Journals / Türk Kardiyoloji Derneği Arşivi / 2014 / Cilt: 42 - Sayı: 6

ST yükselmeli akut miyokart enfarktüslü hastalarda ürik asit düzeyi ile erken dönem kalp yetersizliği ve mortalite arasındaki ilişki

The association between serum uric acid level and heart failure and mortality in the early period of ST-elevation acute myocardial infarction

Pages
501–508
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: This study showed that a high serum UA level is an independent predictor of cardiovascular mortality and mor- bidity during the in-hospital period of STEMI.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Uric acid (UA) is a strong marker of cardiovascular disease.
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Key Findings & Data:Study design: This retrospective study included 586 consecu- tive patients with ST-elevated myocardial infarction (STEMI) who were admitted to the hospital between March 2010 and February 2012.
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Conclusion & Impact:Conclusion: This study showed that a high serum UA level is an independent predictor of cardiovascular mortality and mor- bidity during the in-hospital period of STEMI.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: Uric acid (UA) is a strong marker of cardiovascular disease. Therefore, we aimed to determine the relationship be- tween serum UA levels and cardiovascular events in patients in the early period of their acute myocardial infarction. Study design: This retrospective study included 586 consecu- tive patients with ST-elevated myocardial infarction (STEMI) who were admitted to the hospital between March 2010 and February 2012. The study population was divided into two groups; the first group included hyperuricemic patients (n=107; uric acid level >6 mg/dl in women and >7 mg/dl in men), and the second group included patients with normal UA level (n=479). Multivariate analysis was used to demonstrate the predictive value of UA levels in groups. Results: Patients in the hyperuricemic group were older (me- dian 66 years vs. 60 years, p=0.001), and the ratio of female patients was higher (35.5% vs. 16.9%, p=0.001). Patients with hyperuricemia had a significantly higher incidence of in-hospi- tal cardiovascular mortality than the normal group (15.9% vs. 3.1%, p6 hours and hy- peruricemia (hazard ratio (HR): 1.83, 95% confidence interval: 1.02-3.27; p=0.041) were found to be independent predictors of advanced heart failure. Hyperuricemia was found to be an independent predictor of in-hospital cardiovascular mortality in multivariate analyses (HR: 5.32, 95% confidence interval: 2.46- 11.49; p=0.001). Conclusion: This study showed that a high serum UA level is an independent predictor of cardiovascular mortality and mor- bidity during the in-hospital period of STEMI.

Özet

Amaç: Ürik asit (ÜA) kalp damar hastalığı için güçlü bir belirteçtir. Bu çalışmada akut miyokart enfarktüsü geçiren hastalarda serum ÜA düzeyi ile kardiyovasküler olaylar arasındaki ilişkiyi araştırmayı amaçladık.Çalışma planı: Koroner yoğun bakım ünitesinde Mart-2010 ile Şubat-2012 tarihleri arasında ST yükselmeli miyokart enfarktüsü (STYME) tanısı ile takip edilen 586 hasta, bu geriye dönük çalışmaya alındı. Başvuru sırasında bakılan ÜA düzeyine göre hastalar iki gruba ayrıldı. Hiperürisemik grup (n=107): ÜA düzeyi kadınlarda >6 mg/dl ve erkeklerde >7 mg/dl; normal grup (n=479): ÜA düzeyi belirtilen değerlerin altında olanlar. Hiperüriseminin kalp damar hastalığı mortalitesini öngörmedeki değeri çok-değişkenli analiz ile değerlendirildi.Bulgular: Hiperürisemik grup normal grupla karşılaştırıldığında daha yaşlı (ortanca 66 yaş ve 60 yaş, p=0.001) ve kadın cinsiyet oranı daha fazlaydı (%35.5 ve %16.9, p=0.001). Hiperürisemi grubunda, normal gruba göre kalp damar hastalığına bağlı ölüm daha yüksek oranda görüldü (%15.9 ve %3.1, p

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Cite This Article

BARUTÇU, A., GAZİ, E., KURT, T., TEMİZ, A., GÜNGÖR, Ö., ÖZCAN, S., BEKLER, A., YENER, A. Ü., GAZİ, S., ALTUN, B. (2022). ST yükselmeli akut miyokart enfarktüslü hastalarda ürik asit düzeyi ile erken dönem kalp yetersizliği ve mortalite arasındaki ilişki. Türk Kardiyoloji Derneği Arşivi, Cilt: 42 - Sayı: 6, 501–508. https://ajindex.com/articles/632856

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