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Journals / Türk Klinik Biyokimya Dergisi / 2020 / Cilt: 18 - Sayı: 3

The Need for a New Cut-off Value for CA 19-9 in Patients with Type II Diabetes Mellitus

Tip II Diabetes Mellituslu Hastalarda CA 19-9 için Yeni Bir Cut-off Değeri İhtiyacı

Fatma Demet Arslan
Inanc Karakoyun
Pages
165–169
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The correlation between CA 19-9 andglucose, HbA1c, insulin and HOMA-IR was evaluated.Results: The type II DM group had significantly higher CA 19-9, glucose, HbA1c, insulin, as well asHOMA-IR levels compared to the NGR group (P=0.001 for CA 19-9 and P

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Pancreatic cancer (PC) is a disease with complex and poorly understood etiology.
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Key Findings & Data:Increased carbohydrate antigen (CA) 19-9 levelscan be used as a biomarker in diagnosis of PC.
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Conclusion & Impact:The correlation between CA 19-9 andglucose, HbA1c, insulin and HOMA-IR was evaluated.Results: The type II DM group had significantly higher CA 19-9, glucose, HbA1c, insulin, as well asHOMA-IR levels compared to the NGR group (P=0.001 for CA 19-9 and P
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Pancreatic cancer (PC) is a disease with complex and poorly understood etiology. One of thecommon risk factors of PC is diabetes mellitus (DM). Increased carbohydrate antigen (CA) 19-9 levelscan be used as a biomarker in diagnosis of PC. However, CA 19-9 levels have been reported to increasein some benign conditions as well. Increased levels of such PC-associated biomarkers due to benignconditions can lead to unnecessary interventional procedures. The aim of this study was to question theneed for a new CA 19-9 cut-off value when diagnosing PC in patients with type II DM.Material and Methods: This retrospective study evaluated a total of 449 patients. The patients weredivided into two groups: the normal glucose regulation (NGR) group (n=292) and type II DM group(n=157). The mean glucose, HbA1c, CA 19-9, insulin, and homeostatic model assessment for insulinresistance (HOMA-IR) levels of the groups were compared. The correlation between CA 19-9 andglucose, HbA1c, insulin and HOMA-IR was evaluated.Results: The type II DM group had significantly higher CA 19-9, glucose, HbA1c, insulin, as well asHOMA-IR levels compared to the NGR group (P=0.001 for CA 19-9 and P

Özet

Amaç: Pankreas kanseri (PC), karmaşık ve iyi anlaşılmayan etiyolojisi olan bir hastalıktır. PC'nin yaygın risk faktörlerinden biri diabetes mellitus'tur (DM). Artmış karbonhidrat antijeni (CA) 19-9 seviyeleri PC tanısında biyobelirteç olarak kullanılabilir. Bununla birlikte, CA 19-9 seviyelerinin bazı benign durumlarda da arttığı bildirilmiştir. Benign durumlar nedeniyle PC ile ilişkili bu tür biyobelirteçlerin artan seviyeleri gereksiz girişimsel prosedürlere yol açabilir. Bu çalışmanın amacı tip II DM'li hastalarda PC tanısı koyarken yeni bir CA 19-9 eşik değerinin gerekliliğini sorgulamaktı. Gereç ve Yöntem: Bu retrospektif çalışmada toplam 449 hasta değerlendirildi. Hastalar iki gruba ayrıldı: normal glukoz regülasyonu (NGR) grubu (n = 292) ve tip II DM grubu (n = 157). Grupların ortalama glukoz, HbA1c, CA 19-9, insülin ve insülin direnci için homeostatik model değerlendirmesi (HOMA-IR) düzeyleri karşılaştırıldı. CA 19-9 ile glukoz, HbA1c, insülin ve HOMA-IR arasındaki korelasyon değerlendirildi. Bulgular: Tip II DM grubu, NGR grubuna kıyasla anlamlı derecede yüksek CA19-9, glukoz, HbA1c, insülin ve de HOMA-IR seviyelerine sahipti (CA 19-9 için P=0.001 ve diğer tüm ikili karşılaştırmalarda P

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Cite This Article

Arslan, F. D., Karakoyun, I. (2022). The Need for a New Cut-off Value for CA 19-9 in Patients with Type II Diabetes Mellitus. Türk Klinik Biyokimya Dergisi, Cilt: 18 - Sayı: 3, 165–169. https://ajindex.com/articles/634329

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