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Journals / Türk Kardiyoloji Derneği Arşivi / 2018 / Cilt: 46 - Sayı: 3

Effect of statins on sirtuin 1 and endothelial nitric oxide synthase expression in young patients with a history of premature myocardial infarction

Erken miyokart enfarktüsü öyküsü olan genç hastalarda statinlerin sirtuin 1 ve endotel nitrik oksit sentaz ekspresyonu üzerine etkisi

Ülkan Kılıç
Aylin Hatice Yamaç
Pages
205–215
Publication Date
2022-11-05
DOI
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The levels of SIRT1 and eNOSprotein; oxidative stress markers, like total antioxidant status(TAS), total oxidant status (TOS), and the oxidative stress index(OSI); as well as the distribution of the SNPs rs7069102and rs2273773 were measured and analyzed.Results: A significant increase in the SIRT1 level (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The present study was an investigation of the effectof statins on the expression of circulating sirtuin 1 (SIRT1)and endothelial nitric oxide synthase (eNOS) proteins, and onthe distribution of single nucleotide polymorphisms (SNPs) ofthe SIRT1 gene in patients with a history of premature myocardialinfarction (PMI).Methods: A total of 108 patients who had suffered from a prematureST-elevation myocardial infarction (STEMI) under theage of 45 years were enrolled in this study.
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Key Findings & Data:While 79 patientshad been taking statins since the index event, 29 patients haddiscontinued statin treatment after hospital discharge due tononcompliance or insufficient information about the importanceof continuous statin therapy in post-MI patients.
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Conclusion & Impact:The levels of SIRT1 and eNOSprotein; oxidative stress markers, like total antioxidant status(TAS), total oxidant status (TOS), and the oxidative stress index(OSI); as well as the distribution of the SNPs rs7069102and rs2273773 were measured and analyzed.Results: A significant increase in the SIRT1 level (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The present study was an investigation of the effectof statins on the expression of circulating sirtuin 1 (SIRT1)and endothelial nitric oxide synthase (eNOS) proteins, and onthe distribution of single nucleotide polymorphisms (SNPs) ofthe SIRT1 gene in patients with a history of premature myocardialinfarction (PMI).Methods: A total of 108 patients who had suffered from a prematureST-elevation myocardial infarction (STEMI) under theage of 45 years were enrolled in this study. While 79 patientshad been taking statins since the index event, 29 patients haddiscontinued statin treatment after hospital discharge due tononcompliance or insufficient information about the importanceof continuous statin therapy in post-MI patients. Thecontrol group consisted of 91 healthy patients without a previouscardiovascular event. The levels of SIRT1 and eNOSprotein; oxidative stress markers, like total antioxidant status(TAS), total oxidant status (TOS), and the oxidative stress index(OSI); as well as the distribution of the SNPs rs7069102and rs2273773 were measured and analyzed.Results: A significant increase in the SIRT1 level (p

Özet

Amaç: Bu çalışma ile, statinlerin, erken miyokart enfarktüsü (EME) geçiren hastalarda dolaşımdaki SIRT1 ve endotel nitrik oksit sentaz (eNOS) proteinlerinin ekspresyonu üzerindeki ve SIRT1 geninin tekli nükleotit polimorfizmlerinin (SNP) dağılımı üzerindeki etkisi araştırılmıştır. Yöntemler: Bu çalışmaya, 45 yaşın altında ST yükselmeli miyokart enfarktüsü (STYEME) geçiren 108 hasta dahil edildi. İndeks olaydan sonra 79 hasta statin kullanırken, 29 hasta taburculuk sonrası uyumsuzluk ya da yetersiz bilgilendirme sonucu statin tedavisini bırakmıştır. Kontrol grubu, daha önce herhangi bir kardiyovasküler olayı bulunmayan 91 sağlıklı hasta tarafından oluşturuldu. Kan örnekleri en erken ME’den 3 ay sonra alındı. Oluşturulan 3 çalışma grubunda SIRT1 ve eNOS proteinlerinin miktarı, toplam antioksidan statüsü (TAS), toplam oksidan statüsü (TOS) ve oksidatif stres indeksi (OSI) gibi oksidatif stres belirteçlerinin yanı sıra SNP rs7069102 ve rs2273773’ün dağılımı incelendi. Bulgular: Her iki SNP için statin tedavisi alan hastalarda, tüm genotiplerde ve allellerde, kontrol grubu ile karşılaştırıldığında, SIRT1 düzeylerinde anlamlı bir artış (p

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Cite This Article

Kılıç, Ü., Yamaç, A. H. (2022). Effect of statins on sirtuin 1 and endothelial nitric oxide synthase expression in young patients with a history of premature myocardial infarction. Türk Kardiyoloji Derneği Arşivi, Cilt: 46 - Sayı: 3, 205–215. https://ajindex.com/articles/632480

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