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Journals / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi / 2017 / Cilt: 26 - Sayı: 1

Association Between New Cardiac Biomarkers and Cardiovascular Abnormalities in Asymptomatic Hemodialysis Patients

Asemptomatik Hemodiyaliz Hastalarında Kardiyovasküler Biyobelirteçler ve Kardiyovasküler Anormallikler Arasındaki İlişki

Kenan TURGUTALP
Arzu KANIK
Türkay ÖZCAN
Ahmet KIYKIM
Serap DEMİR
Sibel SARI
Simge BARDAK
Mehmet HOROZ
Ebru GÖK GÖK OĞUZ
Pages
60–66
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

NT-proBNP was negatively correlated with C-reactive protein (r=-41, p

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: Cardiovascular diseases are prevalent in asymptomatic chronic hemodialysis patients.
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Key Findings & Data:MATERIAL and METHODS: A total of 60 hemodialysis patients who were asymptomatic for cardiovascular diseases and 62 age- and sex-matched healthy subjects were enrolled.
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Conclusion & Impact:NT-proBNP was negatively correlated with C-reactive protein (r=-41, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: Cardiovascular diseases are prevalent in asymptomatic chronic hemodialysis patients. New cardiac biomarkers are required for early diagnosis of cardiovascular diseases. In our study, we aimed to investigate associations of troponin-T (Tn-T), heart type fatty acid binding protein (H-FABP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels with clinical, echocardiographic and laboratory parameters of asymptomatic hemodialysis patients. MATERIAL and METHODS: A total of 60 hemodialysis patients who were asymptomatic for cardiovascular diseases and 62 age- and sex-matched healthy subjects were enrolled. Demographic features were recorded, and Tn-T, H-FABP, and NT-proBNP were measured. Clinical, biochemical and echocardiographic evaluations were performed.RESULTS: Tn-T, H-FABP, NT-proBNP levels were significantly higher in hemodialysis patients (p0.05). However, NT-proBNP level >12914 pg/mL was associated with left ventricular hypertrophy. H-FABP was higher in the presence of pulmonary hypertension and tricuspid regurgitation (p=0.025). NT-proBNP was negatively correlated with C-reactive protein (r=-41, p

Özet

AMAÇ: Asemptomatik kronik hemodiyaliz hastalarında kardiyovasküler hastalıklar sık izlemektedir. Kardiyovasküler hastalıkların tanısı için yeni kardiyak biyomarkerlere ihtiyaç vardır. Çalışmamızda, asemptomatik hemodiyaliz hastalarında troponin-T (Tn-T), kalp tipi yağ asit bağlayıcı protein (H-FABP) ve N-terminal pro-brain natriuretik peptid (NT-proBNP) ile klinik, ekokardiyografik ve laboratuvar parametreleri ile ilişkileri araştırıldı. GEREÇ ve yÖNTEMLER: Kardiyovasküler hastalıklar için asemptomatik olan toplam 60 hemodiyaliz hastası ve yaş ve cinsiyet açısından benzer 62 sağlıklı kontrol grubu çalışmaya alındı. Demografik özellikler kaydedildi ve Tn-T, H-FABP ve NT-proBNP ölçüldü. Klinik, biyokimyasal ve ekokardiyografik değerlendirme yapıldı. BULGULAR: Tn-T, H-FABP, NT-proBNP düzeyleri hemodiyaliz hastalarında belirgin olarak daha yüksekti. Kardiyak biyomarkerler ve sol ventikül hipertrofisi veya ejeksiyon fraksiyonu arasında ilişki saptanmadı (p>0.05). Ancak, >12914 pg/ml üzerindeki NT-proBNP düzeyi ile sol ventrikül hipertrofisi ilişkili bulundu. H-FABP, pulmoner hipertansiyon ve triküspit yetmezliğinde daha yüksekti (p=0.025). NT-proBNP, C reaktif protein (r=-41, p

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Cite This Article

TURGUTALP, K., KANIK, A., ÖZCAN, T., KIYKIM, A., DEMİR, S., SARI, S., BARDAK, S., HOROZ, M., OĞUZ, E. G. G. (2022). Association Between New Cardiac Biomarkers and Cardiovascular Abnormalities in Asymptomatic Hemodialysis Patients. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 26 - Sayı: 1, 60–66. https://ajindex.com/articles/636094

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