Journals / Türk Kardiyoloji Derneği Arşivi / 2009 / Cilt: 37 - Sayı: 1

The effect of statin treatment on inflammation in patients with metabolic syndrome

Metabolik sendromlu hastalarda statin tedavisinin inflamasyon üzerine etkisi

Pages
26–34
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Fluvastatin treatment resulted in significant decreases in levels of total cholesterol, LDL cholesterol, triglyceride (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Inflammation plays an important role in the pathogenesis of metabolic syndrome (MS).
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Key Findings & Data:Study design: The study included 47 patients (36 females; 11 males; mean age 55±8 years) with MS.
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Conclusion & Impact:Results: Fluvastatin treatment resulted in significant decreases in levels of total cholesterol, LDL cholesterol, triglyceride (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Inflammation plays an important role in the pathogenesis of metabolic syndrome (MS). We investigated the effect of fluvastatin treatment on inflammatory markers in patients with MS. Study design: The study included 47 patients (36 females; 11 males; mean age 55±8 years) with MS. The diagnosis of MS was based on the presence of at least three criteria of the NCEP ATP III guidelines. All the patients received 80 mg fluvastatin treatment for six weeks. Laboratory parameters were measured before and after treatment, and flow cytometric analysis of peripheral blood leukocytes was performed. The results were compared with those of 47 age- and sexmatched healthy controls (33 females, 14 males; mean age 52±8 years). Results: Fluvastatin treatment resulted in significant decreases in levels of total cholesterol, LDL cholesterol, triglyceride (p

Özet

Amaç: Metabolik sendromun (MS) patogenezinde inflamasyon önemli rol oynamaktadır. Bu çalışmada, MS’li hastalarda fluvastatin tedavisinin inflamatuvar belirteçler üzerine etkisi araştırıldı. Ça lış ma pla nı: Çalışmaya MS tanılı 47 hasta (36 kadın, 11 erkek; ort. yaş 55±8) alındı. Metabolik sendrom tanısı NCEP ATP III ölçütlerinden en az üçünün varlığıyla kondu. Bütün hastalara altı hafta boyunca 80 mg fluvastatin tedavisi uygulandı. Tedavi öncesi ve sonrasında laboratuvar parametreleri ölçüldü; periferik kan lökositleri akım sitometri yöntemiyle değerlendirildi. Hasta grubunun verileri, yaş ve cinsiyet uyumlu 47 sağlıklı bireyden (33 kadın, 14 erkek; ort. yaş 52±8) oluşan kontrol grubuyla karşılaştırıldı. Bul gu lar: Tedavi sonrasında total kolesterol, LDL-kolesterol ve trigliserid düzeylerinde (p

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Cite This Article

SAYIN, M. R., KALAYCIOĞLU, E., ONUK, T., DOĞAN, S. M., YILDIRIM, N., MADAK, H., DEMİRCİ, E., AKTOP, Z., ÇETİNER, M. A., KARAASLAN, S., AYDIN, M. (2022). The effect of statin treatment on inflammation in patients with metabolic syndrome. Türk Kardiyoloji Derneği Arşivi, Cilt: 37 - Sayı: 1, 26–34. https://ajindex.com/articles/633402

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