AI Summary & Key Takeaways
AI InsightConclusion: High levels of serum leptin in patients taking VPA and significantly low levels of serum leptin in patients taking VPA and TPM in our study are in agreement with the hypotheses that weight changes induced with VPA and TPM are related to the alterations in serum leptin levels.
📌 3 Key Takeaways
Abstract
Objective: Leptin is considered to be a signal factor that regulates body weight and energy expenditure, and there is a strong correlation between serum leptin concentrations, body mass index (BMI) and body fat mass in humans. Our aim in this study was to evaluate the role of leptin in valproic acid (VPA) and topiramate (TPM) related weight changes in epileptic patients. Patients and Methods: BMI was calculated and serum leptin and insulin levels were measured in 56 patients with epilepsy (40 patients taking VPA and 16 patients taking VPA and TPM) and in 40 healthy control subjects. Results: Obesity was seen in 21 (52.5%) patients in the VPA-treated group, in 15 (37.5%) patients in the control group and in only 1 (6.3%) male in the VPA-TPM-treated group. BMI was lower in the group treated with VPA and TPM (p< 0.001). Serum leptin concentrations were correlated with the BMI (r= 0.49, p< 0.001) and were significantly higher in obese subjects (p< 0.001) and in females (p< 0.001). Serum leptin levels were significantly lower in patients treated with both VPA and TPM (p< 0.05). Conclusion: High levels of serum leptin in patients taking VPA and significantly low levels of serum leptin in patients taking VPA and TPM in our study are in agreement with the hypotheses that weight changes induced with VPA and TPM are related to the alterations in serum leptin levels.
Özet
Amaç: Leptin, vücut ağırlığını ve enerji dengesini düzenleyen bir sinyal molekülüdür. Serum leptin düzeyi, beden kitle indeksi ve vücut yağ oranı ile korelasyon göstermektedir. Bu çalışmada epileptik hastalarda valproik asit (VPA) ve topiramat (TPM) ile ilişkili beden kitle değişikliklerinde leptinin rolü araştırılmıştır. Hastalar ve Yöntem: Elli altı epilepsi hastası (40 VPA kullanan, 16 VPA ve TPM kullanan hasta) ve 40 sağlıklı gönüllüde beden kitle indeksi hesaplanmış ve serum leptin ve insülin düzeyleri ölçülmüştür. Bulgular: Sadece VPA kullanan hastaların 21 (%52.5)’i, kontrol hastalarının 15 (%37.5)’i obez iken, VPA ve TPM’yi birlikte kullanan hastalardan sadece 1 (%6.3)’i obezdir. Beden kitle indeksi VPA ve TPM’yi birlikte kullanan hastalarda daha düşüktür (p< 0.001). Serum leptin düzeyleri, beden kitle indeksi ile korelasyon göstermektedir (r= 0.49, p< 0.001). Serum leptin düzeyleri obezlerde (p< 0.001) ve kadınlarda (p< 0.001) daha yüksek, VPA ve TPM kombinasyonu ile tedavi edilen hastalarda daha düşüktür (p< 0.05). Yorum: Çalışmamızda VPA kullanan hasta grubunda yüksek, VPA ve TPM’yi birlikte kullanan hasta grubunda ise anlamlı düzeyde düşük leptin konsantrasyonlarının bulunmuş olması, VPA ve TPM ile indüklenen beden kitlesi değişikliklerinin serum leptin değişiklik leri ile ilişkili olduğu hipotezini desteklemektedir.