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Journals / Türk Klinik Biyokimya Dergisi / 2019 / Cilt: 17 - Sayı: 1

Iron Deficiency Anemia and β-Thalassemia Minor Differantiation With Hematological Indices

Demir Eksikliği Anemisi ve Beta Talasemi Minör Ayırımında Kullanılan Hematolojik İndeksler

Giray BOZKAYA
Sibel BİLGİLİ
Nuriye UZUNCAN
Sezen ŞAHİN
Pages
29–39
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

RBC, GK, SI and RDWIcould be used as a screening tool rather than discrimination indices.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Iron Deficiency Anemia (IDA) and Beta Thalassemia Minor (BTM) are the most common causes of microcytic hypochromic anemia.
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Key Findings & Data:In our study, the performance oftwelve indices were tested to distinguish IDA from BTM, two common causes of microcytic anemia.Materials and methods: There were two groups which were evaluated as IDA and BTM, we examined the diagnostic accuracy of five red cell parameters [red blood cell (RBC), mean corpuscular volume (MCV), hemoglobin (Hb) ,mean corpuscular hemoglobin (MCH), red blood cell distribution width (RDW)] and we calculated twelve indices [Menzier Index (MI), Green and King (GK), Red Blood Cell Distribution Width Index (RDWI), England & Fraser (EF), RBC, Sirdah Index (SI), Ricarca Index (R), Srivastava (S), Shine & Lal (SL), Ehsani (E), Red Cell Distribution Width (RDW), 11T].Results: Among the twelve discrimination indices, 11T index was the most efficient in differentiating IDA from BTM. 11T index had the highest Youden’s index (69,8%) and accuracy (81,2%).Conclusion: 11T index was the most effective in discriminating IDA from BTM.
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Conclusion & Impact:RBC, GK, SI and RDWIcould be used as a screening tool rather than discrimination indices.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Iron Deficiency Anemia (IDA) and Beta Thalassemia Minor (BTM) are the most common causes of microcytic hypochromic anemia. In the last four decades many formulas have been proposed to discriminate between two common causes of microcytic hypochromic anemia. An ideal discrimination index should have a high sensitivity and specificity and should be easy to calculate. The distinction between IDA and BTM is important in many respects. In our study, the performance oftwelve indices were tested to distinguish IDA from BTM, two common causes of microcytic anemia.Materials and methods: There were two groups which were evaluated as IDA and BTM, we examined the diagnostic accuracy of five red cell parameters [red blood cell (RBC), mean corpuscular volume (MCV), hemoglobin (Hb) ,mean corpuscular hemoglobin (MCH), red blood cell distribution width (RDW)] and we calculated twelve indices [Menzier Index (MI), Green and King (GK), Red Blood Cell Distribution Width Index (RDWI), England & Fraser (EF), RBC, Sirdah Index (SI), Ricarca Index (R), Srivastava (S), Shine & Lal (SL), Ehsani (E), Red Cell Distribution Width (RDW), 11T].Results: Among the twelve discrimination indices, 11T index was the most efficient in differentiating IDA from BTM. 11T index had the highest Youden’s index (69,8%) and accuracy (81,2%).Conclusion: 11T index was the most effective in discriminating IDA from BTM. RBC, GK, SI and RDWIcould be used as a screening tool rather than discrimination indices.

Özet

Amaç: Demir Eksikliği Anemisi (IDA) ve Beta Talasemi Minör (BTM), mikrositer hipokrom aneminin en sık nedenlerindendir. Son yıllarda, mikrositer hipokrom aneminin bu nedenleri arasında ayrımın yapılması için birçok formül önerilmiştir. İdeal bir ayrım indeksi yüksek duyarlılığa ve özgüllüğe sahip olmalı ve hesaplanması kolay olmalıdır. IDA ve BTM arasındaki ayrım pek çok açıdan önemlidir. Bizim çalışmamızda 12 indeksin performansı, mikrositik aneminin iki yaygın nedeni olan BTM'yi IDA'dan ayırt etmek için test edildi.Gereç ve Yöntemler: IDA ve BTM olarak değerlendirilen iki grup vardı. Beş kırmızı kan hücre parametresi [kırmızı kan hücresi (RBC), ortalama korpusküler hacim (MCV), hemoglobin (Hb), ortalama korpusküler hemoglobin (MCH), kırmızı kan hücresi dağılım genişliği (RDW)] çalışıldı ve on iki indeks [Menzier İndeksi (MI), Greenl ve King (GK), Kırmızı Kan Hücresi Dağılım Genişliği İndeksi (RDWI),Egland ve Fraser (EF), RBC, Sirdah İndeksi (SI) Ricarca İndeksi (R), Srivastava (S), Shine & Lal (SL), Ehsani (E), Kırmızı Hücre Dağılım Genişliği (RDW), 11T] hesaplandı.Bulgular: On iki ayrıcı indeksden 11T indeksi, BTM'yı IDA'dan ayırmada en etkili olanıydı. 11T indeksi en yüksek Youden indeksine (% 69,8) ve doğruluğa (% 81,2) sahipti.Sonuç: BTM'den IDA'yı ayırt etmede 11T indeksi en etkiliydi. RBC, GK, SI ve RDWI ise ayrım indeksleri yerine bir tarama aracı olarak kullanılabilir.

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Cite This Article

BOZKAYA, G., BİLGİLİ, S., UZUNCAN, N., ŞAHİN, S. (2022). Iron Deficiency Anemia and β-Thalassemia Minor Differantiation With Hematological Indices. Türk Klinik Biyokimya Dergisi, Cilt: 17 - Sayı: 1, 29–39. https://ajindex.com/articles/634362

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