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Journals / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi / 2010 / Cilt: 19 - Sayı: 3

Effect of spironolactone on diastolic heart function in patients with chronic kidney disease

Kronik böbrek hastalığı olan hastalarda spironolaktonun diastolik kalp fonksiyonlarına etkisi

Tayfun ŞAHİN
Erkan ŞENGÜL
Çiğdem ÇAĞLAYAN
Ahmet YILMAZ
Pages
186–191
Publication Date
2022-11-05
DOI
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The statistical analysis was performed using SPSS version 13.0.RESULTS: There were significant differences between pretreatment and posttreatment lateral deceleration time, right ventricular deceleration time, and anterior late diastolic velocity (P=0.010, P

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Objective & Hypothesis:PURPOSE: The aim of this study was to evaluate the effect of spironolactone on diastolic heart functions in patients with chronic kidney disease by tissue Doppler echocardiography.MATERIAL and METHODS: Twenty-four patients (11 males, 13 females) were included to the study.
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Key Findings & Data:The etiology of chronic kidney disease was diabetes mellitus in 14 patients (58%).
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Conclusion & Impact:The statistical analysis was performed using SPSS version 13.0.RESULTS: There were significant differences between pretreatment and posttreatment lateral deceleration time, right ventricular deceleration time, and anterior late diastolic velocity (P=0.010, P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

PURPOSE: The aim of this study was to evaluate the effect of spironolactone on diastolic heart functions in patients with chronic kidney disease by tissue Doppler echocardiography.MATERIAL and METHODS: Twenty-four patients (11 males, 13 females) were included to the study. The etiology of chronic kidney disease was diabetes mellitus in 14 patients (58%). Biochemical and 24-hour proteinuria analysis, blood pressure measurements, and tissue Doppler echocardiography examination were obtained before the therapy. Spironolactone (25 mg/d) was then added to the treatment. The serum potassium level was measured at the first and fourth weeks. After a period for eight weeks, all the analyses were repeated. The statistical analysis was performed using SPSS version 13.0.RESULTS: There were significant differences between pretreatment and posttreatment lateral deceleration time, right ventricular deceleration time, and anterior late diastolic velocity (P=0.010, P

Özet

AMAÇ: Bu çalışmanın amacı, kronik böbrek hastalığı olan hastalarda spironolaktonun diastolik kalp fonksiyonları üzerindeki etkisini doku Doppler ekokardiyografi ile incelemektir.GEREÇ ve YÖNTEMLER: Bu çalışmaya 24 hasta (11 E, 13 K) alındı. Kronik böbrek hastalığı etiyolojisi 14 hastada (%58) diabetes mellitus idi. Tedavi öncesi biyokimya ve 24 saatlik idrarda proteinüri analizleri, kan basıncı ölçümü ve doku Doppler ekokardiyografi incelemesi yapıldı. Daha sonra tedaviye 25 mg/gün spironolakton ilave edildi. Serum potasyum düzeyi 1. ve 4. haftada kontrol edildi. Sekiz haftalık tedavi sonrasında tüm analizler tekrarlandı. İstatistiksel analizler SPSS ver. 13 ile gerçekleştirildi.BULGULAR: Doku Doppler ekokardiyografi ile tedavi öncesi ve tedavi sonrası lateral deselerasyon zamanı, sağ ventrikül deselerasyon zamanı ve anterior Am değerleri arasında istatistiksel olarak anlamlı farklılıklar bulundu (sırasıyla, P=0,010, P

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Cite This Article

ŞAHİN, T., ŞENGÜL, E., ÇAĞLAYAN, Ç., YILMAZ, A. (2022). Effect of spironolactone on diastolic heart function in patients with chronic kidney disease. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 19 - Sayı: 3, 186–191. https://ajindex.com/articles/636468

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