SavedAdd your journal

Journals / Türk Kardiyoloji Derneği Arşivi / 2016 / Cilt: 44 - Sayı: 5

Can ischemia-modified albumin help in differentiating myocardial perfusion scintigraphy results?

İskemi modifiye albümin miyokart perfüzyon sintigrafisi sonuçlarının ayırıcı tanısında faydalı olabilir mi?

Seyhan KARAÇAVUŞ
Ayşe Yeşim GÖÇMEN
Süleyman AKKAYA
Barış YAYLAK
Ali Rıza ERBAY
Hüseyin EDE
Pages
380–388
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Post- exercise IMA values of the normal and equivocal groups were similar (p=0.733), while that of the ischemia group was signifi- cantly higher than the values of either the normal (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Myocardial perfusion scintigraphy (MPS) is a di- agnostic tool commonly used to detect significant coronary lesion.
📊
Key Findings & Data:However equivocal, false negative or positive results can be yielded.
💡
Conclusion & Impact:Post- exercise IMA values of the normal and equivocal groups were similar (p=0.733), while that of the ischemia group was signifi- cantly higher than the values of either the normal (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Myocardial perfusion scintigraphy (MPS) is a di- agnostic tool commonly used to detect significant coronary lesion. However equivocal, false negative or positive results can be yielded. Controversial findings regarding the role of ischemia-modified albumin (IMA) in MPS evaluation persist. The aim of the present study was to examine the role of serum IMA in the assessment of MPS results. Methods: MPS using technetium (99mTc) sestamibi and trans- thoracic echocardiography was performed on 62 consecutive subjects prospectively enrolled. Exercise treadmill test (ETT) with modified Bruce protocol was used to induce coronary isch- emia. During MPS performance, blood samples for serum IMA were obtained at 3 times: at pre-exercise, at the peak of ETT, and 6 hours after ETT. Patients were classified into 3 groups according to MPS results (normal, equivocal, and ischemia). Results: Sixty-two patients (23 normal, 20 equivocal, 19 with ischemia) were included. Pre- and peak-exercise IMA values were similar among the groups (p=0.706 and 0.904). Post- exercise IMA values of the normal and equivocal groups were similar (p=0.733), while that of the ischemia group was signifi- cantly higher than the values of either the normal (p

Özet

Miyokart perfüzyon sintigrafisi (MPS) önemli koroner lezyonları tespit etmek için sıklıkla kullanılan tanı aracıdır. Ancak kuşkulu, yanlış negatif ve pozitif sonuçlar verebilir. Miyokart perfüzyon sintigrafisi sonuçlarının değerlendirilmesinde iskemi modifiye albüminin (İMA) rolü ile ilgili çalışmalar çelişkili sonuçlara sahiptir. Bu yazıda, MPS sonuçlarının değerlendirilmesinde serum İMA'nın rolünü incelemeyi amaçladık. Yöntemler: Miyokart perfüzyon sintigrafisi ile teknesyum (99mTc) sestamibi ve transtorasik ekokardiyografi uygulanan ardışık 62 hasta ileriye dönük olarak alındı. Koroner iskemisi oluşturmak için modifiye Bruce protokolü ile egzersiz tredmil testi (ETT) yapıldı. Miyokart perfüzyon sintigrafisi sırasında, serum İMA için egzersiz öncesi, egzersizin en yüksek düzeyinde ve ETT sonrası altıncı saatte kan örnekleri alındı. Hastalar MPS sonuçlarına göre üç grupta sınıflandırıldı (normal, kuşkulu ve iskemi). Bulgular: Altmış iki hasta (23 normal, 20 kuşkulu, 19 iskemili) dahil edildi. Gruplar arasında egzersiz öncesi ve en yüksek düzeyinde İMA değerleri benzerdi (p=0.706 ve 0.904). Normal ve kuşkulu grubun egzersiz sonrası İMA değerleri benzerken (p=0.733), iskemi grubununki hem normal gruptan (p

🔖

Cite This Article

KARAÇAVUŞ, S., GÖÇMEN, A. Y., AKKAYA, S., YAYLAK, B., ERBAY, A. R., EDE, H. (2022). Can ischemia-modified albumin help in differentiating myocardial perfusion scintigraphy results?. Türk Kardiyoloji Derneği Arşivi, Cilt: 44 - Sayı: 5, 380–388. https://ajindex.com/articles/632612

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (9)

  1. Pakkal M, Raj V, McCann GP. Non-invasive imaging in coronary artery disease including anatomical and functional evaluation of ischaemia and viability assessment. Br J Radiol 2011;84 Spec No 3:S280-95. Melikian N, De Bondt P, Tonino P, De Winter O, Wyffels E, Bartunek J, et al. Fractional flow reserve and myocardial per- fusion imaging in patients with angiographic multivessel cor- onary artery disease. JACC Cardiovasc Interv 2010;3:307-14.
  2. Berman DS, Kang X, Slomka PJ, Gerlach J, de Yang L, Hayes SW, et al. Underestimation of extent of ischemia by gated SPECT myocardial perfusion imaging in patients with left main coronary artery disease. J Nucl Cardiol 2007;14:521-8.
  3. Sbarouni E, Georgiadou P, Panagiotakos D, Kyrzopoulos S, Tsiapras D, Voudris V, et al. Ischemia modified albumin in relation to pharmacologic stress testing in coronary artery dis- ease. Clin Chim Acta 2008;396:58-61.
  4. Sbarouni E, Georgiadou P, Theodorakis GN, Kremastinos DT. Ischemia-modified albumin in relation to exercise stress test- ing. J Am Coll Cardiol 2006;48:2482-4.
  5. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantifi- cation: a report from the American Society of Echocardiogra- phy's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005;18:1440-63.
  6. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imag- ing Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 2002;105:539-42.
  7. Ozdemir S, Barutcu A, Gazi E, Tan YZ, Turkon H. The Re- lationship Between Some Complete Blood Count Parameters and Myocardial Perfusion: A Scintigraphic Approach. World J Nucl Med 2015;14:197-201.
  8. Koc ZP, Erkilic M, Basarıcı I, Deger N, Ozdem S, Saka O. Ischemia modified albumin levels cannot predict stress in- duced ischemia shown by myocardial perfusion scintigraphy. Rev Esp Med Nucl Imagen Mol 2012;31:202-6.
  9. Ede H, Karaçavuş S, Göçmen AY, Yaylak B, Akkaya S, Açıkgöz B, et al. Serum copeptin level can be a helpful bio değerlendirilmesinde faydalı olabilir. marker in evaluation of myocardial perfusion scintigraphy results. Cardiol J 2016;23:71-7. Sbarouni E,