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Journals / Türk Kardiyoloji Derneği Arşivi / 2014 / Cilt: 42 - Sayı: 5

Koroner arter baypas cerrahisi sonrası gelişen atriyum fibrilasyonu patogenezinde iskemi reperfüzyon hasarı sonucu oluşan oksidatif stresin rolü

The effect of oxidative stress related with ischemia-reperfusion damage on the pathogenesis of atrial fibrillation developing after coronary artery bypass graft surgery

Ayşem KAYA
Okay ABACI
Ümit Yaşar SİNAN
Cenk Eray YILDIZ
Veysel OKTAY
Cüneyt KOCAŞ
Zerrin YİĞİT
Ali Can HATEMİ
Gürkan ÇETİN
Ahmet YILDIZ
Onur BAYDAR
Pages
419–425
Publication Date
2022-11-05
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Results: A comparison of preoperative demographic, labora- tory, echocardiographic, and postoperative clinical characteris- tics between the two groups showed that patients in Group 1 were significantly older (65.6±7.20 vs. 59.6±9.07, p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: We aimed to investigate the role of oxidative stress related with ischemia- reperfusion damage on the patho- genesis of atrial fibrillation (AF) developing after coronary artery bypass graft (CABG) surgery.Study design: In our prospective, single-center study, 118 pa- tients who underwent elective isolated on-pump CABG surgery were included.
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Key Findings & Data:Patients were divided into two groups according to the development of postoperative atrial fibrillation (POAF) as Group 1: Patients who developed POAF, and Group 2: Patients who remained in sinus rhythm.
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Conclusion & Impact:Results: A comparison of preoperative demographic, labora- tory, echocardiographic, and postoperative clinical characteris- tics between the two groups showed that patients in Group 1 were significantly older (65.6±7.20 vs. 59.6±9.07, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: We aimed to investigate the role of oxidative stress related with ischemia- reperfusion damage on the patho- genesis of atrial fibrillation (AF) developing after coronary artery bypass graft (CABG) surgery.Study design: In our prospective, single-center study, 118 pa- tients who underwent elective isolated on-pump CABG surgery were included. Patients were divided into two groups according to the development of postoperative atrial fibrillation (POAF) as Group 1: Patients who developed POAF, and Group 2: Patients who remained in sinus rhythm. In addition to preoperative de- mographic, laboratory, echocardiographic, intraoperative, and postoperative clinical characteristics, levels of plasma total oxidative status (TOS) after placement and removal of aortic cross clamp (ACC) were compared between the two groups. Predictors of POAF were also investigated by multivariate lo- gistic regression analysis. Results: A comparison of preoperative demographic, labora- tory, echocardiographic, and postoperative clinical characteris- tics between the two groups showed that patients in Group 1 were significantly older (65.6±7.20 vs. 59.6±9.07, p

Özet

Amaç: Çalışmamızda koroner arter bapas cerrahisi (KABC) sonrası gelişen atriyum fibrilasyonu (AF) patogenezinde iskemi reperfüzyon hasarıyla (İRH) ilişkili oksidatif stresin rolünü araştırdık.Çalışma planı: Çalışmaya elektif koşullarda pompa kullanılarak ve tek başına KABC uygulanan 118 hasta dahil edildi. Hastalar ameliyat sonrası atriyum fibrilasyonu (POAF) gelişimine göre iki gruba ayrıldı. (Grup 1: POAF gelişen hastalar, Grup 2: Sinüs ritminde kalan hastalar). Her iki grup ameliyat öncesi, ameliyat sırasında ve ameliyat sonrasındaki klinik özellikler ile aort kros klemp (AKK) yerleştirilmesi ve uzaklaştırılması sonrası plazma toplam oksidatif durum (TOD) değerleri açısından karşılaştırıldı. POAF öngördürücüleri çok değişkenli lojistik regresyon analiziyle belirlendi.Bulgular: Her iki grup arasında ameliyat öncesi, sonrası ve ameliyat sırasındaki klinik özellikler açısından yapılan karşılaştırmada grup 1deki hastaların grup 2deki hastalara oranla daha ileri yaşta olduğu (65.6±7.20 ve 59.6±9.07, p

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Cite This Article

KAYA, A., ABACI, O., SİNAN, Ü. Y., YILDIZ, C. E., OKTAY, V., KOCAŞ, C., YİĞİT, Z., HATEMİ, A. C., ÇETİN, G., YILDIZ, A., BAYDAR, O. (2022). Koroner arter baypas cerrahisi sonrası gelişen atriyum fibrilasyonu patogenezinde iskemi reperfüzyon hasarı sonucu oluşan oksidatif stresin rolü. Türk Kardiyoloji Derneği Arşivi, Cilt: 42 - Sayı: 5, 419–425. https://ajindex.com/articles/632744

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References (6)

  1. Crystal E, Garfinkle MS, Connolly SS, Ginger TT, Sleik K, Yusuf SS. Interventions for preventing post-operative atrial fibrillation in patients undergoing heart surgery. Cochrane Database Syst Rev 2004;4:CD003611
  2. Elahi MM, Flatman S, Matata BM. Tracing the origins of postoperative atrial fibrillation: the concept of oxidative stress-mediated myocardial injury phenomenon. Eur J Cardiovasc Prev Rehabil 2008;15:735-41. CrossRef 3. Korantzopoulos P, Kolettis T, Siogas K, Goudevenos J. Atrial fibrillation and electrical remodeling: the potential role of inflammation and oxidative stress. Med Sci Monit 2003;9:RA225-9
  3. Oral H. Post-operative atrial fibrillation and oxidative stress: a novel causal mechanism or another biochemical epiphenomenon? J Am Coll Cardiol 2008;51:75-6. CrossRef 5. Davis EM, Packard KA, Hilleman DE. Pharmacologic prophylaxis of postoperative atrial fibrillation in patients undergoing cardiac surgery: beyond beta-blockers. Pharmacotherapy 2010;30:749, 274e-318e
  4. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005;38:1103-11. CrossRef 7. Ben Ahmed H, Chelli M, Selmi K, Fazaa S, Mokaddem A, Ben Ameur Y, et al. Atrial fibrillation following coronary artery bypass grafting: predictors and mid- term outcome. [Article in French] Tunis Med 2012;90:888-92. [Abstract] 8. Jakubová M, Mitro P, Stančák B, Sabol F, Kolesár A, Cisarik P, et al. The occurrence of postoperative atrial fibrillation according to different surgical settings in cardiac surgery patients. Interact Cardiovasc Thorac Surg 2012;15:1007-12
  5. Youn JY, Zhang J, Zhang Y, Chen H, Liu D, Ping P, Weiss JN, Cai H. Oxidative stress in atrial fibrillation: an emerging role of NADPH oxidase. J Mol Cell Cardiol 2013;62:72-9. CrossRef 10. Van Wagoner DR. Oxidative stress and inflammation in atrial fibrillation: role in pathogenesis and potential as a therapeutic target. J Cardiovasc Pharmacol 2008;52:306-13. CrossRef 11. Biglioli P, Cannata A, Alamanni F, Naliato M, Porqueddu M, Zanobini M, et al. Biological effects of off-pump vs. on-pump coronary artery surgery: focus on inflammation, hemostasis and oxidative stress. Eur J Cardiothorac Surg 2003;24:260-9
  6. Yeum KJ, Russell RM, Krinsky NI, Aldini G. Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma. Arch Biochem Biophys 2004;430:97-103. CrossRef 13. De Vecchi E, Pala MG, Di Credico G, Agape V, Paolini G, Bonini PA, et al. Relation bet