostly seen autoimmune diseases among relatives.

Özet

AMAÇ: Otoimmün yolaklarla gittiği düşünülen bir hastalık olan Multipl Skleroz (MS) benzer yolakları kullanan otoimmün hastalıklarla birlikte görülebilmektedir. AMAÇ: Bu tanımlayıcı çalışmada Ankara ve Samsun merkezlerinde takip edilen MS hastalarının kendilerinde ve birinci derece yakınlarında görülen otoimmün hastalık ilişkisinin incelenmesi amaçlanmıştır. YÖNTEMLER: Çalışmaya 784 MS hastası dahil edilmiştir. Çalışmada anket uygulaması kullanılmış ve kayıtlı hastaların dosyaları taranmıştır. Düzenlenen ankette, hem hastaların kendilerinde hem de 1. derece yakınlarında, MS hastalarında yüzdesinin arttığı düşünülen 13 spesifik otoimmün hastalık sorgulanmıştır. Veriler dosya taraması ve anket sorgulaması olarak ayrı ayrı değerlendirilmiştir. Elde edilen Ankara ve Samsun merkezi sonuçları karşılaştırılmıştır. BULGULAR: Çalışmada anket kapsamındaki kişilerden Ankara merkezinde 9’unda (%5,3) ek otoimmün hastalık, 26 (%15,3) hastanın akrabasında otoimmün hastalık saptanmıştır; bu veriler Samsun merkezinde sırasıyla 8 (%17,4) ve 21 (%45,7)’dir. Samsun merkezinde hem ek otoimmün hastalık hem de akrabalardaki otoimmün hastalık yüzdesinin daha yüksek olduğu belirlenmiştir. Psöriazis Samsun merkezinde en çok görülen hastalık olup Ankara’da da en çok görülenler arasındadır. Akrabalar arasında en fazla izlenen otoimmün hastalık Ankara merkezinde MS (%5,9), Samsun merkezinde romatoid artrittir (%32,6). Dosya taraması sonuçlarında ise MS hastalarındaki ek otoimmün hastalık yüzdeleri Ankara’da %2,9, Samsun’da %5,2’dir. Ankara merkezinde otoimmün tiroid hastalığı (Graves ve Hashimoto hastalıkları), Samsun merkezinde Behçet hastalığı en çok görülen hastalıktır.Tüm grupta kadın hastalarda (%17,4) ve ailelerindeki otoimmün hastalık yüzdesinin erkek hasta (%5,3) ve akrabalarından yüksek olduğu görülmüştür. SONUÇ: Çalışmada MS hastalarında ek otoimmün hastalık bulunma yüzdesi ile MS hastalarının ailelerinde otoimmün hastalık bulunma yüzdesinin yüksek olduğu görülmüştür. Psöriazis her iki merkezde de en çok görülen hastalıklardandır. Akrabalar arasında ise MS ve romatoid artritin en çok görülen otoimmün hastalık olduğu gözlenmiştir.

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Cite This Article

TERZİ, M., ONAR, M., ERTÜRK, Ö., ACAR, N. P., BADAK, E., TURGUT, S., UYANIK, S., EVRAN, S., İSKENDER, Z., ÇORUM, S., DOĞAN, B. G., KURNE, A., KARABUDAK, R., DEMİRCİ, T., SAVRAN, E. (2022). Evaluating the existence of other autoimmune diseases among multiple sclerosis patients and their first degree relatives. Türk Nöroloji Dergisi, Cilt: 14 - Sayı: 2, 104–110. https://ajindex.com/articles/637047

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