Journals / Türk Nöroloji Dergisi / 2019 / Cilt: 25 - Sayı: 1

Experience of Intravenous Thrombolytic Treatment in Sanliurfa: A Prospective Study

Şanlıurfa’da İntravenöz Trombolitik Tedavi Deneyimi: Prospektif Bir Çalışma

Pages
19–25
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

ITT was given to seven patients aged ≥80 years, five patientswith NIHSS

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Stroke ranks second among the diseases that cause death and third among the causes of disability in Turkey.
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Key Findings & Data:An average of 1.9 million neurons dieevery minute due to acute ischemic stroke and therefore ‘time is brain’.
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Conclusion & Impact:ITT was given to seven patients aged ≥80 years, five patientswith NIHSS
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Stroke ranks second among the diseases that cause death and third among the causes of disability in Turkey. An average of 1.9 million neurons dieevery minute due to acute ischemic stroke and therefore ‘time is brain’. Intravenous thrombolytic treatment (ITT) and, if possible, endovascular treatment shouldbe initiated quickly. We aimed to share our ITT experience in Sanliurfa with this study.Materials and Methods: We recorded the clinical and demographic characteristics, risk factors, and three-month follow-up of 21 patients with acute ischemicstroke who were given ITT between June 2015 and July 2017.Results: Of the 21 patients, nine were male and 12 were female, and the mean age was 72.1±11.8 (range, 48-87) years. Large vessel occlusion was found in five(23.8%) patients, cardioembolism in 9 (42.9%), and small vessel occlusion in 2 (9.5%) patients; etiology was not determined in five (23.8%) patients. Atrialfibrillation was found in 38.1%, hypertension in 57.1%, diabetes mellitus in 23.8%, coronary artery disease in 33.3%, hyperlipidemia in 19%, and smokingin 33.3% of the patients.The NIHSS score was 11.7±6.7 (range, 2-24) prior to treatment. The symptom-onset to needle time was 185±55.8 minutes when 19patients were evaluated. Intracerebral hemorrhage was observed in two (9.5%) patients after treatment. One patient was asymptomatic and the symptomaticpatient (4.75%) died despite decompression surgery. Ten patients died and the mortality rate was 47.6% at the end of the three-month follow-up period. Themodified Rankin scale score was 0-2 in eight patients (38.1%) and was 0-1 in seven patients (33.3%). ITT was given to seven patients aged ≥80 years, five patientswith NIHSS

Özet

Amaç: İnme, Türkiye’de ölüme neden olan hastalıklar içerisinde ikinci sırada ve özürlülüğe yol açan nedenler içerisinde üçüncü sıradadır. Akut iskemik inmeye (Aİİ) bağlı her geçen dakikada ortalama 1,9 milyon nöron ölmektedir ve bu nedenle “zaman beyindir”. Hızlı bir şekilde intravenöz trombolitik tedaviye (İTT) ve mümkünse endovasküler tedaviye başlanmalıdır. Biz bu çalışma ile Şanlıurfa’daki İTT deneyimimizi paylaşmayı amaçladık. Gereç ve Yöntem: Haziran 2015 ve Temmuz 2017 arasında başvuran, Aİİ tanısı konarak İTT verilen 21 hastanın klinik ve demografik özelliklerini, risk faktörlerini ve 3 aylık izlemlerini kaydettik. Bulgular: Çalışmaya dahil edilen 21 hastanın 12’si kadın, 9’u erkekti ve yaş ortalamaları 72,1±11,8 (48-87) idi. Etiyolojik incelemede hastaların beşinde (%23,8) büyük damar hastalığı, dokuzunda (%42,9) kardiyoembolizm, ikisinde (%9,5) küçük damar hastalığı saptanırken, beşinde (23,8%) neden bulunamadı. Hastaların %38,1’inde atrial fibrilasyon, %57,1’inde hipertansiyon, %23,8’inde diabetes mellitus, %33,3’ünde koroner arter hastalığı, %19’unda hiperlipidemi ve %33,3’ünde sigara kullanımı mevcuttu. Hastaların tedavi öncesi National Institutes of Health Stroke Scale (NIHSS) skoru 11,7±6,7 (2-24) idi. Semptom başlangıcından tedaviye başlanana kadar geçen süre 19 hasta değerlendirildiğinde 185±55,8 dakika idi. İki hastada (%9,5) tedavi sonrası intraserebral kanama gözlendi. Birisi asemptomatikti, semptomatik (%4,75) olan bir hasta ise dekompresif cerrahi uygulanmasına rağmen kaybedildi. Üç aylık takipte on hasta kaybedildi ve mortalite oranı (%47,6) olarak hesaplandı. Üçüncü ay modifiye Rankin skalası skoru, sekiz hastada (%38,1) 0-2, yedi hastada (%33,3) 0-1 idi. Yedi hastada ≥80 yaş, beş hastada NIHSS

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Cite This Article

ÖNALAN, A., ATMACA, M. Ç., KÖYLÜOĞLU, A. C., BALDUZ, M., ATMACA, M. M., MARUFOĞLU, F., KARGI, E., KOCATÜRK, Ö. (2022). Experience of Intravenous Thrombolytic Treatment in Sanliurfa: A Prospective Study. Türk Nöroloji Dergisi, Cilt: 25 - Sayı: 1, 19–25. https://ajindex.com/articles/636694

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