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Journals / Türk Kardiyoloji Derneği Arşivi / 2018 / Cilt: 46 - Sayı: 3

Lipid profile and atherogenic indices and their association with platelet indices in familial Mediterranean fever

Ailevi Akdeniz ateşi’nde lipit profili ve aterojenik indeks düzeyleri ve bunların trombosit indeksleri ile ilişkisi

Gökhan Çakırca
Muhammet Murat Çelik
Pages
184–190
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

In male FMF patients,whereas AIP, AC, and CRI I and II values were significantlyhigher than in female FMF patients, the platelet count,ESR, and HDL cholesterol levels were significantly lower (allp

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Objective & Hypothesis:Objective: The aim of this study was to investigate lipid profilesand atherogenic indices and their association with plateletindices in Familial Mediterranean Fever (FMF) patients.Methods: A total of 63 FMF patients and 51 healthy individualswere included in this retrospective study.
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Key Findings & Data:Inflammatory markervalues (erythrocyte sedimentation rate [ESR], C-reactive protein[CRP] and fibrinogen), platelet indices (mean plateletvolume, plateletcrit value, platelet large cell ratio, and plateletdistribution width), lipid profiles (levels of total cholesterol,triglycerides, high-density lipoprotein [HDL] cholesterol, andlow-density lipoprotein cholesterol) were recorded.
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Conclusion & Impact:In male FMF patients,whereas AIP, AC, and CRI I and II values were significantlyhigher than in female FMF patients, the platelet count,ESR, and HDL cholesterol levels were significantly lower (allp
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to investigate lipid profilesand atherogenic indices and their association with plateletindices in Familial Mediterranean Fever (FMF) patients.Methods: A total of 63 FMF patients and 51 healthy individualswere included in this retrospective study. Inflammatory markervalues (erythrocyte sedimentation rate [ESR], C-reactive protein[CRP] and fibrinogen), platelet indices (mean plateletvolume, plateletcrit value, platelet large cell ratio, and plateletdistribution width), lipid profiles (levels of total cholesterol,triglycerides, high-density lipoprotein [HDL] cholesterol, andlow-density lipoprotein cholesterol) were recorded. Atherogenicindices (atherogenic index of plasma [AIP], atherogeniccoefficient [AC], Castelli’s risk indices I and II [CRI I and II])were calculated using lipid parameters.Results: In FMF patients, while AIP, AC, and CRI I and II valueswere significantly higher than in the healthy control group,the HDL cholesterol level was significantly lower (all p0.05). In male FMF patients,whereas AIP, AC, and CRI I and II values were significantlyhigher than in female FMF patients, the platelet count,ESR, and HDL cholesterol levels were significantly lower (allp

Özet

Amaç: Bu çalışmada, Ailevi Akdeniz Ateşi (AAA) hastalarında lipit profili ve aterojenik indeks düzeylerini ve bunların trombosit indeksleri ile olan ilişkisini araştırmayı amaçladık. Yöntemler: Bu geriye dönük çalışmaya AAA’lı 63 hasta ve sağlıklı 51 birey dahil edildi. Enflamatuvar belirteçlerin (eritrosit sedimantasyon hızı [ESR], C-reaktif protein [CRP] ve fibrinojen), trombosit indekslerinin (ortalama trombosit hacmi, trombosit krit, büyük trombosit oranı ve trombosit dağılım genişliği) ve lipit parametrelerinin (toplam kolesterol, trigliserit, düşük yoğunluklu lipoprotein kolesterol ve yüksek yoğunluklu lipoprotein kolesterol) düzeyleri kaydedildi. Ayrıca, aterojenik indeksler (plazma aterojenik indeksi [AIP], aterojenik katsayı [AK], Castelli risk indeksleri I ve II [CRI-I ve II]) lipit parametreleri kullanılarak hesaplandı. Bulgular: AAA’lı hastalarda AIP, AK, CRI-I ve II düzeyleri sağlıklı kontrol grubuna göre anlamlı derecede yüksek iken, yüksek yoğunluklu lipoprotein kolesterol düzeyi anlamlı derecede düşüktü (p0.05). AAA’lı erkek hastalarda AIP, AK, CRI-I ve II düzeyleri kadın hastalara göre anlamlı derecede yüksek iken, trombosit, ESR ve yüksek yoğunluklu lipoprotein kolesterol düzeyleri anlamlı derecede düşüktü (p

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Cite This Article

Çakırca, G., Çelik, M. M. (2022). Lipid profile and atherogenic indices and their association with platelet indices in familial Mediterranean fever. Türk Kardiyoloji Derneği Arşivi, Cilt: 46 - Sayı: 3, 184–190. https://ajindex.com/articles/632199

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