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Journals / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi / 2018 / Cilt: 27 - Sayı: 3

Peritoneal Fluid Trefoil Factor-3 Peptide Levels and Associated Factors in Chronic Peritoneal Dialysis Patients

Periton Diyalizi Hastalarının Periton Sıvısında Trefoil Faktör 3 Peptid Düzeyleri ve İlişkili Faktörler

Mehmet KOÇ
Ertuğrul ERKEN
Gökmen AKTAŞ
Ebru AŞICIOĞLU
Hakkı ARIKAN
Çetin ÖZENER
Pages
288–292
Publication Date
2022-11-04
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There was a positive correlation between effluent TFF3 levels and PD vintage (r=0.349, p

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: TFF3 is a small peptide hormone secreted from mucous producing cells and many epithelial cells.
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Key Findings & Data:TFF3 inhibits apoptosis, promotes migration and facilitates restoration against injury.
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Conclusion & Impact:There was a positive correlation between effluent TFF3 levels and PD vintage (r=0.349, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: TFF3 is a small peptide hormone secreted from mucous producing cells and many epithelial cells. TFF3 inhibits apoptosis, promotes migration and facilitates restoration against injury. In our cross-sectional study, TFF3 levels in peritoneal fluids of peritoneal dialysis (PD) patients were measured and associated factors were investigated. MATERIAL and METHODS: Peritoneal fluid after a 12-hour dwell and concurrent serum samples of 48 chronic PD patients were collected. Serum and peritoneal fluid TFF3 levels were measured by ELISA. The SPSS15.0 package was used for statistical analysis of database files. RESULTS: The study included 48 patients (men/women; 24/24, mean age: 51.6∓13.9 years) with a median PD vintage of 43 months (3-200). Median effluent TFF3 level was 17.07 ng/ml (2.38-99.4). There was no relationship between the number of peritonitis episodes and TFF3 levels. There was a positive correlation between effluent TFF3 levels and PD vintage (r=0.349, p

Özet

AMAÇ: Trefoil-faktör3 (TFF3) memelilerin mukus üreten hücreleri ve çeşitli epitel hücrelerindensalgılanan küçük bir peptid hormondur. Epitel hücrelerinin apoptozunu engellediği, migrasyonuartırdığı ve hasara karşı koruyucuğa katkı yaptığı bilinmektedir. Kesitsel çalışmamızda periton sıvısıTFF3 düzeyleri belirlenmiş ve ilişkili faktörler araştırılmıştır.GEREÇ ve YÖNTEMLER: Kronik periton diyalizi (PD) nedeniyle takip edilen 48 hastanın 12 saatlikdeğişim sonrası periton sıvısı örnekleriyle, eş zamanlı kan örnekleri toplanmıştır. Periton sıvısı ve serumTFF3 değerleri ELİZA yöntemiyle ölçülmüştür. İstatistiksel değerlendirmede SPSS15.0 programı ilehastaların dosya verileri kullanılmıştır.BULGULAR: Çalışmamızdaki 48 hastanın (erkek/kadın; 24/24, ortalama yaş: 51.6∓13.9 yıl), medyantedavi süresi 43 ay (3-200), periton sıvısı TFF3 düzeyleri medyan 17.07 ng/ml (2.38-99.4) bulundu.Peritonit sıklığı ile TFF3 arasında ilişki bulunamadı. Hastaların tedavi süresi ile periton sıvısı TFF3düzeyleri arasında pozitif korelasyon saptandı (r=0.349, p

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Cite This Article

KOÇ, M., ERKEN, E., AKTAŞ, G., AŞICIOĞLU, E., ARIKAN, H., ÖZENER, Ç. (2022). Peritoneal Fluid Trefoil Factor-3 Peptide Levels and Associated Factors in Chronic Peritoneal Dialysis Patients. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 27 - Sayı: 3, 288–292. https://ajindex.com/articles/636060

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