Journals / Türk Kardiyoloji Derneği Arşivi / 2017 / Cilt: 45 - Sayı: 6

Serum oxidized low-density lipoprotein level as a marker of oxidative stress in patients undergoing hyperbaric oxygen therapy

Hiperbarik oksijen tedavisi gören hastalarda oksidatif stresin bir göstergesi olarak serum okside düşük yoğunluklu lipoprotein seviyesi

Pages
533–537
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, further large-scale studies investigating longer duration of HBOT treatment are required to understand the role of OS.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Oxidative stress (OS) is involved in the pathogenesis of atherosclerosis.
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Key Findings & Data:Hyperbaric oxygen therapy (HBOT), in which 100% oxygen is inhaled under hyperbaric pressure, may create OS.
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Conclusion & Impact:However, further large-scale studies investigating longer duration of HBOT treatment are required to understand the role of OS.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Oxidative stress (OS) is involved in the pathogenesis of atherosclerosis. Hyperbaric oxygen therapy (HBOT), in which 100% oxygen is inhaled under hyperbaric pressure, may create OS. Therefore, the aim of this research was to measure the serum oxidized low-density lipoprotein (oxLDL) level in patients undergoing HBOT.Methods: Twenty-nine patients who underwent HBOT to treat various diseases were enrolled in this study. The serum oxLDL level was measured at the beginning of the first and after the 10th therapy session.Results: There was no significant difference between the oxLDL level of patients before and after HBOT (4.96±0.1 vs. 4.94±0.1 U/mL; p=0.36).Conclusion: HBOT seems to be safe in terms of oxLDL production up to 10 sessions. However, further large-scale studies investigating longer duration of HBOT treatment are required to understand the role of OS.

Özet

Amaç: Aterosklerozun patogenezinde oksidatif stres yer almaktadır. Hiperbarik oksijen tedavisinde yüksek basınç altında %100 oksijen verilmesinden dolayı oksidatif stres için bir yatkınlık oluşabilir. Bu nedenle çalışmamızda hiperbarik oksijen tedavisine giren hastalarda oksidatif stresin bir göstergesi olan okside düşük yoğunluklu lipoprotein (oxLDL) seviyelerini ölçtük.Yöntemler: Çalışmaya, çeşitli hastalıklar sebebiyle hiperbarik oksijen tedavisine giren 29 hasta alındı. İlk seasın başlangıcında ve 10. seansın sonunda kan örnekleri alınarak oxLDL seviyeleri ölçüldü.Bulgular: Hiperbarik oksijen tedavisi uygulanan hastalarda oxLDL seviylerinde anlamlı bir değişiklik gözlenmemiştir (4.96±0.1 ve 4.94±0.16 U/ml, p=0.36).Sonuç: Onuncu seansa kadar olan hiperbarik oksijen tedavisi oxLDL oluşumu açısından güvenli gözükmektedir. Oksidatif stresin aydınlatılması için daha uzun süreli tedavilerin incelendiği büyük çaplı çalışmalara ihtiyaç vardır.

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Cite This Article

ÇETİNKAL, G., KESKİN, K., KİLCİ, H., TÜRK, F. K., BİNGÖL, G., AKSAN, G., YILDIZ, S. S. (2022). Serum oxidized low-density lipoprotein level as a marker of oxidative stress in patients undergoing hyperbaric oxygen therapy. Türk Kardiyoloji Derneği Arşivi, Cilt: 45 - Sayı: 6, 533–537. https://ajindex.com/articles/632554

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