Journals / Türk Kardiyoloji Derneği Arşivi / 2013 / Cilt: 41 - Sayı: 5

Diyabeti olmayan akut koroner sendromlu hastalarda HbA1c düzeyi ile koroner arter hastalığı ciddiyeti arasındaki ilişki

Relationship between HbA1c levels and coronary artery severity in nondiabetic acute coronary syndrome patients

Pages
389–395
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In our study, no significant relationship could be determined between the Gensini score and HbA1C, fasting and postprandial blood glucose levels, lipid profile, and hs- CRP levels in patients with nondiabetic ACSs.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: In this study, we aimed to investigate the relation- ship between HbA1c levels and the severity of coronary ar- tery stenosis in patients with acute coronary syndrome (ACS) without diabetes mellitus.
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Key Findings & Data:Study design: In this study, we included 65 patients (11 females, mean age: 57±11.42 years; 54 males, mean age: 54.56±8.51 years) who were diagnosed as acute myocardial infarction without diabetes mellitus.
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Conclusion & Impact:Conclusion: In our study, no significant relationship could be determined between the Gensini score and HbA1C, fasting and postprandial blood glucose levels, lipid profile, and hs- CRP levels in patients with nondiabetic ACSs.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: In this study, we aimed to investigate the relation- ship between HbA1c levels and the severity of coronary ar- tery stenosis in patients with acute coronary syndrome (ACS) without diabetes mellitus. Study design: In this study, we included 65 patients (11 females, mean age: 57±11.42 years; 54 males, mean age: 54.56±8.51 years) who were diagnosed as acute myocardial infarction without diabetes mellitus. During hospitalization, fasting blood glucose, postprandial blood glucose and HbA1C were measured in each patient. Gensini score was used to assess the severity of coronary artery disease. Results: Twenty patients (30.8%) had hypertension, 15 (23.1%) had impaired fasting glucose, 10 (15.3%) had combined im- paired fasting and postprandial glucose, 28 had a low HDL cho- lesterol (45%), and 30 (46%) had abdominal obesity. Coronary angiography revealed one-vessel disease in 13 patients (20%), and two- and three-vessel disease in 52 patients (80%). There were no significant differences in terms of high-sensitive C-re- active protein (hs-CRP), total cholesterol, fasting glucose, and postprandial glucose (0.068, 0.974, 0.178, 0.677, respectively). There was no significant relation between the Gensini score and HbA1c levels (p=0.299), but there was a significant relation between the Gensini score and obesity (p=0.024). Conclusion: In our study, no significant relationship could be determined between the Gensini score and HbA1C, fasting and postprandial blood glucose levels, lipid profile, and hs- CRP levels in patients with nondiabetic ACSs.

Özet

Amaç: Bu çalışmada, diyabeti olmayan akut koroner sendromlu (AKS) hastalarda koroner arter hastalığının ciddiyeti ile serum HbA1c düzeyleri arasındaki ilişkiyi araştırmaya çalıştık.Çalışma planı:Çalışmaya diabetes mellitusu olmayan akut miyokart enfarktüsü tanısı konan toplam 65 hasta (11 kadın, ortalama yaş 57±11.42 yıl; 54 erkek, ortalama yaş 54.56±8.51 yıl) alındı. Hastanede yatışları sırasında bütün hastalarda açlık ve tokluk kan şekeri, HbA1c ölçümü yapıldı. Koroner arter hastalığının ciddiyeti Gensini skorlaması ile değerlendirildi.Bulgular: Hastaların 20sinde (%30.8) hipertansiyon, 15inde (%23.1) bozulmuş açlık glukozu, 10unda (%15.3) birlikte bozulmuş açlık ve tokluk glukozu, 28inde (%45) HDL kolesterol ve 30unda (%46) abdominal obezite vardı. Koroner anjiyografiyle tek damar hastalığı hastaların 13ünde (%20), iki ve üç damar hastalığı 52sinde (%80) tespit edildi. Yüksek duyarlıklı C-reaktif protein (hs-CRP), total kolesterol, açlık kan şekeri ve tokluk kan şekeri açısından anlamlı farklılık yoktu (sırasıyla, 0.068, 0.974, 0.178, 0.977). Gensini skoru ile HbA1c düzeyleri arasında anlamlı korelasyon saptanmadı (p=0.299), fakat Gensini skoru ve obezite arasında anlamlı bir ilişki vardı (p=0.024).Sonuç: Bu çalışmada, diyabeti olmayan AKSli hastalarda anjiyografik Gensini skoru ile HbA1c düzeyi, serum açlık ve tokluk glukoz düzeyleri, lipit profili ve hs-CRP düzeyleri arasında anlamlı bir ilişki saptanmadı.

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Cite This Article

AKDEMİR, R., YETER, E., KILIÇ, H., ERTEM, A. G., BAĞBANCI, H. (2022). Diyabeti olmayan akut koroner sendromlu hastalarda HbA1c düzeyi ile koroner arter hastalığı ciddiyeti arasındaki ilişki. Türk Kardiyoloji Derneği Arşivi, Cilt: 41 - Sayı: 5, 389–395. https://ajindex.com/articles/632872

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