Journals / Türk Kardiyoloji Derneği Arşivi / 2005 / Cilt: 33 - Sayı: 4

The effect of glycoprotein IIb/IIIa inhibition on ST-segment resolution following successful primary percutaneous coronary interventions

Glikoprotein IIb/IIIa blokajının başarılı primer perkütan koroner girişim sonrasında ST-segment gerilemesi üzerine etkisi

Pages
204–211
Publication Date
2022-11-05
DOI
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Patients who received tirofiban had a greater ∆STR than those who did not (7.2±2.8 mm vs 4.2±2.6 mm, respectively; p

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Objective & Hypothesis:Objectives: We evaluated the effect of glycoprotein (GP) IIb/IIIa receptor inhibition on ST-segment resolution in patients undergoing primary percutaneous coronary intervention (PCI) for acute myocardial infarction (MI).
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Key Findings & Data:Study design: We retrospectively analyzed 115 patients (96 males, 19 females; mean age 57.7 years; range 39 to 82 years) who presented with ST-segment elevation acute MI and treated within 12 hours with successful primary PCI (TIMI III flow).
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Conclusion & Impact:Patients who received tirofiban had a greater ∆STR than those who did not (7.2±2.8 mm vs 4.2±2.6 mm, respectively; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: We evaluated the effect of glycoprotein (GP) IIb/IIIa receptor inhibition on ST-segment resolution in patients undergoing primary percutaneous coronary intervention (PCI) for acute myocardial infarction (MI). Study design: We retrospectively analyzed 115 patients (96 males, 19 females; mean age 57.7 years; range 39 to 82 years) who presented with ST-segment elevation acute MI and treated within 12 hours with successful primary PCI (TIMI III flow). Of these, a GP IIb/IIIa receptor blocker (tirofiban) was used in 64 patients. The arithmetic sum of ST-segments was obtained in millimeters on electrocardiograms immediately before angioplasty and after 60 minutes of TIMI III flow restoration. The difference between the two measurements was accepted as resolution of the sum of ST-segment elevation and expressed as ∆STR. Results: There were no significant differences between the two treatment groups regarding age, gender, cardiovascular risk factors, laboratory parameters, duration from angina onset to emergency service and from door to angioplasty. Patients who received tirofiban had a greater ∆STR than those who did not (7.2±2.8 mm vs 4.2±2.6 mm, respectively; p

Özet

Amaç: Akut miyokard infarktüsü (Mİ) nedeniyle başarılı primer perkütan koroner girişim (PKG) uygulanan hastalarda glikoprotein (GP) IIb/IIIa reseptör blokajının ST-segment yükselmesini geriletici etkisi değerlendirildi. Çalışma planı: Akut ST-segment yükselmeli Mİ geçiren ve 12 saat içinde başarılı primer PKG uygulanan (TIMI III akım) 115 hasta (96 erkek, 19 kadın; ort. yaş 57.7; dağılım 39-82) geriye dönük olarak değerlendirildi. Bir grup hastada GP IIb/IIIa reseptör blokeri (tirofiban) kullanılırken (n=64), bir grubunda kullanılmadı (n=51). Hastaların PKG öncesi ve TIMI III akım sağlandıktan 60 dakika sonraki elektrokardiyografi (EKG) kayıtlarında toplam ST-segment yükselme miktarları milimetre cinsinden ölçüldü. İki ölçüm arasındaki fark toplam ST-segment yükselmesindeki gerileme olarak kabul edildi ve ∆STG olarak ifade edildi. Bulgular: İki grup arasında yaş, cinsiyet, kardiyovasküler risk faktörleri, laboratuvar değerleri, göğüs ağrısı başlangıcı-acil ünitesi başvuru ve kapı-balon süreleri açısından anlamlı fark yoktu. GP IIb/IIIa reseptör blokeri kullanılan grupta ∆STG daha fazla bulundu (7.2±2.8 mm’ye karşı 4.2±2.6 mm, p

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Cite This Article

KAŞIKÇIOĞLU, H., ERDEM, İ., ŞİMŞEK, D., GÜRDOĞAN, M., UYAREL, H., ÇAM, N., DAYİ, Ü. Ş., AKGÜL, Ö., ÖKMEN, E., TARTAN, Z., KARABULUT, A. (2022). The effect of glycoprotein IIb/IIIa inhibition on ST-segment resolution following successful primary percutaneous coronary interventions. Türk Kardiyoloji Derneği Arşivi, Cilt: 33 - Sayı: 4, 204–211. https://ajindex.com/articles/633773

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