Journals / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi / 2015 / Cilt: 24 - Sayı: 1

Meyan kökü; Rabdomyoliz ve akut böbrek yetmezliğinin beklenmeyen bir nedeni

Licorice ıngestion; An unusual cause of rhabdomyolysis and acute renal failure

Pages
106–109
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Furthermore, we want to drawattention to the importance of a detailed medical history, including the use of herbal medications andregional traditional characteristics to confrm the diagnosis.

📌 3 Key Takeaways

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Objective & Hypothesis:Licorice root has glycyrrhizic acid as the active ingredient and is responsible for a primaryhyperaldosteronism-like syndrome with hypokalemia, metabolic alkalosis, and hypertension, typicallyaccompanying low aldosterone.
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Key Findings & Data:Herein, we present a rare complication of licorice consumption withacute renal failure.A 49-year-old male patient was admitted to emergency department with generalized muscle pain/weakness, nausea, and dark urine.
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Conclusion & Impact:Furthermore, we want to drawattention to the importance of a detailed medical history, including the use of herbal medications andregional traditional characteristics to confrm the diagnosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Licorice root has glycyrrhizic acid as the active ingredient and is responsible for a primaryhyperaldosteronism-like syndrome with hypokalemia, metabolic alkalosis, and hypertension, typicallyaccompanying low aldosterone. Herein, we present a rare complication of licorice consumption withacute renal failure.A 49-year-old male patient was admitted to emergency department with generalized muscle pain/weakness, nausea, and dark urine. He was suffering from confusion and somnolence and the generalcondition was moderate. At laboratory assessment, potassium was 2.3 mEq/L, sodium 141 mEq/L, urea146 mg/dl , creatinine 6.24 mg/dl, and total creatine kinase 4597 U/L. He had metabolic alkalosis (pH7.59, HCO 3- 37.2 mmol/L). Hemodialysis was performed because of uremic neurological symptoms.His detailed anamnesis revealed consumption of herbal medication for the last 1.5 years to treat gastriccomplaints. The herbal medication included 16 gr licorice root powder (~600-750 mg glycyrrhizic acid)per 100 gr. The plasma aldosterone concentration was signifcantly suppressed [1.6 pg/ml (normal;38.1-300 pg/mL)]. Under these conditions, our fnal diagnosis was hypokalemic rhabdomyolysis andacute renal failure due to licorice ingestion.We present a rare life-threating effect of licorice ingestion in this report. Furthermore, we want to drawattention to the importance of a detailed medical history, including the use of herbal medications andregional traditional characteristics to confrm the diagnosis.

Özet

Meyankökü;GüneydoğuAnadoludagelenekselbiriçecekolmasınınyanısıragıda/bitkiselilaçendüstrisindekullanılır.Aktifmaddesigliserizikasittir,primerhiperaldestronizimbenzeritabloilehipokalemi,metabolikalkalozvehipertansiyonanedenolabilir.Buolgusunumundameyankökünebağlıgelişen,literatürdenadirolan,birrabdomiyolizveakutböbrekyetmezliğiolgususunulmuştur.49yaşındaerkek;kasgüçsüzlüğü/ağrısı,bulantı,idrardakoyulaşmayakınmalarıileacilservisebaşvurdu.Fizikmuayenesindebilinçbulanıklığıveuykuyameyilvardı.Hastanınlaboratuvarbulguları;potasyum2,3mEq/L,sodyum141mEq/L,üre146mg/dl,kreatin6,24mg/dl,totalkreatinkinaz4597U/Lidi,ayrıcametabolikalkalozu(pH7,59,HCO 3- 37.2mmol/L)mevcuttu.Hastaüremiknörolojikbulgularınedeniylehemodiyalizealındı.Bilinçdurumudüzelincealınandetaylıanamnezdeyaklaşık1,5yıldırmideyakınmasınedeniylebitkiselilaçlarkullandığıvebitkiselilacın100grnın16grmeyankökü(~600-750mggliserizikasit)içerdiğiöğrenildi.Bubulgularışığındakesintanımız;meyanköküalımınabağlıhipokalemi,rabdomiyolizveakutböbrekyetmezliğioldu.Hastanınplazmaaldosterondüzeylerindekibaskılanmadatanımızıdesteklernitelikteydi[1,6pg/ml(normal;38,1-300pg/ml)].Bitkiselilaçlarvegıdaendüstrisindeyaygınolarakkullanılanmeyanköküyaşamıtehditedicidüzeydeakutböbrekyetmezliğinenedenolabilir.Ayrıcabuolgudoğrultusundahekimlere,bitkiselilaçlarveyöreselgelenekleriiçerendetaylıanamnezalınmasının,tanıdakiönemininvurgulanmasıamaçlanmıştır.

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Cite This Article

YILMAZER, B., RUHİ, Ç., DANIŞ, R., BERKETOĞLU, N., KAYA, A. V., KAYA, S. (2022). Meyan kökü; Rabdomyoliz ve akut böbrek yetmezliğinin beklenmeyen bir nedeni. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 24 - Sayı: 1, 106–109. https://ajindex.com/articles/636247

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References (1)

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