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Journals / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi / 2010 / Cilt: 19 - Sayı: 3

The relationship between endothelial dysfunction and pentraxin-3 concentration in chronic kidney disease

Kronik böbrek hastalarında endotel işlev bozukluğu ve serum pentraxin-3 düzeyleri

Murat KARAMAN
Fatih BULUCU
Mutlu SAĞLAM
Mahmut İlker YILMAZ
Elvan ŞAHİN
Seyit Ahmet AY
Erdinç ÇAKIR
Pages
192–198
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Plasma PTX-3 levels of the stage 1-2-3 CKD group were similar to those of the controls, while other groups had significantly higher values (p

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: Cardiovascular diseases are the leading cause of morbidity and mortality in chronic kidney disease (CKD).
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Key Findings & Data:Pentraxin-3 (PTX-3), a new candidate marker for inflammation is expressed in a variety of cell types.
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Conclusion & Impact:Plasma PTX-3 levels of the stage 1-2-3 CKD group were similar to those of the controls, while other groups had significantly higher values (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

AIM: Cardiovascular diseases are the leading cause of morbidity and mortality in chronic kidney disease (CKD). Inflammation and endothelial dysfunction contribute to the development of cardiovascular disease in CKD. Pentraxin-3 (PTX-3), a new candidate marker for inflammation is expressed in a variety of cell types. We aimed to investigate the relation between plasma PTX-3, serum hs-CRP levels and endothelial dysfunction in CKD.MATERIAL and METHODS: One hundred and twenty-five patients with CKD were studied. Patients were divided into 5 groups according to their glomerular filtration rate (GFR) as assessed by K/DOQI guidelines. Twenty-five healthy subjects were studied as controls. Venous samples were obtained from all subjects for PTX-3 and hs-CRP levels in addition to detailed metabolic panel. Endothelial dysfunction was assessed from all subjects by flow-mediated dilatation (FMD).RESULTS: FMD levels were significantly decreased in all stages with the higher the stage of CKD, the lower the levels of FMD. Plasma PTX-3 levels of the stage 1-2-3 CKD group were similar to those of the controls, while other groups had significantly higher values (p

Özet

AMAÇ: Kronik böbrek hastalığında (KBH) morbidite ve mortalitenin en önemli nedenini kardiyovasküler hastalıklar oluşturmaktadır. Endotel işlev bozukluğu ve enflamasyon KBH'da kardiyovasküler hastalık gelişimine katkıda bulunur. Enflamasyon belirteci olmaya aday yeni bir belirteç olan Pentraxin-3 (PTX- 3) birçok farklı hücreden salınmaktadır. Amacımız KBH olanlarda endotel işlev bozukluğu ile plazma PTX-3, serum hs-CRP düzeyleri arasındaki ilişkiyi araştırmaktır.GEREÇ ve YÖNTEMLER: KBH olan 125 hasta çalışmaya alındı. Hastalar K/DQOI kılavuzunda belirlenen glomerüler filtrasyon hızına (GFH) göre 5 gruba ayrıldı. Kontrol olarak 25 sağlıklı kişi çalışıldı. Çalışmaya alınan tüm kişilerden venöz kan örneği alındı, detaylı metabolik panele ek olarak plazma PTX-3 ve serum hs-CRP düzeyleri ölçüldü. Endotel işlev bozukluğu çalışmaya katılan tüm kişilerden elde edilen endotel bağımlı vazodilatasyon (EBVD) değeri ile değerlendirildi.BULGULAR: EBVD düzeyleri bütün evrelerde belirgin olarak azalmaktaydı. KBH evresi ilerledikçe EBVD değeri de paralel olarak o kadar azalmaktaydı. Plazma PTX-3 düzeyi evre 1-2-3 hastalarda kontrollerden farksız iken diğer gruplarda belirgin olarak daha yüksek saptandı. Ek olarak hsCRP düzeyleri KBH'nın tüm evrelerinde belirgin olarak artmaktaydı. EBVD ve GFH arasında belirgin pozitif bir korelasyon saptandı (r=0,762, p

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Cite This Article

KARAMAN, M., BULUCU, F., SAĞLAM, M., YILMAZ, M. İ., ŞAHİN, E., AY, S. A., ÇAKIR, E. (2022). The relationship between endothelial dysfunction and pentraxin-3 concentration in chronic kidney disease. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 19 - Sayı: 3, 192–198. https://ajindex.com/articles/636488

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