Journals / Türk Mikrobiyoloji Cemiyeti Dergisi / 2022 / Cilt: 52 - Sayı: 2

Epidemiology of Candida Vaginitis in Pregnant Women

Gebelerde Candida Vajinitinin Epidemiyolojisi

Pages
109–118
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: While the rate of C. albicans identified as the causative agent of vaginitis in our hospital has declined in the last decade, the increase in C. glabrata and C. krusei is alarming.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Candida vaginitis (CV), which involves three in four women at least once in their lifetimes, poses a significant risk to pregnancy.
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Key Findings & Data:Methods: Posterior fornix swab samples were taken from 250 randomly selected pregnant women presenting to our hospital between April and June 2021.
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Conclusion & Impact:Conclusion: While the rate of C. albicans identified as the causative agent of vaginitis in our hospital has declined in the last decade, the increase in C. glabrata and C. krusei is alarming.
🔬Design:Research Article
📍Scope:2021 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Candida vaginitis (CV), which involves three in four women at least once in their lifetimes, poses a significant risk to pregnancy. This study aimed to determine the prevalence of CV in women undergoing followup routine pregnancy examinations, its distribution by trimester, and the most common causative species and to compare identification methods. Methods: Posterior fornix swab samples were taken from 250 randomly selected pregnant women presenting to our hospital between April and June 2021. The samples were evaluated by direct microscopic examinations, Gram staining, and fungal cultures (CHROMagar Candida [CAC] and Sabouraud glucose agar). Yeast isolates were identified by germ-tube tests, micromorphology on corn meal–Tween 80 agar, colony appearance on CAC, and the MALDI-TOF MS. Results: The prevalence of fungal vaginitis was 43.2%. Of the 108 diagnosed patients with fungal vaginitis, 20.4% experienced recurrent vaginitis, and 82.4% were in the second or third trimester (p>.05). The most common fungal species were Candida albicans (49.6%), followed by C. glabrata (35.3%), C. krusei (7.5%), C. kefyr (3.4%), C. tropicalis (1.7%), Saccharomyces cerevisiae (1.7%), and C. dubliniensis (0.8%). Polyfungal populations were present in 10 cases (9.3%), in which C. albicans + C. glabrata (60%) was the most common coexistence. Conclusion: While the rate of C. albicans identified as the causative agent of vaginitis in our hospital has declined in the last decade, the increase in C. glabrata and C. krusei is alarming.

Özet

Amaç: Her dört kadından üçünün yaşamları boyunca en az bir kez maruz kaldığı Candida vajiniti (CV)’nin en önemli risk faktörlerinden birisi de gebeliktir. Sunulan çalışmada, rutin gebelik takibi yapılan kadınlarda CV’nin prevalansı, trimesterlere göre dağılımı, etken mantar türlerinin belirlenmesi ve identifikasyon yöntemlerinin karşılaştırılması amaçlandı. Yöntem: Nisan 2021–Haziran 2021 tarihleri arasında hastanemize başvuran rastgele seçilmiş 250 gebeden posterior forniks sürüntü örneği alındı. Klinik örnekler, doğrudan mikroskop incelemesi, Gram boyaması, mantar kültürleri (CHROMagar Candida [CAC] ve Sabouraud glikoz agar) ile değerlendirildi. İzole edilen maya mantarları germ-tüp testi, mısır unlu–tween 80 agarda yapısal özelliklerinin değerlendirilmesi, CAC’da üreme özellikleri ve MALDI-TOF MS yöntemi ile identifiye edildi. Bulgular: Mantar vajinitlerinin prevalansı %43.2 idi. Mantar vajinitli 108 olgunun 22’si (%20.4) rekürren vajinit atakları tarif etti ve olguların %82.4’ü ikinci ve üçüncü trimesterde idi (p>.05). En sık izole edilen mantar türü Candida albicans (%49.6) olup, diğer türler C. glabrata (%35.3), C. krusei (%7.5), C. kefyr (%3.4), C. tropicalis (%1.7), Saccharomyces cerevisiae (%1.7) ve C. dubliniensis (%0.8) idi. Polifungal popülasyon 10 olguda (%9.3) görüldü ve en sık C. albicans + C. glabrata (%60) birlikteliği bulundu. Sonuç: Geçtiğimiz 10 yıl içerisinde, hastanemizde vajinit etkeni olarak belirlenen C. albicans oranı azalma eğiliminde iken, C. glabrata ve C. kruseideki artış endişe vericidir.

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Cite This Article

CHAABAAWI, A., SUCU, M., KARAKOYUN, A. S., ÜNAL, N., KARA, E. (2022). Epidemiology of Candida Vaginitis in Pregnant Women. Türk Mikrobiyoloji Cemiyeti Dergisi, Cilt: 52 - Sayı: 2, 109–118. https://ajindex.com/articles/635712

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References (2)

  1. Seyedmousavi S, İlkit M, Durdu M, et al. Candida ve kandidoz: Epidemiyoloji, tanı, tedavi, antifungal ilaç direnci ve konağın genetik yatkınlığında güncel durum. Turk Mikrobiyol Cemiy Derg. 2015;45(1):1-11. https://doi.org/10.5222/TMCD.2015.001 Sobel JD. Vulvovaginal candidosis. Lancet. 2007;369(9577):1961-71. https://doi.org/10.1016/S0140-6736(07)60917-9.
  2. Denning DW, Kneale M, Sobel JD, Rautemaa-Richardson R. Global burden of recurrent vulvovaginal candidiasis: A systematic review. Lancet Infect Dis. 2018;18(11):e339-47. https://doi.org/10.1016/S1473-3099(18)30103-8 4. Sustr V, Foessleitner P, Kiss H, Farr A. Vulvovaginal candidosis: Current concepts, challenges and perspectives. J Fungi (Basel). 2020;6(4):267. https://doi.org/10.3390/jof6040267 5. Gonçalves B, Ferreira C, Alves CT, Henriques M, Azeredo J, Silva S. Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors. Crit Rev Microbiol. 2016;42(6):905-27. https://doi.org/10.3109/1040841X.2015.1091805 6. Hilmioğlu-Polat S, Seyedmousavi S, Ilkit M, et al. Estimated burden of serious human fungal diseases in Turkey. Mycoses. 2019;62(1):22-31. https://doi.org/10.1111/myc.12842 7. Aguin TJ, Sobel JD. Vulvovaginal candidiasis in pregnancy. Curr Infect Dis Rep 2015;17(6):462. https://doi.org/10.1007/s11908-015-0462-0 8. Ilkit M, Guzel AB. The epidemiology, pathogenesis, and diagnosis of vulvovaginal candidosis: A mycological perspective. Crit Rev Microbiol. 2011;37(3):250-61. https://doi.org/10.3109/1040841X.2011.576332 9. Maki Y, Fujisaki M, Sato Y, Sameshima H. Candida chorioamnionitis leads to preterm birth and adverse fetal-neonatal outcome. Infect Dis Obstet Gynecol. 2017;2017:9060138. https://doi.org/10.1155/2017/9060138 10. Guzel AB, Ilkit M, Akar T, Burgut R, Demir SC. Evaluation of risk factors in patients with vulvovaginal candidiasis and the value of chromID Candida agar versus CHROMagar Candida for recovery and presumptive identification of vaginal yeast species. Med Mycol. 2011;49(1):16-25. https://doi.org/10.3109/13693786.2010.497972 11. Ozcan K, Ilkit M, Ates A, Turac-Bicer A, Demirhindi H. Performance of Chromogenic Candida agar and CHROMagar Candida in recovery and presumptive identification of monofungal and polyfungal vaginal isolates. Med Mycol. 2010;48(1):29-34. https://doi.org/10.3109/13693780802713224 12. Pincus DH, Orenga S, Chatellier S. Yeast identification– past, present, and future methods. Med Mycol. 2007;45(2):97-121. https://doi.org/10.1080/13693780601059936 13. G