Journals / Türk Kardiyoloji Derneği Arşivi / 2013 / Cilt: 41 - Sayı: 4

Akut koroner sendromlu hastalarda serum gama-glutamiltransferaz düzeyi ve aterosklerozun yaygınlığı

Serum gamma-glutamyltransferase and the burden of atherosclerosis in patients with acute coronary syndrome

Pages
275–281
Publication Date
2022-11-05
DOI
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Correlation analysis revealed that the level of GGT was significantly associated with Gensini and Syntax scores, number of diseased vessels, and the number of critical lesions (r=0.378 p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: We evaluated the relationship between serum gamma-glutamyltransferase (GGT) levels and the burden of atherosclerosis in patients with acute coronary syndrome (ACS).
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Key Findings & Data:Study design: This study involved 180 patients (139 male, 41 female; mean age 63±11 years) with the diagnosis of ACS (non- ST elevation myocardial infarction and unstable angina) who underwent coronary angiography on the first day after hospital admission.
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Conclusion & Impact:Correlation analysis revealed that the level of GGT was significantly associated with Gensini and Syntax scores, number of diseased vessels, and the number of critical lesions (r=0.378 p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: We evaluated the relationship between serum gamma-glutamyltransferase (GGT) levels and the burden of atherosclerosis in patients with acute coronary syndrome (ACS). Study design: This study involved 180 patients (139 male, 41 female; mean age 63±11 years) with the diagnosis of ACS (non- ST elevation myocardial infarction and unstable angina) who underwent coronary angiography on the first day after hospital admission. The burden of atherosclerosis was assessed by the number of involved vessels, and the Gensini and Syntax scores. Serum GGT levels were measured by enzymatic caloric test. Results: Patients with high Syntax scores (≥33) were more frequently diabetic, hypertensive, and had higher GGT and creatinine levels compared to the patients with low Syntax scores (≤23). Similarly, patients with ≥3 diseased vessels were more frequently diabetic, hypertensive, and smokers. In addition, these patients were older and had higher serum glucose, urea and GGT levels. Correlation analysis revealed that the level of GGT was significantly associated with Gensini and Syntax scores, number of diseased vessels, and the number of critical lesions (r=0.378 p

Özet

Amaç: Bu çalışmada, akut koroner sendromlu (AKS) hastalarda serum gama-glutamiltransferaz (GGT) düzeyi ile ateroskleroz yükü arasındaki ilişki araştırıldı. Çalışma planı: Çalışmaya AKS (ST yükselmesi olmayan miyokart enfarktüsü veya kararsız anjina pektoris) tanısı ile kliniğe başvuran ve kabul edildikten sonraki ilk gün içinde koroner anjiyografi yapılan 180 hasta (139 erkek, 41 kadın; ort. yaş 63±11 yıl) alındı. Ateroskleroz yükü tutulan damar sayısı, Gensini skoru ve Syntax skoru ile değerlendirildi. Serum GGT düzeyi enzimatik kalorimetrik test ile ölçüldü. Bulgular: Yüksek Syntax skoru olan hastalarda (≥33), düşük Syntax skoru (≤22) olan grup ile karşılaştırıldığında diyabetli ve hipertansiyonlu hasta oranı, serum GGT ve kreatinin düzeyleri daha yüksek bulundu. Benzer şekilde, ≥3 damar hastalığı olanlarda diyabetli, hipertansiyonlu ve sigara içen hasta oranı ile yaş, serum glukoz, üre ve GGT düzeyleri daha yüksekti. Korelasyon analizinde serum GGT düzeyleri, Gensini ve Syntax skorları ile, hasta damar sayısı ve kritik lezyon sayısı ile anlamlı ilişkili bulundu (sırasıyla, r=0.378 p

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Cite This Article

OĞUZHAN, A., DURAN, M., TOPSAKAL, R., ERYOL, N. K., YILMAZ, Y., ARINÇ, H., ERGİN, A., KAYA, M. G., GÜNEBAKMAZ, Ö., UYSAL, O. K. (2022). Akut koroner sendromlu hastalarda serum gama-glutamiltransferaz düzeyi ve aterosklerozun yaygınlığı. Türk Kardiyoloji Derneği Arşivi, Cilt: 41 - Sayı: 4, 275–281. https://ajindex.com/articles/632917

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