Journals / Türk Kardiyoloji Derneği Arşivi / 2012 / Cilt: 40 - Sayı: 3

Koroner stent uygulanan ST yükselmesiz akut koroner sendromda geç dönem ölçülen long pentraxin-3 ün GRACE risk skoru ile ilişkisi

Long pentraxin-3 measured at late phase associated with GRACE risk scores in patients with non-ST elevation acute coronary syndrome and coronary stenting

Pages
205–212
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The serum PTX3 levels may provide impor- ant information for the early risk stratification of patients with ACS who underwent coronary stenting.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: We analyzed pentraxin 3 (PTX3) levels and he relation of PTX3 levels with GRACE risk scores in 39 patients with non-ST elevation acute coronary syndrome ACS) and stabile angina after stenting.
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Key Findings & Data:Study design: Seventeen patients with ACS and 22 pa- ients with stabile angina who underwent coronary stenting were included in the study.
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Conclusion & Impact:Conclusion: The serum PTX3 levels may provide impor- ant information for the early risk stratification of patients with ACS who underwent coronary stenting.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: We analyzed pentraxin 3 (PTX3) levels and he relation of PTX3 levels with GRACE risk scores in 39 patients with non-ST elevation acute coronary syndrome ACS) and stabile angina after stenting. Study design: Seventeen patients with ACS and 22 pa- ients with stabile angina who underwent coronary stenting were included in the study. PTX3 levels were measured se- ially at admission, at the 8th hour and at the 24th hour after stenting. Results: While diabetes and hypertension were more fre- quent in the stabile angina group, leukocyte counts were significantly higher in the ACS group. PTX3 levels mea- sured at the 8th hour were significantly higher in the ACS group compared to the stabile angina group (p=0.003). Strong correlations were observed between 24th hour PTX3 levels and GRACE scores calculated for risk of death and death/MI at admission (in-hospital/to 6 months), and for isk of death/MI at discharge to 6 months (R=0.571, p=0.01, R=0.564, p=0.01; R=0.558, p=0.02, R=0.512, p=0.03; R=0.653, p=0.004, respectively). Conclusion: The serum PTX3 levels may provide impor- ant information for the early risk stratification of patients with ACS who underwent coronary stenting.

Özet

Amaç: Kararlı anjina ve ST yükselmesiz akut koroner sendrom (AKS) tanısıyla perkütan koroner girişim (PKG) yapılmış 39 hastada ardışık ölçülen pentraxin-3 (PTX3) düzeyleri ve bu düzeylerin GRACE risk skoru ile ilişkisi incelendi. Çalışma planı: Çalışmaya perkütan koroner stent takılan ST yükselmesiz AKS tanılı 17, kararlı anjina tanılı 22 olgu alındı. Tüm hastalarda girişim öncesi, girişim sonrası 8. ve 24. saatte PTX3 ölçümü için kan örnekleri alındı. Bulgular: Kararlı anjinalı grupta diabetes mellitus ve hipertansiyonlu olgu sayısı anlamlı olarak daha yüksek iken, AKS grubunda lökosit sayısı anlamlı olarak daha yüksek saptandı. Sekizinci saat ölçülen PTX3 düzeyleri anlamlı olarak AKS grubunda daha yüksekti (p=0.003). AKSli olgularda 24. saat PTX3 düzeyleri ile GRACE başvuru hastane içi ve 6 ay ölüm-kardiyak ölüm-ME ve GRACE taburculuk kardiyak ölüm-ME risk oranları arasında güçlü korelasyon saptandı (sırasıyla, p=0.02, R: 0.558; p=0.03, R=0,512; p=0.01, R=0,571; p=0.01, R=0.564; p=0.004, R=0.653). Sonuç: Serum PTX3 düzeyleri koroner stent takılan AKSli olgularda erken risk sınıflaması açısından önemli bilgiler verebilir.

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Cite This Article

TAMER, G. S., KIRILMAZ, B., ERCAN, E., TENGİZ, İ., YILDIZ, H., SAYGI, S., ALİOĞLU, E., TÜZÜN, N., TÜRK, U. Ö. (2022). Koroner stent uygulanan ST yükselmesiz akut koroner sendromda geç dönem ölçülen long pentraxin-3 ün GRACE risk skoru ile ilişkisi. Türk Kardiyoloji Derneği Arşivi, Cilt: 40 - Sayı: 3, 205–212. https://ajindex.com/articles/632985

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