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Journals / Türk Nöroloji Dergisi / 2021 / Cilt: 27 - Sayı: 1

Fetal Outcomes of Anti-epileptic Drug Use in Pregnancy: Teratologic Approach

Gebelikte Anti-epileptik İlaç Kullanımının Fetal Sonuçları: Teratolojik Yaklaşım

Aysel KALAYCI YİĞİN
Mustafa Tarık ALAY
Mehmet SEVEN
Pages
27–33
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: The difference between the prevalence of major, minor anomalies, and behavioral defects between pregnant women using VPA and the control group was statistically significant (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: To examine the fetal effects of valproic acid (VPA) and carbamazepine (CBZ) used as monotherapy during pregnancy, to determine the anomalies, and to compare them with a control group and previous literature.
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Key Findings & Data:Materials and Methods: The data of 10,562 pregnant women who presented to our outpatient clinic between 2009 and 2018 for teratologic consultation were reviewed retrospectively.
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Conclusion & Impact:Results: The difference between the prevalence of major, minor anomalies, and behavioral defects between pregnant women using VPA and the control group was statistically significant (p
🔬Design:Review & Systematic Survey
📍Scope:2009 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: To examine the fetal effects of valproic acid (VPA) and carbamazepine (CBZ) used as monotherapy during pregnancy, to determine the anomalies, and to compare them with a control group and previous literature. Materials and Methods: The data of 10,562 pregnant women who presented to our outpatient clinic between 2009 and 2018 for teratologic consultation were reviewed retrospectively. The study group consisted of 95 pregnant women (VPA: n=49, CBZ: n=46) who were followed up with the diagnosis of epilepsy and who used VPA or CBZ only as monotherapy during pregnancy. The control group was composed of 88 pregnant women in the same age group, who had no chronic disease, were not expected to cause an increased risk in the first trimester, and used short-term risk group B drugs due to different health problems. Results: The difference between the prevalence of major, minor anomalies, and behavioral defects between pregnant women using VPA and the control group was statistically significant (p

Özet

Amaç: Bu çalışmada, valproik asit (VPA) veya karbamazepini (CBZ) monoterapi şeklinde kullanan gebelerde bu ilaçların fetal etkilerinin teratolojik bakış açısıyla incelenmesi, bebeklerde meydana gelen anomalilerin tespit edilmesi ve bulguların kontrol grubuyla ve önceki literatür verileriyle karşılaştırılması hedeflenmiştir. Gereç ve Yöntem: Polikliniğimize teratolojik danışma amacıyla 2009-2018 yılları arasında başvuran ve teratolojik danışma raporu düzenlenmiş olan 10.562 gebenin dosyaları retrospektif olarak incelendi. Çalışma grubu, epilepsi tanısıyla izlenen ve gebelik döneminde sadece monoterapi şeklinde VPA veya CBZ kullanan 95 gebeden (VPA: 49, CBZ: 46) oluşturuldu. Kontrol grubu, benzer yaş grubunda olup, herhangi bir kronik hastalığı bulunmayan, değişik sağlık sorunları nedeniyle ilk trimesterde risk artışına yol açması beklenmeyen kısa süreli B risk grubu ilaç kullanan 88 gebeden oluşturuldu. Bulgular: VPA kullanan gebeler ile kontrol grubu arasında majör-minör anomali ve davranış kusuru görülme sıklığı açısından istatistiksel olarak anlamlı fark saptandı (sırasıyla; p

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Cite This Article

YİĞİN, A. K., ALAY, M. T., SEVEN, M. (2022). Fetal Outcomes of Anti-epileptic Drug Use in Pregnancy: Teratologic Approach. Türk Nöroloji Dergisi, Cilt: 27 - Sayı: 1, 27–33. https://ajindex.com/articles/636551

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