SavedAdd your journal

Journals / Türk Kardiyoloji Derneği Arşivi / 2011 / Cilt: 39 - Sayı: 2

Subklinik hipotiroidizmde ventrikül fonksiyonlarının doku doppler ekokardiyografi ile değerlendirilmesi

Evaluation of ventricular functions using tissue doppler echocardiography in patients with subclinical hypothyroidism

Murat USTA
Mustafa Kemal ARSLANTAŞ
Eren ÖNER
Mecdi ERGÜNEY
Selen YURDAKUL
Fatma ALİBAZ ÖNER
Pages
129–136
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The patient group also had lower IVV (p=0.004) and IVA (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: We evaluated right (RV) and left (LV) ventricle functions by tissue Doppler imaging (TDI) in patients with subclinical hypothyroidism (SH).
📊
Key Findings & Data:Study design: Twenty-seven patients (24 women, 3 men; mean age 35.4±11.4 years) with newly diagnosed SH and 22 age- and sex-matched healthy subjects (20 women, 2 men; mean age 34.8±8.6 years) were evaluated by standard echocardiography and TDI.
💡
Conclusion & Impact:The patient group also had lower IVV (p=0.004) and IVA (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: We evaluated right (RV) and left (LV) ventricle functions by tissue Doppler imaging (TDI) in patients with subclinical hypothyroidism (SH). Study design: Twenty-seven patients (24 women, 3 men; mean age 35.4±11.4 years) with newly diagnosed SH and 22 age- and sex-matched healthy subjects (20 women, 2 men; mean age 34.8±8.6 years) were evaluated by standard echocardiography and TDI. The diagnosis of SH was based on increased serum thyrotropin (TSH) level in the presence of normal free T3 and free T4 levels. The following TDI-derived parameters were measured: isovolumic myocardial acceleration (IVA), peak myocardial velocity during isovolumic contraction (IVV), peak systolic velocity during ejection period (S), and diastolic indices including peak early (E’) and late (A’) diastolic velocities, E’/A’ and E/E’ ratios, and myocardial performance index. Results: Compared to healthy controls, patients with SH had higher LV mitral A velocity (p=0.022), lower E/A ratio (p=0.021), lower E’ velocity (p=0.019), and higher E/E’ ratio (p=0.017), suggesting significant LV diastolic dysfunction. The patient group also had lower IVV (p=0.004) and IVA (p

Özet

Amaç: Subklinik hipotiroidi (SH) olan hastalarda sağ ve sol ventrikül fonksiyonları doku Doppler ekokardiyografi ile değerlendirildi. Çalışma planı: Çalışmada, SH tanısı yeni konmuş 27 hasta (24 kadın, 3 erkek; ort. yaş 35.4±11.4) ve yaş ve cinsiyet uyumlu 22 sağlıklı birey (20 kadın, 2 erkek; ort. yaş 34.8±8.6) konvansiyonel ve doku Doppler ekokardiyografi ile incelendi. Subklinik hipotiroidi, normal serbest T3 ve T4 düzeyleri yanında serum tirotropin (TSH) düzeyinin yüksekliği olarak tanımlandı. Doku Doppler ile incelenen parametreler şunlardı: sistolik akımlardan izovolümik miyokart hızlanması (IVA), izovolümik kontraksiyon sırasındaki zirve miyokart hızı (IVV), ejeksiyon fazı sırasındaki zirve sistolik hız (S); diyastolik parametrelerden erken (E’) ve geç (A’) diyastolik zirve akımlar, E’/A’ ve E/E’ oranları ve miyokart performans indeksi. Bulgular: Sağlıklı kişilerle karşılaştırıldığında, SH’li grupta sol ventrikülde ciddi derecede diyastolik fonksiyon bozukluğunu gösteren veriler elde edildi: yüksek mitral A hızı (p=0.022) ve E/E’ oranı (p=0.017); düşük E/A oranı (p=0.021) ve E’ hızı (p=0.019). Bu grupta anlamlı derecede düşük IVV (p=0.004) ve IVA (p

🔖

Cite This Article

USTA, M., ARSLANTAŞ, M. K., ÖNER, E., ERGÜNEY, M., YURDAKUL, S., ÖNER, F. A. (2022). Subklinik hipotiroidizmde ventrikül fonksiyonlarının doku doppler ekokardiyografi ile değerlendirilmesi. Türk Kardiyoloji Derneği Arşivi, Cilt: 39 - Sayı: 2, 129–136. https://ajindex.com/articles/633125

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med 2001;344:501-9
  2. Kahaly GJ, Dillmann WH. Thyroid hormone action in the heart. Endocr Rev 2005;26:704-28
  3. Kiss E, Brittsan AG, Edes I, Grupp IL, Grupp G, Kranias EG. Thyroid hormone-induced alterations in phospholamban- deficient mouse hearts. Circ Res 1998;83:608-13
  4. Fazio S, Palmieri EA, Lombardi G, Biondi B. Effects of thyroid hormone on the cardiovascular system. Recent Prog Horm Res 2004;59:31-50
  5. Osman F, Gammage MD, Franklyn JA. Thyroid disease and its treatment: short-term and long-term cardiovascularconsequences. Curr Opin Pharmacol 2001;1:626-31
  6. Biondi B, Fazio S, Palmieri EA, Carella C, Panza N, Cittadini A, et al. Left ventricular diastolic dysfunction in patients with subclinical hypothyroidism. J Clin Endocrinol Metab 1999;84:2064-7
  7. Biondi B, Palmieri EA, Lombardi G, Fazio S. Effects of subclinical thyroid dysfunction on the heart. Ann Intern Med 2002;137:904-14
  8. Akçakoyun M, Kaya H, Kargın R, Pala S, Emiroğlu Y, Esen Ö, et al. Abnormal left ventricular longitudinal functional reserve assessed by exercise pulsed wave tissue Doppler imaging in patients with subclinical hypothyroidism. J Clin Endocrinol Metab 2009;94:2979-83
  9. Zoncu S, Pigliaru F, Putzu C, Pisano L, Vargiu S, Deidda M, et al. Cardiac function in borderline hypothyroidism: a study by pulsed wave tissue Doppler imaging. Eur J Endocrinol 2005;152:527-33
  10. Yazıcı M, Görgülü S, Sertbaş Y, Erbilen E, Albayrak S, Yıldız O, et al. Effects of thyroxin therapy on cardiac function in patients with subclinical hypothyroidism: index of myocardial performance in the evaluation of left ventricular function. Int J Cardiol 2004;95:135-43
  11. Monzani F, Di Bello V, Caraccio N, Bertini A, Giorgi D, Giusti C, et al. Effect of levothyroxine on cardiac function and structure in subclinical hypothyroidism: a double blind, placebo-controlled study. J Clin Endocrinol Metab 2001;86:1110-5
  12. Hak AE, Pols HA, Visser TJ, Drexhage HA, Hofman A, Witteman JC. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med 2000;132:270-8
  13. Perk M, O’Neill BJ. The effect of thyroid hormone therapy on angiographic coronary artery disease progression. Can J Cardiol 1997;13:273-6
  14. Kukulski T, Hübbert L, Arnold M, Wranne B, Hatle L, Sutherland GR. Normal regional right ventricular function and its change wi