Journals / Türk Klinik Biyokimya Dergisi / 2015 / Cilt: 13 - Sayı: 1

Levels of Ferritin, Vitamin B12 and Folic Acid in Patients with Vitiligo in Usak Region

Uşak Yöresinde Vitiligo Hastalarında Ferritin, Vitamin B12 ve Folik Asit Düzeyleri

Pages
15–20
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We recommend that vitamin B12 and folic acid deficiency in patients with vitiligo were evaluated in the outpatient clinical examination and laboratory tests are done periodically in follow-up

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Vitiligo is an acquired depigmentation disorder occur with destruction of melanocytes, a common skin disease.
📊
Key Findings & Data:We aimed to investigate ferritin, vitamin B12 and folic acid levels in patients with vitiligo in Usak region.
💡
Conclusion & Impact:We recommend that vitamin B12 and folic acid deficiency in patients with vitiligo were evaluated in the outpatient clinical examination and laboratory tests are done periodically in follow-up
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Vitiligo is an acquired depigmentation disorder occur with destruction of melanocytes, a common skin disease. We aimed to investigate ferritin, vitamin B12 and folic acid levels in patients with vitiligo in Usak region. Material and Methods: A hundred and two cases with vitiligo (60 female and 42 male) and a hundred and two control subjects (60 female and 42 male) were enrolled in this study. Ferritin, vitamin B12 and folic levels were measured by Advia Centaur XP (Siemens, USA). The collected data were analyzed by SPSS version11.5. Results: Comparing the patients and control subjects, the mean values of ferritin were found a statistically significant difference between groups (p = 0.664). The mean values of vitamin B12 and folic acid have detected statistically significant difference between groups (p = 0.041 and p = 0.025, respectively). Conclusion: Vitamin B12 and folic acid may play a role in the pathogenesis of vitiligo disease. We recommend that vitamin B12 and folic acid deficiency in patients with vitiligo were evaluated in the outpatient clinical examination and laboratory tests are done periodically in follow-up

Özet

Amaç: Vitiligo yaygın bir deri hastalığı olup melanositlerin destruksiyonu ile seyreden kazanılmış bir depigmentasyon bozukluğudur. Çalışmamızın amacı Uşak yöresinde vitiligo hastalarında ferritin, vitamin B12 ve folik asit düzeylerinin araştırılmasıdır. Gereç ve Yöntem: Çalışmamıza 102 (60 kadın ve 42 erkek) vitiligolu hasta ve 102 (60 kadın ve 42 erkek) kontrol bireyi dahil edildi. Serum ferritin, vitamin B12 ve folik asit düzeyleri Advia Centaur XP (Siemens, USA) cihazında kendi kitleriyle ölçüldü. Bulgular: Hasta ve kontrol grubu ferritin ortalama değerleri açısından karşılaştırıldığında iki grup arasında istatistiksel olarak anlamlı fark saptanmadı (p=0,664). Vitamin B12 ve folik asit ortalama değerleri arasında anlamlı istatistiksel fark tespit ettik (sırasıyla p=0,041 ve p=0,025). Sonuç: Vitamin B12 ve folik asit vitiligo hastalığının etyopatogenezinde rol oynayabilir. Vitiligo hastalarının polikliniklerde vitamin B12 ve folik asit eksikliği açısından değerlendirilerek klinik inceleme ve laboratuvar testlerinin yapılarak periyodik takip edilmelerini tavsiye ediyoruz

🔖

Cite This Article

KIRTAY, M., ETEM, E. Ö., ETEM, A. A., YILDIRMAK, S. T. (2022). Levels of Ferritin, Vitamin B12 and Folic Acid in Patients with Vitiligo in Usak Region. Türk Klinik Biyokimya Dergisi, Cilt: 13 - Sayı: 1, 15–20. https://ajindex.com/articles/634435

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Jean-Paul Ortonne. Vitiligo and other disorders of hypopigmentation. In:. Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. 1st edition. St. Louis: Mosby; 2003: 947-55
  2. Lotti T, Gori A, Zanieri F, et al. Vitiligo: new and emerging treatments. Dermatol Ther 2008; 21:110-7
  3. Forschner T, Buchholtz S, Stockfleth E. Current state of vitiligo therapy--evidence-based analysis of the literature. J Dtsch Dermatol Ges 2007; 5:467-75
  4. Halder RM, Chappell JL. Vitiligo update. Semin Cutan Med Surg 2009; 28:86-92
  5. Schallreuter KU, Bahadoran P, et al. Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Exp Dermatol 2008; 17:139-40
  6. Mosher DB, Fitzpatrick TB, Ortanne JB. Disorders of Pigmentation, Hipomelanoses and Hypermelanoses. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, Fitzpatrick TB, eds. Fitzpatrick’s Dermatology in General Medicine, 5th ed. New York, Mc Graw Hill, 1999: 936-45
  7. Montes LF, Dias ML, Lajous J, Garcia NJ. Folic acid and vitamin B12 in vitiligo: a nutritional approach. Cutis 1992; 50:39-42
  8. Kim SM. Serum levels of folic acid and vitamin B12 in Korean patients with vitiligo. Yonsei Med J 1999; 40:195-8
  9. El-Batawi MMY, El-Tawil NEA, El-Tawil AEA. Serum levels of vitamin B12 and folic acid in Egyptian patients with vitiligo. Egypt J Derm Androl 2001;21:77-80
  10. Juhlin L, Olsson MJ. Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the importance of sun exposure. Acta Derm Venereol. 1997;77:460-2
  11. Shaker OG, El-Tahlawi SM. Is there a relationship between homocysteine and vitiligo?A pilot study. Br J Dermatol 2008;159:720-4
  12. Robinson K. Homocysteine, B vitamins, and risk of cardiovascular disease. Heart 2000;83:127-30
  13. Mudd SH, Levy HL, Skorby LF. Disorders of transsulfuration. In: The Metabolic and Molecular Basis of Inherited Disease (Scriver CR, Beudet AL, Sly WS, Valle D, eds), 7th edn. New York: McGrawHill, 1995;1279-327
  14. Guilland JC, Favier A, Potier de Courcy G et al. Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease
  15. Basic data. [In French]. Pathol Biol (Paris) 2003; 51:101- 10
  16. Reish O, Townsend D, Berry SA et al. Tyrosinase inhibition due to interaction of homocysteine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet 1995; 57:127-32