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Journals / Türk Kardiyoloji Derneği Arşivi / 2015 / Cilt: 43 - Sayı: 4

Obstrüktif uyku apne sendromlu hastalarda serum YKL 40/kitinaz 3 benzeri protein 1 düzeyi ateroskleroz gelişiminin bağımsız bir öngörücüsüdür

Serum YKL 40/chitinase 3 like protein 1 level is an independent predictor of atherosclerosis development in patients with obstructive sleep apnea syndrome

Taha Abdulkadir ÇOBAN
Gökhan CEYHUN
Edhem ÜNVER
Mutlu BÜYÜKLÜ
Ergun TOPAL
Tülay KIVANÇ
Hüsnü DEĞİRMENCİ
Hikmet HAMUR
Murat GÜNAY
Eftal Murat BAKIRCI
Pages
333–339
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CIMTwas strongly correlated with serum YKL 40 levels (r=0.694,p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The inflammatory process plays an important rolein the development of cardiovascular complications in patientswith obstructive sleep apnea syndrome (OSAS).
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Key Findings & Data:YKL-40/chitin- ase 3 like protein 1 is a novel biomarker of systemic inflamma- tion.
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Conclusion & Impact:CIMTwas strongly correlated with serum YKL 40 levels (r=0.694,p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The inflammatory process plays an important rolein the development of cardiovascular complications in patientswith obstructive sleep apnea syndrome (OSAS). YKL-40/chitin- ase 3 like protein 1 is a novel biomarker of systemic inflamma- tion. This study aimed to investigate whether carotid intima-me- dia thickness (CIMT), a useful marker for early atherosclerosis,is associated with serum YKL 40/chitinase 3 like protein 1 lev- els in patients with normotensive and nondiabetic OSAS. Methods: The study included 40 OSAS patients and 40 age-sex- and body mass index-matched healthy controls. SerumYKL 40 levels were detected by enzyme-linked immunosor- bent assay. CIMT was measured by B-mode ultrasound. Results: The patients with OSAS had significantly increasedCIMT and higher YKL 40 and high sensitivity C-reactiveprotein (hsCRP) levels than those of the controls. CIMTwas strongly correlated with serum YKL 40 levels (r=0.694,p

Özet

Amaç: Enflamatuvar süreç obstrüktif uyku apne sendromu(OUAS) bulunan hastalarda kardiyovasküler komplikasyonla- rın gelişmesinde önemli bir rol oynar. YKL 40/kitinaz 3 benzeriprotein 1 sistemik enflamasyonun güncel bir belirtecidir. Bu ça- lışmada, erken ateroskleroz için faydalı bir belirteç olan karotisintima medya kalınlığının (KİMK) diyabeti olmayan normotansifOUASli hastalarda serum YKL 40/Kitinaz 3 benzeri protein 1düzeyleri ile ilişkisi araştırıldı. Yöntemler: Çalışmaya OUASli 40 hasta ile yaş, cinsiyet vebeden kütle indeksi açısından eşleştirilmiş 40 sağlıklı kontrolalındı. Serum YKL 40 düzeyleri enzim bağlı immünosorbentölçüm yöntemi ile belirlendi. KİMK, B-mod ultrason ile ölçüldü. Bulgular: OUASli hastalar, kontrole göre önemli ölçüde artmışKİMK ve daha yüksek YKL 40 ve yüksek duyarlıklı C-reaktifprotein (hsCRP) düzeylerine sahipti. KİMK; serum YKL 40düzeyleri (r=0.694, p

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Cite This Article

ÇOBAN, T. A., CEYHUN, G., ÜNVER, E., BÜYÜKLÜ, M., TOPAL, E., KIVANÇ, T., DEĞİRMENCİ, H., HAMUR, H., GÜNAY, M., BAKIRCI, E. M. (2022). Obstrüktif uyku apne sendromlu hastalarda serum YKL 40/kitinaz 3 benzeri protein 1 düzeyi ateroskleroz gelişiminin bağımsız bir öngörücüsüdür. Türk Kardiyoloji Derneği Arşivi, Cilt: 43 - Sayı: 4, 333–339. https://ajindex.com/articles/632656

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