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Journals / Türk Kardiyoloji Derneği Arşivi / 2010 / Cilt: 38 - Sayı: 8

The effects of thyroid hormones and interleukin-8 levels on prognosis after congenital heart surgery

Doğuştan kalp cerrahisinde tiroit fonksiyonları ve interlökin-8 değerlerinin prognoz üzerine etkisi

Hasan SUNAR
Tuncer KOÇAK
Rahmi ZEYBEK
Ahmet ŞAŞMAZEL
Ayşe İnci YILDIRIM
Ayşe BAYSAL
Pages
537–543
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

While the two groups were similar with respect to preoperative levels of thyroid hormones, lactate, and IL-8, postoperative tT3 and fT3 levels were significantly lower, and lactate and IL-8 levels were significantly higher in the LCOS group (p

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Objective & Hypothesis:Objectives: We evaluated the effects of thyroid hormone levels and interleukin-8 levels on prognosis in patients undergoing congenital heart surgery under cardiopulmonary bypass (CPB).Study design: The study included 41 consecutive children (19 boys, 22 girls; mean age 3.4±3.1 years; range 0.3 to 12 years).
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Key Findings & Data:The definition of LCOS included oliguria, tachycardia, metabolic acidosis, and increased plasma lactate level.
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Conclusion & Impact:While the two groups were similar with respect to preoperative levels of thyroid hormones, lactate, and IL-8, postoperative tT3 and fT3 levels were significantly lower, and lactate and IL-8 levels were significantly higher in the LCOS group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: We evaluated the effects of thyroid hormone levels and interleukin-8 levels on prognosis in patients undergoing congenital heart surgery under cardiopulmonary bypass (CPB).Study design: The study included 41 consecutive children (19 boys, 22 girls; mean age 3.4±3.1 years; range 0.3 to 12 years). The patients were divided into two groups based on the presence or absence of postoperative low cardiac output state (LCOS). The definition of LCOS included oliguria, tachycardia, metabolic acidosis, and increased plasma lactate level. Plasma total (tT4) and free (fT4) thyroxine, total (tT3) and free (fT3) triiodothyronine, thyroid stimulating hormone (TSH), and interleukin-8 (IL-8) levels were measured preoperatively and at 48 hours postoperatively.Results: Postoperatively, nine patients (22%) developed LCOS. While the two groups were similar with respect to preoperative levels of thyroid hormones, lactate, and IL-8, postoperative tT3 and fT3 levels were significantly lower, and lactate and IL-8 levels were significantly higher in the LCOS group (p

Özet

Amaç: Bu çalışmada doğuştan kalp hastalığı nedeniyle kardiyopulmoner baypas (KPB) ile ameliyat edilen hastalarda tiroit fonksiyonları ve interlökin-8 değerlerinin prognoz üzerine etkileri değerlendirildi.Çalışma planı: Çalışmaya ardışık 41 hasta (19 erkek, 22 kız; ort. yaş 3.4±3.1; dağılım 0.3-12) alındı. Ameliyat sonrasında düşük kardiyak debi durumu (DKDD) gelişmesine göre hastalar iki ayrı gruba ayrıldı. Düşük kardiyak debi durumu tanımında oliguri, taşikardi, metabolik asidoz gelişimi ve plazma laktat düzeyinde artış yer aldı. Ameliyat öncesinde ve ameliyat sonrası 48. saatte plazma total tiroksin (tT4), total triiyodotironin (tT3), serbest triiyodotironin (fT3), serbest tiroksin (fT4), tiroit stimülan hormon (TSH), interlökin-8 (IL-8) düzeyleri ölçüldü.Bulgular: Ameliyat sonrasında dokuz hastada (%22) DKDD gelişti. Ameliyat öncesi tiroit hormon düzeyleri, laktat ve IL-8 düzeyleri iki grupta benzer bulunurken, DKDD gelişen grupta tT3 ve fT3 düzeyleri anlamlı derecede düşük, laktat ve IL-8 düzeyleri anlamlı derecede yüksek bulundu (p

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Cite This Article

SUNAR, H., KOÇAK, T., ZEYBEK, R., ŞAŞMAZEL, A., YILDIRIM, A. İ., BAYSAL, A. (2022). The effects of thyroid hormones and interleukin-8 levels on prognosis after congenital heart surgery. Türk Kardiyoloji Derneği Arşivi, Cilt: 38 - Sayı: 8, 537–543. https://ajindex.com/articles/633312

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