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Journals / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi / 2015 / Cilt: 24 - Sayı: 1

Önemli bir problem: Transplantasyon sonrası fokal segmental glomeruloskleroz nüksü ve plazmaferez

An İmportant problem: Posttransplant focal segmental glomerulosclerosis recurrence and plasmapheresis

Rümeyza KAZANCIOĞLU
Serdar KAHVECİOĞLU
Hüseyin DOĞAN
Aydın TÜRKMEN
Türker EMRE
Yaşar Kerem ÇAlIŞKAN
Pages
47–54
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

ReSulTS: The recurrence rate was signifcantly higher in FSGS group than controls (55 % vs 0%, p

📌 3 Key Takeaways

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Objective & Hypothesis:OBJecTIve: Focal segmental glomerulosclerosis (FSGS) as a primary glomerular disease arerefractory to therapy and progress to End stage renal disease. (ESRD).
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Key Findings & Data:In this study, We investigated FSGS recurrence.MATeRIAl and MeTHODS: The graft and patient s survivals, complications, recurrence rates, andtherapeutic approach were documented.
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Conclusion & Impact:ReSulTS: The recurrence rate was signifcantly higher in FSGS group than controls (55 % vs 0%, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJecTIve: Focal segmental glomerulosclerosis (FSGS) as a primary glomerular disease arerefractory to therapy and progress to End stage renal disease. (ESRD). After transplantation, the majorproblems are recurrence of the disease and its treatment. In this study, We investigated FSGS recurrence.MATeRIAl and MeTHODS: The graft and patient s survivals, complications, recurrence rates, andtherapeutic approach were documented. Twenty patients with FSGS and 20 patients as controls wereincluded in the study. ReSulTS: The recurrence rate was signifcantly higher in FSGS group than controls (55 % vs 0%, p

Özet

AMAÇ: Fokalsegmentalglomeruloskleroz(FSGS),primerglomerülhastalığıolaraktedaviyedirençlidirvesondönemböbrekyetersizliğine(SDBY)ilerler.Transplantasyondansonramajörproblemhastalığınnüksetmesiveonuntedavisidir.BuçalışmadaFSGSnüksünüaraştırdık.GeReÇ ve YÖnTeMleR: Greftvehastasürvileri,komplikasyonlar,nüksoranlarıvetedaviyaklaşımlarıdökümenteedildi.FSGSli20hastavekontrololarakdaFSGSdışıglomerülonefritli20hastaçalışmayadahiledildi.BulGulAR: Nüksoranı,FSGSligrupta,FSGSdışıgrubagöreanlamlıolarakyüksekbulundu.(%55ekarşın%0,p=0,0001).FSGSlihastalardacanlıvekadavranakillerinde,sürvioranlarınıbirbirinebenzerbulduk.Greftsürvisiniençoketkileyenfaktörlerdenbirinin,alıcıvevericiarasındakigenetikbenzerlikolduğunusaptadık.Transplantasyonöncesiplasmafereztedavisinin,FSGSnüksünüönlemekaçısındanetkinbirtedaviolduğunutesbitettik.Transplantasyonöncesiplasmaferezuygulanangruptaproteinürioranı%38olaraksaptanırken,plasmaferezuygulanmayangruptabuoran%85olarakbulundu.(p=0,05).SOnuÇ: Sonuçolarakbizimbuçalışmadakienönemliçıkarımlarımız;genetikyakınlığınönemliolması,canlıvekadavranakillerindegreftsürvilerininbenzerbulunması,nükshastalığınıntedavisindeplasmaferezinetkinbirtedaviyöntemiolaraksaptanmışolmasıdır.Ayrıca,dahadaönemlisi,nükshastalığınınönlenmesinde,preemptifplasmaferezi,enetkintedaviyaklaşımıolaraksaptadık.

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Cite This Article

KAZANCIOĞLU, R., KAHVECİOĞLU, S., DOĞAN, H., TÜRKMEN, A., EMRE, T., ÇAlIŞKAN, Y. K. (2022). Önemli bir problem: Transplantasyon sonrası fokal segmental glomeruloskleroz nüksü ve plazmaferez. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 24 - Sayı: 1, 47–54. https://ajindex.com/articles/636229

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