Journals / Türk Kardiyoloji Derneği Arşivi / 2010 / Cilt: 38 - Sayı: 6

Evaluation of hospitalization period and five-year follow-up of patients admitted with acute coronary syndrome following coronary artery bypass graft surgery

Koroner arter baypas ameliyatından sonra akut koroner sendromla başvuran hastalarda hastaneiçi dönem ve beş yıllık izlem

Pages
387–392
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The overall mortality rate was 21.4%.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: We evaluated patients admitted with the diagnosis of acute coronary syndrome (ACS) after coronary artery bypass graft (CABG) surgery.
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Key Findings & Data:Study design: This retrospective study included 72 consecutive CABG patients (10 women, 62 men; mean age 63±9 years; range 45 to 83 years).
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Conclusion & Impact:The overall mortality rate was 21.4%.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: We evaluated patients admitted with the diagnosis of acute coronary syndrome (ACS) after coronary artery bypass graft (CABG) surgery. Study design: This retrospective study included 72 consecutive CABG patients (10 women, 62 men; mean age 63±9 years; range 45 to 83 years). Acute coronary syndrome was defined as the presence of unstable angina or myocardial infarction (MI) with or without ST elevation. Time from CABG surgery to admission with ACS was defined as bypass age. Following discharge, information was derived by phone calls from the patients or relatives on cardiovascular events within a five-year period. Results: On admission, 14 patients (19.4%) had non-ST elevation MI, nine patients (12.5%) had ST elevation MI, and 49 patients (68.1%) had unstable angina. The mean bypass age was 5.6±3.5 years. Of the study group, 38.9% were obese, 25% were diabetic, 54.2% were hypertensive, 44.4% were hyperlipidemic, and 26.4% were current smokers. Medications before admission included aspirin (81.9%), statin (25%), beta-blocker (27.8%), ACE inhibitor or angiotensin receptor blocker (27.8%), and calcium channel antagonist (36.1%). Increased LDL cholesterol (≥100 mg/dl) and decreased HDL cholesterol (≤50 mg/dl) levels were present in 55.6% and 80.6%, respectively. Mortality occurred in 15 patients, four during hospitalization, and 11 after discharge. The overall mortality rate was 21.4%. In correlation analysis, mortality was positively correlated with age (r=0.34, p=0.005), bypass age (r=0.37, p=0.001), CRP level (r=0.31, p=0.033) and negatively correlated with beta-blocker use (r=-0.25, p=0.041) and ejection fraction (r=-0.37, p=0.016). Conclusion: Our results show that, following CABG surgery, special consideration should be given to risk factor management and use of agents with proven effects against cardiovascular mortality such as statins, betablockers, and ACE inhibitors.

Özet

Amaç: Koroner arter baypas greft (KABG) ameliyatından sonra akut koroner sendrom (AKS) tanısıyla hastaneye yatırılan olgular değerlendirildi. Çalışma planı: Koroner baypaslı ardışık 72 hasta (10 kadın, 62 erkek; ort. yaş 63±9; dağılım 45-83) geriye dönük olarak incelendi. Akut koroner sendrom, kararsız angina pektoris, ST yükselmesiz miyokart enfarktüsü (ME) veya ST yükselmeli ME varlığı olarak kabul edildi. Ameliyat tarihinden AKS ile hastaneye yatırılıncaya kadar geçen süre baypas yaşı olarak tanımlandı. Taburculuktan sonra telefonla aranan hasta veya yakınlarından beş yıllık kardiyovasküler olay gelişimi açısından ayrıntılı bilgi alındı. Bulgular: Başvuru tanıları 14 olguda (%19.4) ST yükselmesiz ME, dokuz olguda (%12.5) ST yükselmeli ME, 49 olguda (%68.1) kararsız angina idi. Ortalama baypas yaşı 5.6±3.5 yıl bulundu. Olguların %38.9’u obez, %25’i diyabetik, %54.2’si hipertansif, %44.4’ü hiperlipidemik idi ve %26.4’ü sigara içiyordu. Hastaneye başvuru sırasında %81.9’u aspirin, %25’i statin, %27.8’i beta-bloker, %27.8’i ACE inhibitörü veya reseptör blokeri, %36.1’i kalsiyum antagonisti kullanıyordu. Olguların %55.6’sında LDL-kolesterol yüksek (≥100 mgr/dl), %80.6’sında HDLkolesterol düşük (≤50 mgr/dl) idi. Hastaneiçi dönemde dört, taburculuk sonrası dönemde 11 olgu olmak üzere toplam 15 olgu kaybedildi. Tüm grupta ölüm oranı %21.4 bulundu. Korelasyon analizinde, ölüm gelişimi hastanın yaşı (r=0.34, p=0.005), baypas yaşı (r=0.37, p=0.001) ve CRP düzeyi (r=0.31, p=0.033) ile pozitif ilişkili; beta-bloker kullanımı (r=-0.25, p=0.041) ve ejeksiyon fraksiyonu (r=-0.37, p=0.016) ile negatif ilişkili bulundu. Sonuç: Bulgularımız, KABG ameliyatından sonra, kardiyovasküler olay gelişimine karşı risk faktörü modifikasyonu ile statin, beta-bloker ve ACE inhibitörleri gibi mortaliteye etkisi ortaya konmuş ajanları daha yüksek oranlarda kullanmamız gerektiğini göstermektedir.

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Cite This Article

KAYIKÇIOĞLU, M., CAN, L. H., YAVUZGİL, O., SOYDAN, İ., KÜLTÜRSAY, H. (2022). Evaluation of hospitalization period and five-year follow-up of patients admitted with acute coronary syndrome following coronary artery bypass graft surgery. Türk Kardiyoloji Derneği Arşivi, Cilt: 38 - Sayı: 6, 387–392. https://ajindex.com/articles/633285

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