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Journals / Türk Kardiyoloji Derneği Arşivi / 2013 / Cilt: 41 - Sayı: 7

Miyokart enfarktüsü sonrası geç dönemde plazma matriks metalloproteinaz-8 seviyelerinin sol ventrikül hacimleri ve ejeksiyon fraksiyonu ile ilişkisi

Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fraction

Filiz KIZILIRMAK
Ayhan ERKOL
Alev KILICGEDİK
Selçuk PALA
Vecih ODUNCU
Cevat KIRMA
Ahmet GÜLER
Can Yüce KARABAY
Pages
617–624
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: The MMP-8 levels were significantly higher in post- MI patients [median 3.88 ng/ml, interquartile range (1.88- 6.43) vs. 0.67 ng/ml (0.34-2.47); p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Enhanced matrix metalloproteinase-8 (MMP-8) activity in the early post-myocardial infarction (MI) period has been related to early remodeling.
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Key Findings & Data:However, it has been dem- onstrated that plasma MMP-8 level has a biphasic profile, and the relation between the late plasma levels and remodeling is unclear.
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Conclusion & Impact:Results: The MMP-8 levels were significantly higher in post- MI patients [median 3.88 ng/ml, interquartile range (1.88- 6.43) vs. 0.67 ng/ml (0.34-2.47); p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Enhanced matrix metalloproteinase-8 (MMP-8) activity in the early post-myocardial infarction (MI) period has been related to early remodeling. However, it has been dem- onstrated that plasma MMP-8 level has a biphasic profile, and the relation between the late plasma levels and remodeling is unclear. We evaluated the plasma MMP-8 levels and its cor- relates 20±3 months after acute MI. Study design: 58 post-MI patients and 26 control subjects underwent quantitative single-photon emission computed tomography (SPECT) and echocardiography. The plasma MMP-8 levels were measured and its correlates were inves- tigated. Results: The MMP-8 levels were significantly higher in post- MI patients [median 3.88 ng/ml, interquartile range (1.88- 6.43) vs. 0.67 ng/ml (0.34-2.47); p

Özet

Amaç: Miyokart enfarktüsü (ME) sonrası erken dönemde artmış matriks metalloproteinaz-8 (MMP-8) aktivitesinin erken yeniden şekillenme ile ilişkisi olduğu bilinmektedir. Ancak MMP-8in bifazik bir profile sahip olduğu gösterilmiştir ve geç dönem plazma seviyeleri ile yeniden şekillenme arasındaki ilişki net değildir. Çalışmamızda MEnin 20±3 ay sonrasında plazma MMP-8 seviyelerini ve klinik parametrelerle olan ilişkisini inceledik.Çalışma planı: Miyokart enfaktüsü geçirmiş 58 hasta ve 26 bireylik kontrol grubuna kantitatif tek-foton emisyon bilgisayarlı tomografi (SPECT) ve ekokardiyografi yapıldı. Plazma MMP-8 seviyeleri ölçüldü ve korelasyonları incelendi.Bulgular: Plazma MMP-8 seviyeleri ME geçirmişlerde anlamlı olarak daha yüksek idi [medyan 3.88 ng/ml, çeyreklerarası aralık (1.88-6.43) ve 0.67 ng/ml (0.34-2.47); p

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Cite This Article

KIZILIRMAK, F., ERKOL, A., KILICGEDİK, A., PALA, S., ODUNCU, V., KIRMA, C., GÜLER, A., KARABAY, C. Y. (2022). Miyokart enfarktüsü sonrası geç dönemde plazma matriks metalloproteinaz-8 seviyelerinin sol ventrikül hacimleri ve ejeksiyon fraksiyonu ile ilişkisi. Türk Kardiyoloji Derneği Arşivi, Cilt: 41 - Sayı: 7, 617–624. https://ajindex.com/articles/632876

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References (11)

  1. Cohn JN, Ferrari R, Sharpe N. Cardiac remodeling-concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol 2000;35:569-82
  2. Wilson EM, Gunasinghe HR, Coker ML, Sprunger P, Lee- Jackson D, Bozkurt B, et al. Plasma matrix metalloproteinase and inhibitor profiles in patients with heart failure. J Card Fail 2002;8:390-8
  3. Chapman RE, Spinale FG. Extracellular protease activation and unraveling of the myocardial interstitium: critical steps toward clinical applications. Am J Physiol Heart Circ Physiol 2004;286:H1-H10
  4. Spinale FG. Matrix metalloproteinases: regulation and dysregulation in the failing heart. Circ Res 2002;90:520-30
  5. Kelly D, Cockerill G, Ng LL, Thompson M, Khan S, Samani NJ, et al. Plasma matrix metalloproteinase-9 and left ventricular remodelling after acute myocardial infarction in man: a prospective cohort study. Eur Heart J 2007;28:711-8. 6. van den Borne SW, Cleutjens JP, Hanemaaijer R, Creemers EE, Smits JF, Daemen MJ, et al. Increased matrix metalloproteinase- 8 and -9 activity in patients with infarct rupture after myocardial infarction. Cardiovasc Pathol 2009;18:37-43
  6. Webb CS, Bonnema DD, Ahmed SH, Leonardi AH, McClure CD, Clark LL, et al. Specific temporal profile of matrix metalloproteinase release occurs in patients after myocardial infarction: relation to left ventricular remodeling. Circulation 2006;114:1020-7
  7. Gottdiener JS, Bednarz J, Devereux R, Gardin J, Klein A, Manning WJ, et al. American Society of Echocardiography recommendations for use of echocardiography in clinical trials. J Am Soc Echocardiogr 2004;17:1086-119
  8. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 1990;81:1161-72
  9. Vanhoutte D, Schellings M, Pinto Y, Heymans S. Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: a temporal and spatial window. Cardiovasc Res 2006;69:604-13
  10. Yan AT, Yan RT, Spinale FG, Afzal R, Gunasinghe HR, Arnold M, et al. Plasma matrix metalloproteinase-9 level is correlated with left ventricular volumes and ejection fraction in patients with heart failure. J Card Fail 2006;12:514-9
  11. Bradham WS, Gunasinghe H, Holder JR, Multani M, Killip D, Anderson M, et al. Release of matrix metalloproteinases following alcohol septal ablation in hypertrophic obstructive car