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Journals / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi / 2010 / Cilt: 19 - Sayı: 2

Effect of atorvastatin therapy on IL-6, IL-10, TNF-α and TGF-β in chronic hemodialysis patients

Kronik hemodiyaliz hastalarında atorvastatin tedavisinin IL-6, IL-10, TNF-α ve TGF-β üzerine etkilerinin araştırılması

Can SEVİNÇ
Gülbu IŞITMANGİL
Ali ÖZDEMİR
İbrahim BERBER
Emre ERİŞKON
İ Funda TÜRKMEN
Serdar DEMİRAL
Pages
88–93
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Suppression of TNF-α, an important proinflammatory cytokine, is a valuable result to emphasize the anti-inflammatory effect of atorvastatin.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: We aimed to compare serum cytokine levels of IL- 6, IL-10, TNF-α and TGF-β before and after atorvastatin therapy in chronic hemodialysis (HD) patients in order to detect inflammatory and anti-inflammatory effects of atorvastatin in this study.MATERIAL and METHODS: Thirty-one patients (19 male, 12 female) undergoing continuous hemodialysis with a mean age 48.5+12.8 and dialysis age 12+4.3 years were included in our study.
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Key Findings & Data:HD was planned as 3 days a week with Fresenius 4008-B during 4 hours, FX80 with Kt/V >1.4.
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Conclusion & Impact:Suppression of TNF-α, an important proinflammatory cytokine, is a valuable result to emphasize the anti-inflammatory effect of atorvastatin.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: We aimed to compare serum cytokine levels of IL- 6, IL-10, TNF-α and TGF-β before and after atorvastatin therapy in chronic hemodialysis (HD) patients in order to detect inflammatory and anti-inflammatory effects of atorvastatin in this study.MATERIAL and METHODS: Thirty-one patients (19 male, 12 female) undergoing continuous hemodialysis with a mean age 48.5+12.8 and dialysis age 12+4.3 years were included in our study. HD was planned as 3 days a week with Fresenius 4008-B during 4 hours, FX80 with Kt/V >1.4. We measured the serum cytokine levels of the patients with the ELISA technique, before atorvastatin therapy and after 40 mg/day atorvastatin administration during 8 weeks.RESULTS: Hemodialysis leads to a statistically significant increase in proinflammatory cytokines (IL- 6 and TNF-α) and antiinflammatory cytokines (IL-10 ve TGF-β). However, atorvastatin therapy acts to increase IL-6 and IL-10 only due to hemodialysis.CONCLUSION: Atorvastatin therapy suppressed the increase in TNF-α and TGF-β due to hemodialysis. Suppression of TNF-α, an important proinflammatory cytokine, is a valuable result to emphasize the anti-inflammatory effect of atorvastatin.

Özet

AMAÇ: Bu çalışmanın amacı, atorvastatinin pro- ve anti-inflamatuar sistem üzerine etkisini kronik hemodiyaliz (HD) hastalarında immünolojik açıdan değerlendirmekti.GEREÇ ve YÖNTEM: Çalışmamıza düzenli HD tedavisi altındaki yaş ortalaması 48,5 ± 12,8 ve diyaliz yaşı 12,0 ± 4,3 yıl olan 31 hasta (19 erkek, 12 kadın) alındı. Haftada 3 gün Fresenius 4008-B ile 4 saat hemodiyaliz tedavisi, Fx80 ile Kt/V >1.4 olacak şekilde planlandı. Prediyaliz ve postdiyaliz hasta serumlarında IL-6, IL-10, TNF-α, TGF-β sitokin düzeyleri atorvastatin tedavisinden önce ve 8 hafta 40 mg/gün tedavi aldıktan sonra ELISA yöntemi ile çalışıldı.BULGULAR: HD girişte ve çıkışta; atorvastatin öncesi ile atorvastatin sonrası IL-6 ve IL-10 ölçümleri arasındaki fark istatistiksel olarak anlamlı bulunmamıştır (p>0,05). Hemodiyalize girişte; atorvastatin öncesi TNF-α ve TGF-β düzeyleri sonrasına göre istatistiksel olarak anlamlı düzeyde artış göstermektedir (p

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Cite This Article

SEVİNÇ, C., IŞITMANGİL, G., ÖZDEMİR, A., BERBER, İ., ERİŞKON, E., TÜRKMEN, İ. F., DEMİRAL, S. (2022). Effect of atorvastatin therapy on IL-6, IL-10, TNF-α and TGF-β in chronic hemodialysis patients. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 19 - Sayı: 2, 88–93. https://ajindex.com/articles/636497

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