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Journals / Türk Kardiyoloji Derneği Arşivi / 2013 / Cilt: 41 - Sayı: 1

Gen polimorfizmi olan bir hastada tekrarlayan pacemaker elektrodu trombüsü: Trombolitik ilaçla tedavi edilen nadir bir olgu

Recurrent pacemaker lead thrombosis in a patient with gene polymorphism: A rare case treated with thrombolytic therapy

Selma DÜZENLİ
Serkan ÖZTÜRK
Selim S. AYHAN
Mehmet Fatih ÖZLÜ
Pages
64–67
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Genetic tests revealed that the patient was a heterozygous carrier of the methylenetetrahydrofolate reductase (MTHFR) gene mutation.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Pacemaker (PM)-related thrombosis is an in- frequent complication of pacing.
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Key Findings & Data:We present the case of a 58-year-old man with heart failure and atrial fibrillation who had recurrent episodes of PM lead thrombosis while under- going anticoagulation therapy.
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Conclusion & Impact:Genetic tests revealed that the patient was a heterozygous carrier of the methylenetetrahydrofolate reductase (MTHFR) gene mutation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Pacemaker (PM)-related thrombosis is an in- frequent complication of pacing. We present the case of a 58-year-old man with heart failure and atrial fibrillation who had recurrent episodes of PM lead thrombosis while under- going anticoagulation therapy. The patient was admitted to the hospital with complaints of dyspnea and palpitation. Echocardiography revealed normal right ventricular dimen- sions and an enlarged left ventricle with poor contractility and an ejection fraction of 20%. Transesophageal echocar- diography demonstrated a large, mobile thrombus in the right atrium that was attached to the PM lead. The patient was successfully treated with a thrombolytic agent. Genetic tests revealed that the patient was a heterozygous carrier of the methylenetetrahydrofolate reductase (MTHFR) gene mutation.

Özet

Pacemaker (PM) ile ilişkili trombüs, PM implantasyonun nadir görülen komplikasyonlarından biridir. Bu yazıda, kalp yetersizliği ve atriyum fibrilasyonu tanılarıyla takip edilen ve antikoagülan tedavi altındayken tekrarlayan PM elektrodu trombüsü gelişen 58 yaşında erkek hasta sunuldu. Nefes darlığı ve çarpıntı şikayeti ile hastaneye kabul edilen hastanın ekokardiyografisinde genişlemiş ve kasılması azalmış sol ventrikül (EF %20) ile normal sınırlarda sağ ventrikül görüldü. Ayrıca PM elektroduna tutunan sağ atriyum trombüsü saptandı. Transözefajiyal ekokardiyografi incelemesinde, sağ atriyumda PM elektroduna tutunan büyük ve hareketli trombüs gösterildi. Hasta, trombolitik ajan ile başarılı olarak tedavi edildi. Genetik testlerde hastanın heterozigot metilentetrahidrofolat redüktaz (MTHFR) taşıyıcısı olduğu saptandı.

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Cite This Article

DÜZENLİ, S., ÖZTÜRK, S., AYHAN, S. S., ÖZLÜ, M. F. (2022). Gen polimorfizmi olan bir hastada tekrarlayan pacemaker elektrodu trombüsü: Trombolitik ilaçla tedavi edilen nadir bir olgu. Türk Kardiyoloji Derneği Arşivi, Cilt: 41 - Sayı: 1, 64–67. https://ajindex.com/articles/632937

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