Journals / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi / 2018 / Cilt: 27 - Sayı: 2

The Association Between Serum Uric Acid and 25-Hydroxyvitamin D in Peritoneal Dialysis Patients

Periton Diyaliz Hastalarında Serum Ürik Asit ve 25-Hidroksivitamin D Seviyesi Arasındaki İlişki

Pages
162–165
Publication Date
2022-11-04
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Prospective studies involving more patients are needed in PD patients to prove a relationship between these two serum markers.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:OBJECTIVE: In peritoneal dialysis (PD) patients, a low level of serum 25-hydroxyvitamin D is associated with an increased risk of cardiovascular events.
📊
Key Findings & Data:Hyperuricemia is also associated with an increased mortality rate in chronic kidney disease patients.
💡
Conclusion & Impact:Prospective studies involving more patients are needed in PD patients to prove a relationship between these two serum markers.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: In peritoneal dialysis (PD) patients, a low level of serum 25-hydroxyvitamin D is associated with an increased risk of cardiovascular events. Hyperuricemia is also associated with an increased mortality rate in chronic kidney disease patients. The aim of our study was to determine whether there was a relationship between serum uric acid and 25-hydroxyvitamin D in PD patients. MATERIAL and METHODS: A total of 48 PD patients were included in the study. Uric acid and 25-hydroxyvitamin D were determined simultaneously in each patient’s serum. Mean serum uric acid and 25-hydroxyvitamin D levels of the patients were compared with each other. The cases where the P-value was below 0.05 were considered statistically significant. RESULTS: There was a statistically significant positive correlation between mean serum uric acid and 25-hydroxyvitamin D levels in PD patients (p=0.003; r=0.427). CONCLUSION: Serum uric acid and 25-hydroxyvitamin D levels in peritoneal dialysis patients may be indicative of dietary incompatibility. Prospective studies involving more patients are needed in PD patients to prove a relationship between these two serum markers.

Özet

AMAÇ: Periton diyaliz (PD) hastalarında, serum 25-hidroksivitamin D seviyesinin düşüklüğükardiyovasküler olay riskinin artışıyla ilişkilidir. Kronik böbrek hastalığı olan hastalarda hiperürisemi,mortalite oranında artış ile birliktedir. Çalışmamızın amacı, PD hastalarında serum ürik asit ve25-hidroksivitamin D arasında bir ilişki olup olmadığını saptamaktır.GEREÇ ve YÖNTEMLER: Çalışmaya 48 PD hastası dahil edildi. Her bir hastanın serumundanürik asit ve 25-hidroksivitamin D eş zamanlı tayin edildi. Hastaların ortalama serum ürik asit ve25-hidroksivitamin D seviyesi birbiriyle karşılaştırıldı. P-değerinin 0,05’in altında olduğu durumlaristatistiksel olarak anlamlı kabul edildi.BULGULAR: Periton diyalizi hastalarında, ortalama serum ürik asit ve 25-hidroksivitamin D seviyesiarasında istatistiksel anlamlı pozitif yönde bir ilişki saptandı (p=0,003; r=0,427).SONUÇ: PD hastalarında serum ürik asit ve 25-hidroksivitamin D seviyesi, diyet uyumsuzluğununbir göstergesi olabilir. PD hastalarında bu iki serum belirteci arasında bir ilişkinin gösterilebilmesi içindaha fazla hasta içeren prospektif çalışmalara ihtiyaç vardır.

🔖

Cite This Article

BEK, S. G., EREN, N., TUNCAY, M., YAVUZ, S., BAKIRDÖĞEN, S. (2022). The Association Between Serum Uric Acid and 25-Hydroxyvitamin D in Peritoneal Dialysis Patients. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 27 - Sayı: 2, 162–165. https://ajindex.com/articles/636038

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Foley RN, Parfrey PS: Cardiovascular disease and mortality in ESRD. J Nephrol 1998;11:239-245 2. Xia X, Luo Q, Li B, Lin Z, Yu X, Huang F: Serum uric acid and mortality in chronic kidney disease: A systematic review and metaanalysis. Metabolism 2016;65:1326-1341 3. Li L, Yang C, Zhao Y, Zeng X, Liu F, Fu P: Is hyperuricemia an independent risk factor for new-onset chronic kidney disease?: A systematic review and meta-analysis based on observational cohort studies. BMC Nephrol 2014;15:122 4. Holick MF: Vitamin D deficiency. N Engl J Med 2007;357:266- 281 5. Levin A, Bakris GL, Molitch M, Smulders M, Tian J, Williams LA, Andress DL: Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: Results of the study to evaluate early kidney disease. Kidney Int 2007;71:31-38 6. Wang AY, Lam CW, Sanderson JE, Wang M, Chan IH, Lui SF, Sea MM, Woo J: Serum 25-hydroxyvitamin D status and cardiovascular outcomes in chronic peritoneal dialysis patients: A 3-y prospective cohort study. Am J Clin Nutr 2008;87:1631-1638 7. Takahashi S, Yamamoto T, Moriwaki Y, Tsutsumi Z, Yamakita J, Hiqashino K: Decreased serum concentrations of 1,25(OH)2- vitamin D3 in patients with gout. Metabolism 1998;47:336-338 8. Chen W, Roncal-Jimenez C, Lanaspa M, Smits G, Chonchol M, Johnson RJ, Jalal D: Uric acid suppresses 1 alpha hydroxylase in vitro and in vivo. Metabolism 2014;63:150-160 9. Peng H, Li H, Li C, Chao X, Zhang Q, Zhang Y: Association between vitamin D insufficiency and elevated serum uric acid among middle-aged and elderly Chinese Han women. PLOS One 2013;8:e61159 10. Takır M, Solak Y, Erek A, Köstek O, Oral A, Elçioğlu ÖC: Association between elevated serum uric acid and vitamin D insufficiency among the middle-aged and elderly population. Turk Neph Dial Transpl 2016;25:182-186 11. Kalantar-Zadeh K, Kopple JD, Block G, Humphreys MH: A malnutrition-inflammation score correlated with morbidity and mortality in maintenance hemodialysis patients. Am J Kidney Dis 2001;38:1251-1263 12. Vanholder R, Patel S, Hsu CH: Effect of uric acid on plasma levels of 1,25(OH)2D in renal failure. J Am Soc Nephrol 1993;4:1035- 1038 13. Ebert R, Jovanovic M, Ulmer M, Schneider D, Meissner-Weigl J, Adamski J, Jakob F: Down-regulation by nuclear factor κB of human 25-hydroxyvitamin D3 1α-hydroxylase promoter. Mol Endocrinol 2004;18:2440-2450 14. Holick MF: Vitamin D status: Measurement, interpretation, and clinical application. Ann Epidemiol 2009;1