Journals / Türk Kardiyoloji Derneği Arşivi / 2012 / Cilt: 40 - Sayı: 6

Sildenafil akut koroner tromboza yol açar mı?

Does sildenafil contribute to acute coronary thrombosis?

Pages
536–539
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Coronary angioplasty and stenting was successfully performed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Sildenafil was the first oral compound to be approved for the treatment of erectile dysfunction.
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Key Findings & Data:It is a selective inhibitor of isoform 5 of phosphodiesterase, which is the enzyme responsible for the breakdown of 3 , 5 -cyclic guanosine mono-phosphate.
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Conclusion & Impact:Coronary angioplasty and stenting was successfully performed.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Sildenafil was the first oral compound to be approved for the treatment of erectile dysfunction. It is a selective inhibitor of isoform 5 of phosphodiesterase, which is the enzyme responsible for the breakdown of 3 , 5 -cyclic guanosine mono-phosphate. Sildenafil-associated myocardial infarction (MI) is rarely seen in patients without previous history of coronary artery disease. A 43-year-old man presented with sudden onset of chest pain. It was determined that his chest pain started after sildenafil intake. Findings consistent with acute anterior MI were observed on electrocardiography. Coronary angiography showed total occlusion of left anterior descending artery with thrombosis. Coronary angioplasty and stenting was successfully performed.

Özet

Sildenafil erektil fonksiyon bozukluğunun tedavisinde onaylanan oral yolla kullanılan ilk ajandır. Sildenafil 3-5 monosiklik guanizin monofosfatın yıkımından sorumlu olan 5-fosfodiesterazın selektif inhibitörüdür. Sildenafil ile ilişkili miyokart enfarktüsü (ME) daha öncesinde koroner arter hastalığı olmayan hastalarda oldukça nadirdir. Kırk üç yaşında erkek hasta ani başlayan göğüs ağrısı ile başvurdu. Göğüs ağrısının sildenafil alımı sonrası başladığı öğrenildi. Elektrokardiyografide akut anteriyor ME bulguları saptandı. Yapılan koroner anjiyografide sol ön inen arterin tam tıkalı ve tromboze olduğu görüldü. Koroner anjiyoplasti ve stent işlemi başarıyla uygulandı.

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Cite This Article

ÇAKAR, M. A., DOĞAN, E., TATLI, E., ALKAN, M. (2022). Sildenafil akut koroner tromboza yol açar mı?. Türk Kardiyoloji Derneği Arşivi, Cilt: 40 - Sayı: 6, 536–539. https://ajindex.com/articles/633092

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