Journals / Türk Mikrobiyoloji Cemiyeti Dergisi / 2019 / Cilt: 49 - Sayı: 3

Gut Microbiota as the Mechanism Enabling the Effects of Environment and Diet on Autism

Çevresel Etkenler ve Beslenmenin Otizme Etkisini Olası Kılan Mekanizma: Bağırsak Mikrobiyotası

Pages
113–117
Publication Date
2022-11-04
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This discourse is concluded by proposing combined treatments that target the gut microbiota for individuals with ASD.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Autism spectrum disorder (ASD) is a neurodevelopmental difference with rising prevalence and no known etiology.
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Key Findings & Data:This article discusses the mechanism by which the environmental factors suggested to play a role in the emergence of ASD may influence a neurological disorder.
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Conclusion & Impact:This discourse is concluded by proposing combined treatments that target the gut microbiota for individuals with ASD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental difference with rising prevalence and no known etiology. This article discusses the mechanism by which the environmental factors suggested to play a role in the emergence of ASD may influence a neurological disorder. The global interest in gut microbiota in the recent years produced research results that reveal how these bacteria are affected by environmental factors and how they can affect the nervous system. The effects of environmental factors and diet on gut microbiota have also begun to emerge in the recent years. In this article, these findings are overviewed and their significance is discussed. This discourse is concluded by proposing combined treatments that target the gut microbiota for individuals with ASD.

Özet

Otizm spektrum bozukluğu (OSB), nedeni henüz bilinmeyen ve giderek yaygınlığı artan nörogelişimsel bir farklılıktır. Bu makale, OSB’nin ortaya çıkmasında rolü olduğu öne sürülen çevreseletkenlerin hangi mekanizma üzerinden nörolojik bir rahatsızlığı etkileyebileceği konusunu elealmaktadır. Son yıllarda bağırsak mikrobiyotasına olan ilgi ve bu doğrultuda yapılan çalışmalar,bu bakterilerin çevresel faktörlerden nasıl etkilendiğini ve sinir sistemi üzerinde nasıl etkileroluşturabildiğini göstermiştir. Çevresel etkenler ve beslenmenin bağırsak mikrobiyotası üzerindeki etkileri de son yıllarda açığa çıkmaya başlamıştır. Makalede, bu çalışmalar derlenerekbulguları ve önemleri tartışılmış, son olarak ise bu bilgiler ışığında otizm için oluşturulabilecekyeni, bileşik tedaviler önerilmiştir

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Cite This Article

DOENYAS, C. (2022). Gut Microbiota as the Mechanism Enabling the Effects of Environment and Diet on Autism. Türk Mikrobiyoloji Cemiyeti Dergisi, Cilt: 49 - Sayı: 3, 113–117. https://ajindex.com/articles/635817

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References (13)

  1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub; 2013.
  2. London EA. The environment as an etiologic factor in autism: A new direction for research. Environ Health Perspect. 2000;108(Suppl 3):401-4.
  3. May M. Disturbing behavior: Neurotoxic effects in children. Environ Health Perspect. 2000;108(6): A262-7.
  4. Rodier PM. Developing brain as a target of toxicity. Environ Health Perspect. 1995;103(Suppl 6):S73-6.
  5. Hertz‐Picciotto I, Schmidt RJ, Krakowiak P. Understanding environmental contributions to autism: Causal concepts and the state of science. Autism Res. 2018;11(4):554-86.
  6. Reichelt KL, Ekrem J, Scott H. Gluten, milk proteins and autism: dietary intervention effects on behavior and peptide secretion. J Appl Nutr. 1990;42:CD003498.
  7. Whiteley P, Rodgers J, Savery D, Shattock P. A glutenfree diet as an intervention for autism and associated spectrum disorders: preliminary findings. Autism. 1999;3(1):45-65.
  8. Bolte ER. Autism and Clostridium tetani. Med Hypotheses. 1998;51(2);133-44.
  9. Cade R, Privette M, Fregly M, et al. Autism and schizophrenia: intestinal disorders. Nutr Neurosci. 2000;3(1):57-72.
  10. Vuong HE, Hsiao EY. Emerging roles for the gut microbiome in autism spectrum disorder. Biol Psychiatry. 2017;81(5):411-23.
  11. Yang Y, Tian J, Yang B. Targeting gut microbiome: a novel and potential therapy for autism. Life Sci. 2018;194:111-9.
  12. Finegold SM. Therapy and epidemiology of autism– clostridial spores as key elements. Med Hypotheses. 2008;70(3):508-11.
  13. Argou-Cardozo I, Zeidán-Chuliá F. Clostridium bacteria and autism spectrum conditions: A systematic review and hypothetical contribution of environmental glyphosate levels. Med Sci. 2018;6(2):pii:E29. https://doi.org/10.3390/medsci6020029. 14. van De Sande MM, van Buul VJ, Brouns FJ. Autism and nutrition: the role of the gut-brain axis. Nutr Res Rev. 2014;27(2):199-214. https://doi.org/10.1017/S095442241