Journals / Türk Nöroloji Dergisi / 2021 / Cilt: 27 - Sayı: 2

The Predictive Value of the Systemic Immune-inflammation Index as a New Prognostic Marker for Disability in Patients with Multiple Sclerosis

MS Hastalarında Engellilik İçin Yeni Bir Prognostik Belirteç Olarak Sistemik İmmün-enflamasyon İndeksinin Prediktif Değeri

Pages
133–139
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

All values obtained through complete blood counts were significantly lower in the patient group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Multiple sclerosis (MS) is a condition involving central nervous system invasion by immune-inflammatory cells.
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Key Findings & Data:Materials and Methods: We retrospectively reviewed the medical records of 148 patients with MS and 84 healthy controls and gathered the relevant clinicallaboratory data.
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Conclusion & Impact:All values obtained through complete blood counts were significantly lower in the patient group (p
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Multiple sclerosis (MS) is a condition involving central nervous system invasion by immune-inflammatory cells. In this study, we investigated whether the systemic immune-inflammation index (SII) could predict disability cross-sectionally as a novel and useful tool in patients with MS. Materials and Methods: We retrospectively reviewed the medical records of 148 patients with MS and 84 healthy controls and gathered the relevant clinicallaboratory data. SII in the remission period was calculated using the equation (SII: Platelet count x neutrophil count/lymphocyte count). The odds ratio of each immune formulation index was calculated by logistic regression analysis. In addition, the cut-off value, sensitivity and specificity of SII were calculated using receiver operating characteristics curve analysis. Results: Age and sex characteristics were similar in the groups (p>0.05). All values obtained through complete blood counts were significantly lower in the patient group (p

Özet

Amaç: Multipl skleroz (MS) hastalığı doğuştan gelen ve kazanılmış immün sistem disfonksiyonunun özürlülük artışına yol açtığı santral sinir sistemi istilası durumudur. Biz bu çalışmada, MS hastalarında yeni ve kullanışlı bir araç olarak sistemik immün-enflamasyon indeksinin (SII) kesitsel olarak disabiliteyi tahmin edip edemeyeceğini araştırdık. Gereç ve Yöntem: Yüz kırk sekiz MS hastasının tıbbi kayıtlarını retrospektif olarak inceledik ve klinik-laboratuvar verilerini elde ettik. Atak dışı dönemdeki SII, (SII: Trombosit sayısı x nötrofil sayısı/lenfosit sayısı) denklemi ile hesaplandı. Elde edilen hemogram parametreleri sağlıklı kontrol grubu ile karşılaştırıldı. Expanded Disability Status scale (EDSS) >3 ve EDSS 0,05). Hasta grubunda trombosit, nötrofil ve monositin lenfosite oranlanması ile edilen tüm değerler anlamlı düşüktü (p

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Cite This Article

TANIK, N., AKTÜRK, T., SAÇMACI, H. (2022). The Predictive Value of the Systemic Immune-inflammation Index as a New Prognostic Marker for Disability in Patients with Multiple Sclerosis. Türk Nöroloji Dergisi, Cilt: 27 - Sayı: 2, 133–139. https://ajindex.com/articles/636523

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