AI Summary & Key Takeaways
AI InsightResults: SR-BI rs4238001 common-CC genotype was found to be more frequent in patients with MI+ than in control subjects (MI−; odds ratio 4.046, p
📌 3 Key Takeaways
Abstract
Objective: The scavenger receptor class B type 1 ( SR-BI, SCARB1), which is a high-density lipoprotein (HDL) recep- tor that mediates selective cholesteryl ester uptake, plays an important role in reverse cholesterol transport. This study investigated the distribution of polymorphic variants of the SR-BI gene in patients with coronary heart disease (CHD) with a history of early myocardial infarction (MI) at an early age and their effects on their serum lipid levels. Methods: SR-BI rs5888(T>C), rs4238001(C>T), and rs10846744(G>C) were analyzed in 100 male patients with CHD with a history of MI (MI+) who were younger than 50 years and 89 male control subjects without MI history (MI−) using real-time polymerase chain reaction (PCR) and mu- tant-allele–specific PCR techniques. Results: SR-BI rs4238001 common-CC genotype was found to be more frequent in patients with MI+ than in control subjects (MI−; odds ratio 4.046, p
Özet
Amaç: Kolesterol esterin selektif alımına aracılık eden bir yüksek yoğunluklu lipoprotein (HDL) reseptörü olan Çöp- çü reseptör sınıfı-B tip-1 (SR-BI, SCARB1), ters kolesterol taşınmasında önemli bir rol oynar. Bu çalışmada SR-BI ge- ninin polimorfik varyantlarının erken yaşta miyokart enfark- tüsü (MI) hikayesi olan koroner kalp hastalarındaki (KKH) dağılımı ve bunların serum lipidlerine etkisi incelenmiştir. Yöntemler: SR-BI rs5888(T>C), rs4238001(C>T) ve rs10846744(G>C), 50 yaşından önce MI öyküsü olan (MI (+)) 100 erkek KKH hastasında ve MI öyküsü olmayan (MI (–)) 89 erkek kontrolde real time-PCR ve mutant allel spesi- fik PCR teknikleri ile analiz edildi. Bulgular: MI(+) Hasta grubunda SR-BI rs4238001 ata- sal-CC genotipi frekansı MI(–) kontrol grubundan istatistik- sel olarak anlamlı yüksek bulunmuştur (OR:4.046, p