Journals / Türk Kardiyoloji Derneği Arşivi / 2011 / Cilt: 39 - Sayı: 7

Tedavi edilmemiş hipertansif hastalarda ve normotansif bireylerde serum ürik asit düzeyi, otonom disfonksiyon ve düşük dereceli enflamasyonun gece kan basıncı üzerine artırıcı etkileri

Incremental effects of serum uric acid levels, autonomic dysfunction, and low-grade inflammation on nocturnal blood pressure in untreated hypertensive patients and normotensive individuals

Pages
531–539
Publication Date
2022-11-05
DOI
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In univariate correlation analysis, log(MAU) showed a significant correlation with nocturnal BP (r=0.560, p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: We aimed to evaluate the associations between nocturnal blood pressure (BP) and serum uric acid (SUA) level, low-grade inflammation, and cardiac autonomic function in untreated dipper and nondipper hypertensive patients and normotensive individuals.
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Key Findings & Data:Study design: The study included 92 consecutive patients (44 men, 48 women; mean age 51.6±9.7 years) who presented for initial evaluation of hypertension.
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Conclusion & Impact:In univariate correlation analysis, log(MAU) showed a significant correlation with nocturnal BP (r=0.560, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: We aimed to evaluate the associations between nocturnal blood pressure (BP) and serum uric acid (SUA) level, low-grade inflammation, and cardiac autonomic function in untreated dipper and nondipper hypertensive patients and normotensive individuals. Study design: The study included 92 consecutive patients (44 men, 48 women; mean age 51.6±9.7 years) who presented for initial evaluation of hypertension. All patients underwent 24-hour Holter monitoring to assess heart rate variability (HRV) and ambulatory BP. Serum high-sensitivity C-reactive protein (hs-CRP) and SUA levels were measured. Due to the non-normal distribution of hs-CRP and microalbuminuria (MAU), they were normalized by logarithmic transformation. Results: Of the study group, 60 patients (65.2%) were diagnosed as hypertensive (50% nondippers). In univariate correlation analysis, log(MAU) showed a significant correlation with nocturnal BP (r=0.560, p

Özet

Amaç: Bu çalışmada tedavi edilmemiş dipper ve nondipper hipertansif hastalarda ve normotansif bireylerde gece kan basıncı (KB) ile serum ürik asit (UA) düzeyi, düşük dereceli enflamasyon ve kardiyak otonomik disfonksiyon arasındaki ilişkinin değerlendirilmesi amaçlandı. Çalışma planı: Çalışmada, hipertansiyon için ilk kez değerlendirilecek olan ardışık 92 hasta (44 erkek, 48 kadın; ort. yaş 51.6±9.7) incelendi. Tüm hastalarda kalp hızı değişkenliği (KHD) parametrelerinin değerlendirilmesi ve kan basıncı ölçümleri için 24 saatlik Holter izlemi yapıldı ve serumda yüksek duyarlıklı C-reaktif protein (hs-CRP) ve UA düzeyleri ölçüldü. Normal dağılım göstermeyen hs-CRP ve mikroalbüminüri (MAU) logaritmik dönüştürüm ile normalleştirildi. Bulgular: Çalışmada 60 hasta (%65.2) hipertansif (%50’si nondipper) bulundu. Tekdeğişkenli korelasyon analizinde log(MAU) gece KB ölçümleri ile anlamlı ilişki gösterdi (r=0.560, p

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Cite This Article

ERDEN, M., TOPAL, S., ÇENGEL, A., POYRAZ, F., ŞAHİNARSLAN, A., KOCAMAN, S. A., YALÇIN, M. R., BOYACI, B. (2022). Tedavi edilmemiş hipertansif hastalarda ve normotansif bireylerde serum ürik asit düzeyi, otonom disfonksiyon ve düşük dereceli enflamasyonun gece kan basıncı üzerine artırıcı etkileri. Türk Kardiyoloji Derneği Arşivi, Cilt: 39 - Sayı: 7, 531–539. https://ajindex.com/articles/633193

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